Induction of intratumoral tumor necrosis factor by a synthetic lipid A analog, ONO-4007, with less tolerance in repeated administration and its implication in potent antitumor effects with low toxicity

Cancer Immunology, Immunotherapy

Volumn 50, Issue 12, 2002, Pages 653-662

  Satoh, Motonobu ^a   Tsurumaki, Kazusa ^a   Kagehara, Hideaki ^a   Yamazaki, Masatoshi ^a   Dabadie, H ^b   Gin, H ^b  

^a TEIKYO UNIVERSITY   (Japan)

^b Service de Nutrition Diabe tologie   (France)

Author keywords

Anti tumor effects; Lipid A analog; Tolerance; Tumor infiltrating macrophages

Indexed keywords

2 DEOXY 3 O (9 PHENYLNONANOYL) 2 [3 (9 PHENYLNONANOYLOXY)TETRADECANOYLAMINO]GLUCOPYRANOSE 4 SULFATE; BACTERIAL PROTEIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; LA 15 PP; LIPID A DERIVATIVE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOMA; CANCER LOCALIZATION; CELL INFILTRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG POTENCY; DRUG REEXPOSURE; DRUG STABILITY; DRUG TOLERANCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR ASSOCIATED LEUKOCYTE;

ANIMALS; ANTINEOPLASTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; LIPID A; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035711209     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-001-0241-7     Document Type: Article

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