Gap junctional communication among motor and other neurons shapes patterns of neural activity and synaptic connectivity during development

Cell Communication and Adhesion

Volumn 8, Issue 4-6, 2001, Pages 329-333

  Personius, Kirk ^a,b   Chang, Qiang ^a,c   Bittman, Kevin ^a   Panzer, Jessica ^a   Balice Gordon, Rita ^a,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^d 215 Stemmler Hall ^*  (United States)

Author keywords

Connexin; Motor neuron; Neuromuscular junction; Spinal cord; Synaptic plasticity

Indexed keywords

CONNEXIN 40; DYE; GAP JUNCTION PROTEIN;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CELL COMMUNICATION; CELL FUNCTION; CONTROLLED STUDY; CORRELATION ANALYSIS; EMBRYO; EMBRYO DEVELOPMENT; FREQUENCY ANALYSIS; GAP JUNCTION; IN VIVO STUDY; INNERVATION; MOTONEURON; MOTOR ACTIVITY; MOUSE; MUSCLE CELL; NERVE CELL; NERVE CELL NETWORK; NERVE CONDUCTION; NEUROMUSCULAR SYNAPSE; NEWBORN; NONHUMAN; PERINATAL DEVELOPMENT; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN DEFICIENCY; TARGET CELL; WAKEFULNESS;

ANIMALIA;

EID: 0035754415     PISSN: 10615385     EISSN: None     Source Type: Journal    
DOI: 10.3109/15419060109080748     Document Type: Article

References (22)

1. Bailce-Gordon, R. J., and J. W. Lichtman. 1994. Long-term synapse loss induced by focal blockade of postsynaptic receptors. Nature 372:519-524.
2. Busetto, G., et al. 2000. Hebbian mechanisms revealed by electrical stimulation at developing rat neuromuscular junctions. J. Neurosci. 20:685-695.
3. Chang, Q., et al. 1999. Gap junctional coupling and patterns of connexin expression among neonatal rat lumbar spinal motor neurons. J. Neurosci. 19:10813-10828.
4. Chang, Q., et al. 2000. Nerve injury induces gap junctional coupling among axotomized adult motor neurons. J. Neurosci. 20:674-684.
5. Clarac, F., et al. 1998. Role of gravity in the development of posture and locomotion in the neonatal rat. Brain Res. Reviews 28:35-43.
6. Feller, M. 1999. Spontaneous correlated activity in developing neural circuits. Neuron 22:653-656.
7. Fulton, B. P., et al. 1980. Electrical synapses between motoneurons in the spinal cord of the newborn rat. Proc. R. Soc. Lond. 208:115-120.
8. Gan, W. B., et al. 2000. Multicolor DiOlistic labeling of the nervous system using lipophilic dye combinations. Neuron 27:219-25.
9. Hennig, R., and Lomo, T. 1985. Firing patterns of motor units in normal rats. Nature 314:164-166.
10. Jellinck, P. H., et al. 1993. Differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues. J. Steroid Biochem. Mol. Biol. 46:209-213.
11. Kudo, T., and Yamada, T. 1987. Morphological and physiological studies of development of the monosynaptic reflex pathway in the rat lumbar spinal cord. J. Physiol. 389:441-459.
12. Lichtman, J. W., and Colman, H. 2000. Synapse elimination and indelible memory. Neuron 25:269-278.
13. Milner, L. D., and Landmesser, L. T. 1999. Cholinergic and GABAergic inputs drive patterned spontaneous motoneuron activity before target contact. J. Neurosci. 19:3007-3022.
14. Nordstrom, M. A., et al. 1992. Estimating the strength of common input to human motoneurons from the cross-correlogram. J. Physiol. 453:547-574.
15. Personius, K. E., and Bailce-Gordon, R. J. 2000. Activity-dependent editing of neuromuscular synaptic connections. Brain Res. Bull. 53:513-522.
16. Personius, K. E., and Balice-Gordon, R. J. 2001. Loss of correlated motor neuron activity during synaptic competition at developing neuromuscular synapses. Neuron 31:395-408.
17. Rich, M. M., and Lichtman, J. W. 1989. In vivo visualization of pre-and postsynaptic changes during synapse elimination in reinnervated mouse muscle. J. Neurosci. 9:1781-1805.
18. Sears, T. A., and Stagg, D. 1976. Short-term synchronization of intercostal motoneurone activity. J. Physiol. 263:357-381.
19. Simon, A. M., et al. 1998. Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block. Curr. Biol. 8:295-298.
20. Thompson, W. 1983. Synapse elimination in neonatal rat muscle is sensitive to pattern of muscle use. Nature 302:614-616.
21. Tresch, M. C., and Kiehn, O. 2000. Motor coordination without action potentials in the mammalian spinal cord. Nat. Neurosci. 3:593-599.
22. Walton, K. D., and Navarette, R. 1991. Postnatal changes in motoneurone electrotonic coupling studied in the in vitro rat lumbar spinal cord. J. Physiol. 433:283-305.