Nitric oxide production by Leishmania-infected macrophages and modulation by prostaglandin E2

Clinical and Experimental Medicine

Volumn 1, Issue 3, 2001, Pages 137-143

  Panaro, M A ^a   Brandonisio, O ^b   Sisto, M ^a   Acquafredda, A ^a   Leogrande, D ^b   Fumarola, L ^b   Mitolo, V ^a  

^a UNIVERSITY OF BARI   (Italy)

^b POLICLINICO   (Italy)

Author keywords

Killing; Leishmaniasis; Macrophage; Nitric oxide; Prostaglandins

Indexed keywords

ARACHIDONIC ACID; BACTERIUM LIPOPOLYSACCHARIDE; CYCLOOXYGENASE 2; GAMMA INTERFERON; INDOMETACIN; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN E2; RECOMBINANT CYTOKINE;

ANTIPARASITIC ACTIVITY; ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; ENZYME ACTIVATION; HOST; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LEISHMANIA; MACROPHAGE; NORMAL HUMAN; PARASITOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM;

BACTERIA (MICROORGANISMS); LEISHMANIA INFANTUM;

EID: 0035709653     PISSN: 15918890     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10238-001-8025-0     Document Type: Article

References (25)

1. Nitric oxide: A cytotoxic activated macrophages effector molecule
2. Activated macrophages destroy Leishmania major amastigotes by an L-arginine-dependent killing mechanism
3. Killing of Leishmania parasites in activated murine macrophages is based on an L-arginine-dependent process that produces nitrogen derivates
4. Down-regulation of MARKS-related protein (MRP) in macrophages infected with Leishmania
5. Inducible nitric oxide synthase and nitric oxide production in Leishmania infantum-infected human macrophages stimulated with interferon-γ and bacterial lipopolysaccharide
6. Effect of PGE2 and of agents that raise cAMP levels on macrophage activation induced by IFN-γ and TNF-α
7. Modulation of inducible nitric oxide synthase induction by prostaglandin E2 in macrophages: Distinct susceptibility in murine J774 and RAW 264.7 macrophages
8. Prostaglandin E(2) regulates inducible nitric oxide synthase in the murine macrophage cell line J774
9. Indomethacin prevents the induction of inducible nitric oxide synthase in murine peritoneal macrophages and decreases their nitric oxide production
10. Cytochemical identification of monocytes and granulocytes
11. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: Comparison of activating cytokines and evidence for independent production
12. Prostaglandins prevent inducible nitric oxide synthase protein expression by inhibiting nuclear factor-kB activation in J774 macrophages
13. Nuclear factor kB is activated by arachidonic acid but not by eicosapentaenoic acid
14. Pyrimidinoceptor potentiation of macrophages PGE(2) release involved in the induction of nitric oxide synthase
15. The mouse macrophage activation-associated marker protein, p71/73, is an inducible prostaglandin endoperoxide synthase (cyclooxygenase)
16. Transient expression of prostaglandin endoperoxide synthase-2 during mouse macrophage activation
17. Involvement of p38 mitogen-activated protein kinase in lipopolysaccharide-induced iNOS and COX-2 expression in J774 macrophages
18. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages
19. Prostaglandin levels in stimulated macrophages are controlled by phospholipase A2-activated protein and by activation of phospholipase C and D
20. Regulation of the expression of the inflammatory nitric oxide synthase (NOS2) by cyclic AMP
21. An increase in intracellular cyclic AMP modulates nitric oxide production in IFN-gamma-treated macrophages
22. Regulation of cyclooxygenase-2 expression by nitric oxide in cells
23. Increased antimycobacterial immunity in interleukin-10-deficient mice
24. Nitric oxide production in murine leishmaniasis: Correlation of progressive infection with increasing systemic synthesis of nitric oxide
25. Nitric oxide (NO)-related pharmaceutical: Contemporary approaches to therapeutic NO modulation