Atopy and mutations of IL-12 receptor β2 chain gene

Clinical and Experimental Allergy

Volumn 31, Issue 8, 2001, Pages 1189-1193

  Kondo, N ^a   Matsui, E ^a   Kaneko, H ^a   Fukao, T ^a   Teramoto, T ^a   Inoue, R ^a   Watanabe, M ^a   Aoki, M ^a   Kasahara, K ^a   Morimoto, N ^a  

^a GIFU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; LYMPHOKINE; PROTEIN P35; PROTEIN P40; STAT4 PROTEIN;

ALLERGY; AMINO ACID SEQUENCE; ATOPY; CELL DIFFERENTIATION; CYTOKINE PRODUCTION; DOWN REGULATION; GENE MUTATION; GERM LINE; HELPER CELL; HUMAN; HYPERSENSITIVITY; IMMUNITY; IMMUNOGLOBULIN PRODUCTION; MYCOBACTERIOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; REVIEW; SALMONELLA; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ANIMALS; HUMANS; HYPERSENSITIVITY, IMMEDIATE; INTERLEUKIN-12; MUTATION; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12;

EID: 0035724911     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2001.01156.x     Document Type: Review

References (39)

1. Structure and expression of germline epsilon transcripts in human B cells induced by inlerleukin-4 to switch to IgE production
2. IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants
3. A T cell activity that enhances polyclonal IgE production and its inhibition interferon-gamma
4. Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production
5. Interferon-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses
6. IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2
7. The functionally distinct subpopulations of human CD4+ helper/inducer T lymphocytes defined by anti-CD45R antibodies derive sequentially from a differentation pathway that is regulated by activation-dependent post-thymic differentiation
8. Two types of murine helper T cell clone: I. Definition according to profiles of lymphokine activities and secreted proteins
9. Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties
10. Evidence for compartmentalization of functional subsets of CD4+ T Iymphocytes in atopic patients
11. Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis
12. Interleukin-4 and interferon-gamma production in atopic and non-atopic children with asthma
13. The production of interferon-gamma in response to a major peanut allergy, Ara h II correlates with serum levels of IgE anti-Ara h II
14. Serum IgE level is negatively correlated with the ability of peripheral mono-nuclear cells to produce interferon gamma (IFN-γ): Evidence of reduced expression of IFN- mRNA in atopic patients
15. The role of helper T lymphocytes in food allergy
16. Relationship between interferon-γ, interleukin-4 and IgE production of lymphocytes from he's egg-sensitive patients
17. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
18. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1) -specific immune responses and inhibits the development of IL-4-producing Th cells
19. Interleukin-12. A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
20. Interleukin-12. A pivotal regulator of cell-mediated immunity
21. Interleukin-12 an integral cytokine in the immune response
22. IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses
23. Induction of interferon gamma production by natural killer cell stimulatory factor: Characterization of the responder cells and synergy with other inducers
24. B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation
25. Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo
26. A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits
27. IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-γ promoter in primary CD4 T lymphocytes
28. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
29. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat) 3 and Stat4
30. Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency
31. Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients
32. Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1) -deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor
33. Mutations of the IL-12 receptor β2 chain gene in atopic subjects
34. Reduced IFN-gamma production in response to IL-12 stimulation and/or reduced IL-12 production in atopic patients
35. Genomic organization of the human interleukin-12 receptor beta2-chain gene
36. Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor
37. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor
38. Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma
39. Atopy and asthma: Genetic variants of IL-4 and IL-13 signalling