Strain differences in the behavioural outcome of neonatal ventral hippocampal lesions are determined by the postnatal environment and not genetic factors

European Journal of Neuroscience

Volumn 14, Issue 6, 2001, Pages 1030-1034

  Wood, Graham K ^a   Marcotte, Eric R ^a   Quirion, Remi ^a   Srivastava, Lalit K ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Animal model; Cross fostering and maternal behaviour; Environment; Genetic; Locomotion; Neurodevelopment; Schizophrenia

Indexed keywords

AMPHETAMINE; IBOTENIC ACID;

ANALYSIS OF VARIANCE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; FEMALE; HEREDITY; HIPPOCAMPUS; LOCOMOTION; MATERNAL BEHAVIOR; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT STRAIN; STRAIN DIFFERENCE;

AMPHETAMINE; ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; CENTRAL NERVOUS SYSTEM STIMULANTS; ENVIRONMENT; FEMALE; HIPPOCAMPUS; MATERNAL BEHAVIOR; MOTOR ACTIVITY; PREGNANCY; RATS; RATS, INBRED F344; RATS, INBRED LEW; SPECIES SPECIFICITY;

EID: 0035783481     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0953-816X.2001.01716.x     Document Type: Article

References (22)

1. Cabib, S., Orsini, C., Le Moal, M. & Piazza, P.V. (2000) Abolition and reversal of strain differences in behavioral responses to drugs of abuse after a brief experience. Science, 289, 463-465.
2. Cannon, T.D., Kaprio, J., Lonnqvist, J., Huttunen, M. & Koskenvuo, M. (1998) The genetic epidemiology of schizophrenia in a Finnish twin cohort. A population-based modeling study. Arch. Gen. Psychiatry, 55, 67-74.
3. Cardno, A.G. & Gottesman, I.I. (2000) Twin studies of schizophrenia: From bow-and-arrow concordances to Star Wars Mx and functional genomics. Am. J. Med. Genet., 97, 12-17.
4. Ellenbroek, B.A. & Cools, A.R. (2000) The long-term effects of maternal deprivation depend on the genetic background. Neuropsychopharmacology, 23, 99-106.
5. Ellenbroek, B.A., Sluyter, F. & Cools, A.R. (2000) The role of genetic and early environmental factors in determining apomorphine susceptibility. Psychopharmacology (Berl.), 148, 124-131.
6. Flores, G., Barbeau, D., Quirion, R. & Srivastava, L.K. (1996) Decreased binding of dopamine D3 receptors in limbic subregions after neonatal bilateral lesion of rat hippocampus. J. Neurosci., 16, 2020-2026.
7. Hall, F.S., Wilkinson, L.S., Humby, T. & Robbins, T.W. (1999) Maternal deprivation of neonatal rats produces enduring changes in dopamine function. Synapse, 32, 37-43.
8. Harvey, A.T., Moore, H., Lucot, J.B. & Hennessy, M.B. (1994) Monoamine activity in anterior hypothalamus of guinea pig pups separated from their mothers. Behav. Neurosci., 108, 171-176.
9. Jablensky, A. (1995) Schizophrenia: The epidemiological horizon. In: Hirsch, S.R. & Weinberger, D.R. (eds), Schizophrenia. Blackwell Science, Oxford, pp. 206-252.
10. Kolb, B. & Whishaw, I.Q. (1985) Earlier is not always better: Behavioral dysfunction and abnormal cerebral morphogenesis following neonatal cortical lesions in the rat. Behav. Brain Res., 17, 25-43.
11. Lipska, B.K., Jaskiw, G.E. & Weinberger, D.R. (1993) Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: A potential animal model of schizophrenia. Neuropsychopharmacology, 9, 67-75.
12. Lipska, B.K., Kolb, B., Halim, N.D. & Weinberger, D.R. (2001) Synaptic abnormalities in prefrontal cortex and nucleus accumbens of adult rats with neonatal hippocampal damage. Schizophr. Res., 49, 47.
13. Lipska, B.K. & Weinberger, D.R. (1995) Genetic variation in vulnerability to the behavioral effects of neonatal hippocampal damage in rats. Proc. Natl. Acad. Sci. USA, 92, 8906-8910.
14. Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P.M. & Meaney, M.J. (1997) Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science, 277, 1659-1662.
15. Matthews, K., Robbins, T.W., Everitt, B.J. & Caine, S.B. (1999) Repeated neonatal maternal separation alters intravenous cocaine self-administration in adult rats. Psychopharmacology (Berl.), 141, 123-134.
16. Meaney, M.J., Aitken, D.H., Bodnoff, S.R., Iny, L.J. & Sapolsky, R.M. (1985) The effects of postnatal handling on the development of the glucocorticoid receptor systems and stress recovery in the rat. Prog. Neuropsychopharmacol. Biol. Psychiatry, 9, 731-734.
17. van Praag, H., Alberch, J., Perez-Navarro, E., Wu, H., Qu, P.M., Black, I.B. & Dreyfus, C.F. (1996) Unilateral neonatal hippocampal lesion alters septal innervation and trophism of the entorhinal cortex. Exp. Neurol., 141, 130-140.
18. Rots, N.Y., de Jong, J., Workel, J.O., Levine, S., Cools, A.R. & De Kloet, E.R. (1996) Neonatal maternally deprived rats have as adults elevated basal pituitary-adrenal activity and enhanced susceptibility to apomorphine. J. Neuroendocrinol., 8, 501-506.
19. Schroeder, H., Grecksch, G., Becker, A., Bogerts, B. & Hoellt, V. (1999) Alterations of the dopaminergic and glutamatergic neurotransmission in adult rats with postnatal ibotenic acid hippocampal lesion. Psychopharmacology (Berl.), 145, 61-66.
20. Silva, A.B., Zaldivar, G., Stewart, J., Quirion, R., Srivastava, L.K. & Flores, G. (2001) Decreased dendritic spine density on prefrontal cortical pyramidal neurons in adult rats following neonatal excitotoxic lesions of the ventral hippocampus. Soc. Neurosci. Abstr., 27, 26.
21. Villescas, R., Bell, R.W., Wright, L. & Kufner, M. (1977) Effect of handling on maternal behavior following return of pups to the nest. Dev. Psychobiol., 10, 323-329.
22. Wan, R.Q., Hartman, H. & Corbett, R. (1998) Alteration of dopamine metabolites in CSF and behavioral impairments induced by neonatal hippocampal lesions. Physiol. Behav., 65, 429-436.