Novel positive allosteric modulators of GABAA receptors

Drugs of the Future

Volumn 26, Issue 12, 2001, Pages 1191-1197

  Sigel, E ^a   Dodd, R H ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; BENZODIAZEPINE DERIVATIVE; BETA CARBOLINE DERIVATIVE; BICUCULLINE; FLUMAZENIL; LORECLEZOLE; MUSCIMOL; NEUROSTEROID; PENTOBARBITAL; PICROTOXIN; ROD 163A; ROD 163B; ROD 164A; ROD 164B; ROD 166A; ROD 166B; ROD 173A; ROD 173B; ROD 178B; ROD 185; ROD 188; ROD 213A; ROD 213B; ROD 222; ROD 259; ROD 70A; ROD 70B; TERT BUTYLBICYCLOPHOSPHOROTHIOATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALLOSTERISM; DRUG BINDING; DRUG MECHANISM; DRUG STRUCTURE; NONHUMAN; REVIEW; XENOPUS;

EID: 0035714672     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2001.026.12.639536     Document Type: Review

References (43)

1. A γ-aminobutyric acid/benzodiazepine receptor complex from bovine cerebral cortex. Purification and partial characterization
2. A receptor channels
3. A receptor research
4. A receptor subunit
5. A receptor subunit in tissues of the reproductive system
6. A receptors: Classification on the basis of subunit structure and receptor function
7. Theta, a novel γ-aminobutyric acid type A receptor subunit
8. A receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus
9. A receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon
10. Distribution, prevalence, and drug binding profile of γ-aminobutyric acid type A receptor subtypes differing in the β-subunit variant
11. A receptor subunit for benzodiazepine pharmacology
12. A receptor subtypes
13. A receptors
14. A receptor: The action of (+)-ROD188
15. A receptor
16. A receptor with a new mode of action
17. Differential crosstalk of ROD compounds with the benzodiazepine binding site
18. A receptor selective for a behavioural alcohol antagonist
19. A receptor β subunit
20. 3 subunits
21. A receptor subtypes
22. 1 subtype
23. Molecular and neuronal substrate for the selective attenuation of anxiety
24. A chloride channels and benzodiazepine binding sites in baculovirus infected insect cells
25. A receptor
26. Role of the β subunit in determining the pharmacology of human γ-aminobutyric acid type A receptors
27. Comparison of the pharmacological profiles of the hypnotic drugs, zaleplon and zolpidem
28. A receptor
29. Properties of single sodium channels translated by Xenopus oocytes after injection with messenger ribonucleic acid
30. A receptors on channel function
31. 2 subunit gene of γ-aminobutyric acid type A receptors
32. α-substituted γ-butyrolactones: New class of anticonvulsant drugs
33. Alkyl-substituted thiolo-, thiono- and dithio-γ-butyrolactones: New classes of convulsant and anticonvulsant agents
34. Synthesis and structure-activity studies of alkyl-substituted γ-butyrolactones and γ-thiobutyrolactones: Ligands for the picrotoxin receptor
35. A receptor function
36. Convulsant and anticonvulsant cyclopentanones and cyclohexanones
37. 3,3-Dialkyl and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones: A new class of anticonvulsant agents
38. Physiological regulation of the picrotoxin receptor by γ-butyrolactones and γ-thiobutyrolactones in cultured hippocampal neurons
39. A receptors
40. Lactone modulation of the γ-aminobutyric acid A receptor: Evidence for a positive modulatory site