Immobilized amyloid precursor protein constructs: A tool for the in vitro screening of glial cell reactivity

European Journal of Neuroscience

Volumn 14, Issue 6, 2001, Pages 946-956

  Von Bernhardi, Rommy ^a   Ramírez, Gigliola ^a   Matile, Hugues ^b   Döbeli, Heinz ^b  

^a UNIVERSIDAD DE LOS ANDES   (Chile)

^b Pharma Research   (Switzerland)

Author keywords

Alzheimer's disease; Amyloid; Cell proliferation; Microglia; Rat; Senile plaques

Indexed keywords

AMYLOID PRECURSOR PROTEIN; AMYLOID PROTEIN; EPITOPE; PROTEIN ANTIBODY;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; ASTROCYTE; CARBOXY TERMINAL SEQUENCE; CELL ACTIVITY; CELL PROLIFERATION; CONTROLLED STUDY; GENE CONSTRUCT; IMMUNOFLUORESCENCE; MASS SPECTROMETRY; MICROGLIA; MOUSE; NEWBORN; NONHUMAN; PATHOGENESIS; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN IMMOBILIZATION; RAT; SCREENING TEST; SENILE PLAQUE;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; CELLS, CULTURED; CLONING, MOLECULAR; ENDOCYTOSIS; ENDOPEPTIDASES; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INDICATORS AND REAGENTS; MASS SPECTROMETRY; MICROSPHERES; NEUROGLIA; NITRITES;

EID: 0035783754     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0953-816X.2001.01715.x     Document Type: Article

References (34)

