Comparison of two murine models of familial hypertrophic cardiomyopathy

Circulation Research

Volumn 88, Issue 4, 2001, Pages 383-389

  McConnell, Bradley K ^b   Fatkin, Diane ^a   Semsarian, Christopher ^b   Jones, Karen A ^b   Georgakopoulos, Dimitrios ^c   Maguire, Colin T ^d,e   Healey, Michael J ^b   Mudd, James O ^b   Moskowitz, Ivan P G ^a   Conner, David A ^b   Giewat, Michael ^b   Wakimoto, Hiroko ^d,e   Berul, Charles I ^d,e   Schoen, Frederick J ^a   Kass, David A ^c   Seidman, Christine E ^a   Seidman, Jonathan G ^b,e  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c DEPARTMENT OF PATHOLOGY   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cardiac myosin binding protein C; Cardiomyopathy; Genetics; Hypertrophy; Myosin

Indexed keywords

GENE PRODUCT; MYOSIN BINDING PROTEIN C; MYOSIN HEAVY CHAIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; ELECTROPHYSIOLOGY; EXPERIMENTAL MODEL; FAMILIAL DISEASE; GENE EXPRESSION; GENETIC RECOMBINATION; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE TACHYCARDIA; HISTOPATHOLOGY; HYPERTROPHIC CARDIOMYOPATHY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MISSENSE MUTATION; NONHUMAN; PATHOGENESIS; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; STEM CELL;

EID: 0035793919     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.88.4.383     Document Type: Article

References (28)

1. Molecular and cellular biology of cardiac hypertrophy and failure
2. Hypertrophic cardiomyopathy
3. Patterns and significance of distribution of left ventricular hypertrophy in hypertrophic cardiomyopathy: A wide angle, two dimensional echocardiographic study of 125 patients
4. Distribution of left ventricular hypertrophy in hypertrophic cardiomyopathy: A two-dimensional echocardiographic study
5. Molecular genetic studies of familial hypertrophic cardiomyopathy
6. Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy
7. Mutations in the gene for cardiac myosin-binding protein C and late-onset familial hypertrophic cardiomyopathy
8. Clinical features and prognostic implications of familial hypertrophic cardiomyopathy related to the cardiac myosin-binding protein C gene
9. Mice expressing mutant myosin heavy chains are a model for familial hypertrophic cardiomyopathy
10. A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy
11. A mouse model of familial hypertrophic cardiomyopathy
12. The pathogenesis of Familial hypertrophic cardiomyopathy: Early and evolving effects from an α-cardiac myosin heavy chain missense mutation
13. 403/+ mouse model of familial hypertrophic cardiomyopathy
14. Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice
15. Molecular biology and genetics of cardiac disease associated with sudden death: Electrophysiologic studies in mouse models of inherited diseases
16. Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the α cardiac myosin heavy chain gene
17. Continuous measurement of left ventricular volume in animals and humans by conductance catheter
18. In vivo cardiac electrophysiology studies in the mouse
19. Electrophysiological abnormalities and arrhythmias in αMHC mutant familial hypertrophic cardiomyopathy mice
20. Troponin 1 phosphorylation and myofilament calcium sensitivity during decompensated cardiac hypertrophy
21. Heterologous expression of a cardiomyopathic myosin that is defective in its actin interaction
22. The in vitro mobility activity of β-cardiac myosin depends on the nature of the β-myosin heavy chain gene mutation in hypertrophic cardiomyopathy
23. Abnormal contractile properties of muscle fibers expressing β-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy
24. 403/+ mouse model of familial hypertrophic cardiomyopathy
25. Altered cardiac excitation-contraction coupling in mutant mice with familial hypertrophic cardiomyopathy
26. Value of programmed electrical stimulation using a standardized ventricular stimulation protocol in hypertrophic cardiomyopathy
27. Programmed electrical stimulation in hypertrophic cardiomyopathy: Results in patients with and without cardiac arrest or syncope
28. Mutations in the cardiac myosin binding protein-C gene on chromosome 11 cause familial hypertrophic cardiomyopathy