Trap a gene and find out its function: Toward functional genomics in Drosophila

Journal of Neurogenetics

Volumn 15, Issue 3-4, 2001, Pages 147-168

  Lukacsovich, Tamas ^a   Yamamoto, Daisuke ^a  

^a WASEDA UNIVERSITY   (Japan)

Author keywords

Conditional expression; Double insertion; Gene trapping; Insertional mutagenesis; P element

Indexed keywords

CAENORHABDITIS; CORRELATION ANALYSIS; DROSOPHILA; DROSOPHILA MELANOGASTER; ESCHERICHIA COLI; EXPRESSED SEQUENCE TAG; FUTUROLOGY; GENE IDENTIFICATION; GENE ISOLATION; GENE MAPPING; GENE SEQUENCE; GENE TRAPPING; GENETIC VARIABILITY; MARKER GENE; MATHEMATICAL COMPUTING; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DETERMINATION; RELIABILITY; REVIEW; YEAST;

CAENORHABDITIS; CAENORHABDITIS DROSOPHILAE; DROSOPHILA; DROSOPHILA MELANOGASTER; ESCHERICHIA COLI; EUKARYOTA; INSERTION SEQUENCES; MELANOGASTER;

EID: 0035738851     PISSN: 01677063     EISSN: None     Source Type: Journal    
DOI: 10.3109/01677060109167373     Document Type: Review

References (57)

1. The genome sequence of Drosophila melanogaster
2. P-element-mediated enhancer detection: A versatile method to study development in Drosophila
3. Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector
4. Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular traffic
5. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
6. Novel features of Drosophila period transcription revealed by real-time luciferase reporting
7. Analysis of mammalian cell genetic regulation in situ by using retrovirus-derived "portable exons" carrying the Escherichia coli lacZ gene
8. Different TBP-associated factors are required for mediating the stimulation of transcription in vitro by the acidic transactivator GAL-VP16 and the two nonacidic activation functions of the estrogen receptor
9. Homeotic genes and the regulation and evolution of insect wing number
10. Molecular basis of transabdominal - A sexually dimorphic mutant of the bithorax complex of Drosophila
11. At least two genes reside within a large intron of the dunce gene of Drosophila
12. Multiple forms of dynamin are encoded by shibire, a Drosophila gene involved in endocytosis
13. Mariner transposition and transformation of the yellow fever mosquito, Aedes aegypti
14. Insertional mutagenesis of the Drosophila genome with single P elements
15. P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: Correlation of physical and cytogenetic maps in chromosomal region 86E-87F
16. Requirement for Drosophila cytoplasmic tropomyosin in oskar mRNA localization
17. The two-hybrid system: An assay for protein-protein interactions
18. Temperature-dependent gene silencing by an expressed inverted repeat in Drosophila
19. Enhancer-trap targeting at the Broad-Complex locus of Drosophila melanogaster
20. Hormone-inducible expression of secreted factors in zebrafish embryos
21. Probable mechanisms underlying interallelic complementation and temperature-sensitivity of mutations at the shibire locus of Drosophila melanogaster
22. Investigating the function of follicular subpopulations during Drosophila oogenesis through hormone-dependent enhancer-targeted cell ablation
23. 'Promoter trapping' in Caenorhabditis elegans
24. Gene silencing: Shrinking the black box of RNAi
25. Sexual orientation in Drosophila is altered by the satori mutation in the sex-determination gene fruitless that encodes a zinc finger protein with a BTB domain
26. Molecular structure of a somatically unstable transposable element in Drosophila
27. Stable transformation of the yellow fever mosquito, Aedes aegypti, with the Hermes element from the housefly
28. Heritable gene silencing in Drosophila using double-stranded RNA
29. Conditional modification of behavior in Drosophila by targeted expression of a temperature-sensitive shibire allele in defined neurons
30. Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein
31. RNA pseudoknots downstream of the frameshift sites of retroviruses
32. Functional genomics in Drosophila melanogaster by gene-trapping
33. Dual-tagging gene-trap of novel genes in Drosophila melanogaster
34. Gene targeting in embryonic stem cells: The new physiology and metabolism
35. Splicing signals in Drosophila: Intron size, information content, and consensus sequences
36. Detection in situ of genomic regulatory elements in Drosophila
37. Quantitative analysis of Drosophila period gene transcription in living animals
38. A stable genomic source of P element transposase in Drosophila melanogaster
39. A targeted gene knockout in Drosophila
40. Gene targeting by homologous recombination in Drosophila
41. A modular misexpression screen in Drosophila detecting tissue-specific phenotypes
42. Systematic gain-of-function genetics in Drosophila
43. Transgenic plants as tools to study the molecular organization of plant genes
44. Amplification of oncogenes in human cancer cells
45. Conversion of lacZ enhancer trap lines to GAL4 lines using targeted transposition in Drosophila melanogaster
46. Gene disruptions using P transposable elements: An integral component of the Drosophila genome project
47. The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes
48. Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila
49. RNAi in C. elegans: Soaking in the genome sequence
50. Pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor
51. Precise excision and transposition of piggy Bac in pink bollworm embryos
52. The gene search system. A method for efficient detection and rapid molecular identification of genes in Drosophila melanogaster
53. P-lacW insertional mutagenesis on the second chromosome of Drosophila melanogaster: Isolation of lethals with different overgrowth phenotypes
54. Targeted mRNA degradation by double-stranded RNA in vitro
55. Transposon-generated 'knock-out' and 'knock-in' gene-targeting constructs for use in mice
56. P-element-mediated enhancer detection: An efficient method for isolating and characterizing developmentally regulated genes in Drosophila
57. Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells