A role for protein kinase intracellular messengers in substance P- and nociceptor afferent-mediated excitation and expression of the transcription factor Fos in rat dorsal horn neurons in vitro

European Journal of Neuroscience

Volumn 14, Issue 3, 2001, Pages 426-434

  Badie Mahdavi, H ^a   Worsley, M A ^a   Ackley, M A ^a   Asghar, A U R ^a   Slack, J R ^a,b   King, A E ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 1H INDOLYL 3 YL] 3 (1H INDOL 3 YL)MALEIMIDE; BISINDOLYLMALEIMIDE; CYCLIC 3',5' HYDROGEN PHOSPHOROTHIOATE ADENOSINE TRIETHYLAMMONIUM; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; PHYSALAEMIN[9 DEXTRO PROLINE SPIRO GAMMA LACTAM 10 LEUCINE 11 TRYPTOPHAN]; PROTEIN FOS; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; SUBSTANCE P ANTAGONIST; SUBSTANCE P RECEPTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; DORSAL ROOT; DOSE RESPONSE; DRUG EFFECT; DRUG SELECTIVITY; ELECTROPHYSIOLOGY; ENZYME INHIBITION; EXCITATORY POSTSYNAPTIC POTENTIAL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; NERVE CELL STIMULATION; NEUROMODULATION; NOCICEPTION; NOCICEPTIVE RECEPTOR; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SECOND MESSENGER; SENSORY NERVE; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; SUBSTANCE P AGONIST;

ANIMALS; ELECTROPHYSIOLOGY; GENE EXPRESSION REGULATION; GENES, FOS; MALE; NEURONS, AFFERENT; NOCICEPTORS; PATCH-CLAMP TECHNIQUES; POSTERIOR HORN CELLS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, WISTAR; RECEPTORS, NEUROKININ-1; SECOND MESSENGER SYSTEMS; SUBSTANCE P; SYNAPSES;

EID: 0035724497     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0953-816X.2001.01656.x     Document Type: Article

References (54)

1. 1 receptors in bullfrog sensory neurons
2. Transsynaptic control of gene expression
3. Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways
4. Actions of intrathecal diphtheria toxin-substance P fusion protein on models of persistent pain
5. 1 receptor and the actions of tachykinin agonists in the dorsal horn of the rat indicates that substance P does not have a functional role on substantia gelatinosa (lamina II) neurons
6. Morphological characterization of substance P receptor-immunoreactive neurons in the rat spinal cord and trigeminal nucleus caudalis
7. Physiological contributions of neurokinin 1 receptor activation, and interactions with NMDA receptors, to inflammatory-evoked spinal c-Fos expression
8. Contribution of protein kinase C to central sensitization and persistent pain following tissue injury
9. Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model
10. Altered nociception, analgesia and aggression in mice lacking the receptor for substance P
11. Probing the cyclic-nucleotide binding-sites of cAMP-dependent protein kinase-I and protein kinase-II with analogs of adenosine 3́,5́- cyclic phosphorothioates
12. Substance P receptor (neurokinin-1) -expressing neurons in lamina I of the spinal cord encode for the intensity of noxious stimulation: A c-Fos study in rat
13. Calcium regulation of gene expression in neuronal cells
14. The regulation of prodynorphin gene expression in cultured spinal cord cells: Involvement of second messengers
15. A spirolactam conformationally-constrained analogue of physalaemin which is a peptidase -resistant, selective neurokinin NK-1 receptor antagonist
16. Substance P elevates intracellular calcium in both neurons and glial cells from the dorsal horn of the spinal cord
17. Immediate early genes (IEGs) encoding for inducible transcription factors (ITFs) and neuropeptides in the nervous system: Functional network for long-term plasticity and pain
18. Modulation of ion-channel function by G-protein-coupled receptors
19. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
20. Neonatal capsaicin treatment attenuates spinal Fos activation and dynorphin gene expression following peripheral tissue inflammation and hyperalgesia
21. C-fos can be induced in the neonatal rat spinal cord by both noxious and innocuous peripheral stimulation
22. Phosphorylation of transcription factor CREB in rat spinal cord after formalin-induced hyperalgesia: Relationship to c-fos induction
23. Regulation of potassium channels by protein kinases
24. Tachykinins: Receptor to effector
25. Profile of neuronal excitation following selective activation of the neurokinin-1 receptor in rat deep dorsal horn in vitro
26. Tachykinin actions on deep dorsal horn neurons in vitro: An electrophysiological and morphological study in the immature rat
27. CREB: A message to remember
28. Neuropeptides in morphologically and functionally identified primary afferent neurons in dorsal root ganglia; substance P, CGRP and somatostatin
29. The types of neuron in spinal dorsal horn which possess neurokinin-1 receptors
30. CGP 41251 and tamoxifen selectively inhibit mitogen-activated protein kinase activation and c-Fos phosphoprotein induction by substance P in human astrocytoma cells
31. Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase
32. Preserved acute pain and reduced neuropathic pain in mice lacking PKC-gamma
33. Expression of alpha-, beta- and gamma-subspecies of protein kinase C in the motor neurons in the embryonic and postnatal rat spinal cord
34. Molecular biology of pain
35. Evidence for a role of protein kinase C in the sustained activation of rat dorsal horn neurons evoked by cutaneous mustard oil application
36. The role of neurokinin and N-methyl-D-aspartate receptors in synaptic transmission from capsaicin-sensitive primary afferents in the rat spinal cord in vitro
37. 2 receptors contribute to C-fibre evoked slow potentials in the spinal cord
38. Signal transduction and ligand-binding domains of the tachykinin receptors
39. Preproenkephalin mRNA in spinal dorsal horn neurons is induced by peripheral inflammation and is co-localized with Fos and Fos- related proteins
40. Dynorphin expression and Fos-like immunoreactivity following inflammation induced hyperalgesia are colocalized in spinal cord neurons
41. Substance P: Ionic basis for depolarizing responses of mouse spinal cord neurons in cell cultures
42. The types of neuron which contain protein kinase C gamma in rat spinal cord
43. Activation of the cAMP transduction cascade contributes to the mechanical hyperalgesia and allodynia induced by intradermal injection of capsaicin
44. Inhibitors of G-proteins and protein kinases reduce the sensitization to mechanical stimulation and the desensitization to heat of spinothalamic tract neurons induced by intradermal injection of capsaicin in the primate
45. The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin
46. Substance P raises neuronal membrane excitability by reducing inward rectification
47. Activity-dependent changes in rat ventral horn neurons in vitro; summation of prolonged afferent evoked postsynaptic depolarizations produce a d-APV sensitive windup
48. The Bisindolylmaleimide GF-109203X is a potent and selective inhibitor of protein-kinase-C
49. 11]-SP, a new selective ligand for the NK-1 receptor in the central nervous system
50. Inhibition of spinal protein kinase C blocks substance P-mediated hyperalgesia
51. Molecular events in the spinal cord following sensory stimulation
52. 3H-phorbol 12,13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase C
53. The induction of Fos-like immunoreactivity by noxious thermal, mechanical and chemical stimuli in the lumbar spinal cord of infant rats
54. c-fos expression in isolated rat spinal cord