Measle virus-infected dendritic cells develop immunosuppressive and cytotoxic activities

Immunobiology

Volumn 204, Issue 5, 2001, Pages 629-638

  Vidalain, Pierre Olivier ^a   Azocar, Olga ^a   Rabourdin Combe, Chantal ^a   Servet Delprat, Christine ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; FAS LIGAND; INTERFERON; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANIMAL CELL; ARTICLE; CELL DESTRUCTION; CELL FUNCTION; CHILD; CONTROLLED STUDY; CYTOTOXICITY; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOBIOLOGY; LYMPHOCYTOPENIA; LYMPHOID ORGAN; MALNUTRITION; MEASLES VIRUS; MORTALITY; NONHUMAN; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; RESPIRATORY TRACT MUCOSA; VIRUS INFECTION;

EID: 0035711188     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1078/0171-2985-00102     Document Type: Article

References (38)

1. Generalized immunosuppression: Individual viruses, intertwined targets
2. Extensive lymphopenia due to apoptosis of uninfected lymphocytes in acute measles patients
3. Infection of monocytes during measles
4. Programmed cell death in peripheral lymphocytes from HIV-infected persons: Increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression
5. Dendritic cell lineage, plasticity and cross-regulation
6. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
7. Activation of human dendritic cells through CD40 cross-linking
8. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
9. High level IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10
10. CD40 and CD154 in cell-mediated immunity
11. Help for cytotoxic-T-cell responses is mediated by CD40 signalling
12. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
13. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
14. Measles virus suppresses cell-mediated immunity by interfering with the survival and functions of dendritic and T cells
15. Measles virus infects human dendritic cells and blocks their allostimulatory properties for CD4+ T cells
16. Induction of maturation of human blood dendritic cell precursors by measles virus is associated with immunosuppression
17. Langerhans cells are susceptible to measles virus infection and actively suppress T cell proliferation
18. Measles virus induces abnormal differentiation of CD40 ligand-activated human dendritic cells
19. Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus
20. CD40 ligand inhibits Fas/CD95-mediated apoptosis of human blood-derived dendritic cells
21. CD40 ligation counteracts Fas-induced apoptosis of human dendritic cells
22. Cell cycle arrest during measles virus infection: A G0-like block leads to suppression of retinoblastoma protein expression
23. Measles virus infection of B lymphocytes permits cellular activation but blocks progression through the cell cycle
24. Disruption of Akt kinase activation is important for immunosuppression induced by measles virus
25. Measles virus induces functional TRAIL production by human dendritic cells
26. Identification and characterization of a new member of the TNF family that induces apoptosis
27. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
28. IFN-gamma mediates a novel antiviral activity through dynamic modulation of TRAIL and TRAIL receptor expression
29. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression
30. Human dendritic cells mediate cellular apoptosis via tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
31. The involvement of TNF-alpha-related apoptosis-inducing ligand in the enhanced cytotoxicity of IFN-beta-stimulated human dendritic cells to tumor cells
32. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis
33. Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation
34. Rat spleen dendritic cells express natural killer cell receptor protein 1 (NKR-P1) and have cytotoxic activity to select targets via a Ca2+-dependent mechanism
35. A subset of cytolytic dendritic cells in rat
36. Nonhuman primate models of measles
37. Experimental measles. I. Pathogenesis in the normal and the immunized host
38. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs