Intratumoral tumor necrosis factor induction and tumor growth suppression by ONO-4007, a low-toxicity lipid A analog

Anticancer Research

Volumn 18, Issue 6 A, 1998, Pages 4283-4289

  Matsumoto, Norihito ^a   Oida, Hiroji ^a   Aze, Yoshiya ^a   Akimoto, Akira ^a   Fujita, Tsuneo ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Antitumor effect; Lipopolysaccharide; ONO 4007; Tumor necrosis factor

Indexed keywords

2 DEOXY 3 O (9 PHENYLNONANOYL) 2 [3 (9 PHENYLNONANOYLOXY)TETRADECANOYLAMINO]GLUCOPYRANOSE 4 SULFATE; LIPID A DERIVATIVE; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HEPATOMA CELL; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIBODIES; ANTINEOPLASTIC AGENTS; CELL DIVISION; DICLOFENAC; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; INDOMETHACIN; INJECTIONS, INTRAVENOUS; LIPID A; LIPOPOLYSACCHARIDES; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; RABBITS; RATS; RATS, INBRED STRAINS; SPLEEN; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032409676     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Kanegasaki S, Tanamoto K, Yasuda T, Homma JY, Matsuura M, Nakatsuka M, Kumazawa Y, Yamamoto A, Shiba T, Kusumoto S, Imoto M, Yoshimura H and Shimamoto T: Structure-activity relationship of lipid A: comparison of biological activities of natural and synthetic lipid A's with different fatty acid compositions. J Biochem 99: 1203-1210, 1986.
2. Matsuura M, Shimada S, Kiso M, Hasegawa A and Nakano M: Expression of endotoxic activities by synthetic monosaccharide lipid A analogs with alkyl-branched acyl substituents. Infect Immun 63: 1446-1451, 1995.
3. Ulrich JT and Myers KR: Monophosphoryl lipid A as an adjuvant. Past experiences and new directions. Pharm Biotechnol 6: 495-524, 1995.
4. Kotani S, Takada H, Tsujimoto M, Ogawa T, Mori Y, Sakuta M, Kawasaki A, Inage M, Kusumoto S, Shiba T and Kasai N: Immunobiological activities of synthetic lipid A analogs and related compounds as compared with those of bacterial lipopolysaccharide, Re-glycolipid, lipid A, and muramyl dipeptide. Infect Immun 41: 758-773, 1983.
5. Schutze E, Hildebrandt J, Liehl E and Lam C: Protection of mice from mortality caused by living and heat-killed bacteria by SDZ MRL 953. Circ Shock 42: 121-127, 1994.
6. Nakatsuka M, Kumazawa Y, Matsuura M, Homma JY, Kiso M and Hasegawa A: Enhancement of nonspecific resistance to bacterial infections and tumor regressions by treatment with synthetic lipid A-subunit analogs. Critical role of N- and 3-O-linked acyl groups in 4-O-phosphono-D-glucosamine derivatives. Int J Immunopharmacol 11: 349-358, 1989.
7. Yang D, Satoh M, Ueda H, Tsukagoshi S and Yamazaki M: Activation of tumor-infiltrating macrophages by a synthetic lipid A analog (ONO-4007) and its implication in antitumor effects. Cancer Immunol Immunother 38: 287-293, 1994.
8. + αβ T cells with potent cytotoxicity in the liver of mice via production of IL-12 from Kupffer cells. J Immunol 156: 2436-3442, 1996.
9. Matsumoto N, Aze Y, Akimoto A and Fujita T: Restoration of immune responses in tumor-bearing mice by ONO-4007, an antitumor lipid A derivative. Immunopharmacol 36: 69-78, 1997.
10. Engelhardt R, Mackensen A and Galanos C: Phase I trial of intravenously administered endotoxin (Salmonella abortus equi) in cancer patients. Cancer Res 51: 2524-2530, 1991.
11. Otto F, Schmid P, Mackensen A, Wehr U, Seiz A, Braun M, Galanos C, Mertelsmann, R. and Engelhardt, R: Phase II trial of intravenous endotoxin in patients with colorectal and non-small cell lung cancer. Eur J Cancer 32A: 1712-1718, 1996.
12. Sugiura C, Itaya T, Kondoh N, Oikawa T, Kuzumaki N, Takeichi N, Hosokawa M and Kobayashi H: Xenogenization of tumor fells by transfection with plasmid containing env gene of friend leukemia virus. Jpn J Cancer Res 79: 1259-1263, 1988.
13. Matsumoto N, Aze Y, Akimoto A and Fujita T: ONO-4007, an antitumor lipid A analog, induces tumor necrosis factor-α production by human monocytes only under primed state: different effects of ONO-4007 and lipopolysaccharide on cytokine production. J Pharm Exp Ther 284: 189-195, 1998.
14. Denizot F and Lang R: Rapid colorimetric assay for cell growth and survival: modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 89: 271-277, 1986.
15. de Waal Malefyt R, Abrams J, Bennett B, Figdor CG and de Vries JE: Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 174: 1209-1220, 1991.
16. 2-producing suppressor macrophages. Immunobiol 161: 385-391, 1982.
17. Eggermont AM, Schraffordt-Koops H, Lienard D, Kroon BB, Van-Geel AN, Hoekstra HJ and Lejeune FJ: Isolated limb perfusion with high-dose tumor nacrosis-α in combination with interferon-γ and melphalan for nonresectable extremity soft tissue sarcomas: a multicenter trial. J Clin Oncol 14: 2653-2665, 1996.
18. Wright SD, Ramos RA, Tobias PS, Ulevitch RJ and Mathison JC: CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249: 1431-1433, 1990.
19. Michie HR, Manogue KR, Spriggs DR, Revhaug A, O'Dwyer S, Dinarello CA, Cerami A, Wolff SM and Wilmore DW: Detection of circulating tumor necrosis factor after endotoxin administration. N Eng J Med 318: 1481-1486, 1988.
20. Martich GD, Danner RL, Ceska M and Suffredini AF: Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents. J Exp Med 173: 1021-1024, 1991.
21. Boujoukos AJ, Martich GD, Supinski E and Suffredini AF: Compartmentalization of the acute cytokine response in humans after intravenous endotoxin administration. J Appl Physiol 76: 3027-3033, 1993.