1. Afagh, A., Cummings, B.J., Cribbs, D.H., Cotman, C.W. & Tenner, A.J. (1996) Localization and cell association of C1q in Alzheimer's disease brain. Exp. Neurol., 138, 22-32.
2. Brazil, M.I., Chung, H. & Maxfield, F.R. (2000) Effects of incorporation of immunoglobulin G and complement component C1q on uptake and degradation of Alzheimer's disease amyloid fibrils by microglia. J. Biol. Chem., 275, 16941-16947.
3. Dickson, D.W. (1997) The pathogenesis of senile plaques. J. Neuropathol. Exp. Neurol., 56, 321-339.
4. Dickson, D.W., Lee, S.C., Mattiace, L.A., Yen, S.H. & Brosnan, C. (1993) Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia, 7, 75-83.
5. El Khoury, J., Hickman, S.E., Thomas, C.A., Cao, L., Silverstein, S.C. & Loike, J.D. (1996) Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils. Nature, 382, 716-719.
6. Fountoulakis, M. & Langen, H. (1997) Identification of proteins by matrix-assisted laser desorption ionization-mass spectrometry following in-gel digestion in low-salt, nonvolatile buffer and simplified peptide recovery. Anal. Biochem., 250, 153-156.
7. Gilg, A.G., Singh, A.K. & Singh, I. (2000) Inducible nitric oxide synthase in the central nervous system of patients with X-adrenoleukodystrophy. J. Neuropathol. Exp. Neurol., 59, 1063-1069.
8. Giulian, D. & Baker, T.J. (1986) Characterization of amoeboid microglia isolated from developing mammalian brain. J. Neurosci., 6, 2163-2178.
9. Giulian, D., Haverkamp, L.J., Li, J., Karshin, W.L., Yu, J., Tom, D., Li, X. & Kirkpatrick, J.B. (1995b) Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain. Neurochem. Int., 27, 119-137.
10. Giulian, D., Li, J., Bartel, S., Broker, J., Li, X. & Kirkpatrick, J.B. (1995a) Cell surface morphology identifies microglia as a distinct class of mononuclear phagocyte. J. Neurosci., 15, 7712-7726.
11. Grüninger-Leitch, F., Berndt, P., Langen, H., Nelboeck, P. & Döbeli, H. (2000) Identification of ̈-secretase like activity using a mass spectrometry based assay system. Nature Biotechnol., 18, 66-70.
12. Hochuli, E., Döbeli, H. & Schacher, A. (1987) New metal chelate adsorbent selective for proteins and peptides containing neighbouring histidine residues. J. Chromatogr., 411, 177-184.
13. Ida, N., Hartmann, T., Pantel, J., Schroder, J., Zerfass, R., Forstl, H., Sandbrink, R., Masters, C.L. & Beyreuther, K. (1996) Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. J. Biol. Chem., 271, 22908-22914.
14. Itagaki, S., McGeer, P.L., Akiyama, H., Zhu, S. & Selkoe, D. (1989) Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J. Neuroimmunol., 24, 173-182.
15. 1-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition. Nature Med., 6, 143-150.
16. Lee, S.C., Liu, W., Brosman, C.F. & Dickson, D.W. (1994) GM-CSF promotes proliferation of human fetal and adult microglia in primary cultures. Glia, 12, 309-318.
17. Martin, L.J., Pardo, C.A., Cork, L.C. & Price, D.L. (1994) Synaptic pathology and glial responses to neuronal injury precede the formation of senile plaques and amyloid deposits in the aging cerebral cortex. Am. J. Pathol., 145, 1358-1381.
18. McLaurin, J., Almazan, G., Williams, K. & Antel, J.P. (1995) Immortalization and characterization of rat microglial cells. Neuropathol. App. Neurobiol., 21, 302-311.
19. Paresce, D.M., Chung, H. & Maxfield, F.R. (1997) Slow degradation of aggregates of the Alzheimer's disease amyloid β-protein by microglial cells. J. Biol. Chem., 272, 29390-29397.
20. Paresce, D.M., Ghosh, R.N. & Maxfield, F.R. (1996) Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via scavenger receptor. Neuron, 17, 553-565.
21. Perlmutter, L.S., Scott, S.A., Baron, E. & Chui, H.C. (1992) MHC class II-positive microglia in human brain: Association with Alzheimer's lesions. J. Neurosci. Res., 33, 549-558.
22. Pfeiffer, S., Gorren, A.C.F., Schmidt, K., Werner, E.R., Hanser, B., Bohle, D.S. & Mayer, B. (1997) Metabolic fate of peroxynitrite in aqueous solution. J. Biol. Chem., 272, 3465-3470.
23. Rozemuller, J.M., Eikelenboom, P., Pals, S.T. & Stam, F.C. (1989) Microglial cells around amyloid plaques in Alzheimer's disease express leukocyte adhesion molecules of the LFA-1 family. Neurosci. Lett., 101, 288-292.
24. Sasaki, A., Yamaguchi, H., Ogawa, A., Sugihara, S. & Nakasato, Y. (1997) Microglial activation in early stages of amyloid beta protein deposition. Acta Neuropathol. (Berl.), 94, 316-322.
25. Schubert, P., Morino, T., Miyazaki, H., Ogata, T., Nakamura, Y., Marchini, C. & Ferroni, S. (2000) Cascading glia reactions: A common pathomechanism and its differentiated control by cyclic nucleotide signaling. Ann. NY Acad. Sci., 903, 24-33.
26. Selkoe, D.J. (1991) The molecular pathology of Alzheimer's disease. Neuron, 6, 487-498.
27. Shaffer, L.M., Dority, M.D., Gupta-Bansal, R., Frederickson, R.C. & Youkin, S.G. (1995) Amyloid beta protein (A beta) removal by neuroglial cells in culture. Neurobiol. Aging, 16, 737-745.
28. Sheng, J.G., Mrak, R.E. & Griffin, W.S. (1995) Microglial interleukin-1 alpha expression in brain regions in Alzheimer's disease: Correlation with neuritic plaque distribution. Neuropathol. Appl. Neurobiol., 21, 290-301.
29. Shigematsu, K., McGeer, P.L., Walker, D.G., Ishii, T. & McGeer, E.G. (1992) Reactive microglia/macrophages phagocytose amyloid precursor protein produced by neurones following neural damage. J. Neurosci. Res., 31, 443-453.
30. Stalder, M., Phinney, A., Probst, A., Sommer, B., Staufenbiel, M. & Jucker, M. (1999) Association of microglia with amyloid plaques in brains of APP23 transgenic mice. Am. J. Pathol., 154, 1673-1684.
31. Streit, W.J. (1990) An improved staining method for rat microglial cells using the lectin from Griffonia simplicifolia (GSA I-B4). J. Histochem. Cytochem., 38, 1683-1686.
32. Wegiel, J. & Wisniewski, H.M. (1990) The complex of microglial cells and amyloid star in three-dimensional reconstruction. Acta Neuropathol. (Berl.), 81, 116-124.
33. Yamaguchi, H., Sugihara, S., Ogawa, A., Saido, T.C. & Ihara, Y. (1998) Diffuse plaques associated with astroglial amyloid beta protein, possibly showing a disappearing stage of senile plaques. Acta Neuropathol. (Berl.), 95, 217-222.
34. Zhao, M.L., Liu, J.S., He, D., Dickson, D.W. & Lee, S.C. (1998) Inducible nitric oxide synthase expression is selectively induced in astrocytes isolated from adult human brain. Brain. Res., 813, 402-405.