Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts the interaction with FKBP12 and FKBP52

Regulatory Peptides

Volumn 97, Issue 2-3, 2001, Pages 147-152

  Neye, H ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

FAP48; FKBP; Yeast two hybrid system

Indexed keywords

CALCIUM CHANNEL; CYCLOPHILIN; CYCLOSPORIN A; FK 506 BINDING PROTEIN; IMMUNOPHILIN; IMMUNOSUPPRESSIVE AGENT; MUTANT PROTEIN; PROLINE; RAPAMYCIN; REGULATOR PROTEIN; STEROID RECEPTOR; TACROLIMUS;

ARTICLE; BINDING SITE; GENE MUTATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BASE SEQUENCE; DNA PRIMERS; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; TACROLIMUS BINDING PROTEIN 1A; TACROLIMUS BINDING PROTEINS;

EID: 0035794039     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(00)00206-8     Document Type: Article

References (17)

1. The mechanism of action of cyclosporin A and FK506
2. Neural actions of immunophilin ligands
3. FK506 and the role of the immunophilin FKBP-52 in nerve regeneration
4. Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13
5. A rapamycin selective 25 kDa
6. The calcium release channel of sarcoplasmic reticulum is modulated by FK-506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum
7. FKBP12 binds the inositol 1,4,5-triphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain
8. The non-DNA-binding heterooligomeric form of mammalian steroid hormone receptors contains a hsp90-bound 59-kilodalton protein
9. A 59-kilodalton protein associated with progestin, estrogen, androgen and glucocorticoid receptors
10. Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12
11. FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin
12. Substrate specificity for the human rotamase FKBP: A view of FK506 and rapamycin as leucine-(twisted amide)-proline mimics
13. CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins
14. Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12
15. FK506 binding protein associated with the calcium release channel (ryanodine receptor)
16. The 13-kDa FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1
17. An Arabidopsis immunophilin, AtFKBP12, binds to AtFIP37 (FKBP interacting protein) in an interaction that is disrupted by FK506