Hypothesis to explain poor outcomes in the ALLHAT and V-HeFT trials: Decreased expression of heat shock proteins

Current Controlled Trials in Cardiovascular Medicine

Volumn 2, Issue 6, 2001, Pages 251-253

  Hooper, Philip L ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLURAPIDIL; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CHLOROETHYLCLONIDINE; CHLORTALIDONE; DOXAZOSIN; HEAT SHOCK PROTEIN; HIGH DENSITY LIPOPROTEIN; INSULIN; NORADRENALIN; PRAZOSIN; TAMSULOSIN; TERAZOSIN; TRIACYLGLYCEROL; VASODILATOR AGENT;

ADRENERGIC ACTIVITY; AGING; ALCOHOL CONSUMPTION; APOPTOSIS; CARDIOVASCULAR RISK; CARDIOVASCULAR SYSTEM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIABETES MELLITUS; DOUBLE BLIND PROCEDURE; DRUG WITHDRAWAL; ENDOTHELIUM; EXERCISE; FOLLOW UP; HEART FAILURE; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HUMAN; HYPERTENSION; HYPOTHESIS; INSULIN SENSITIVITY; METABOLISM; MORTALITY; MOUSE; NONHUMAN; NOTE; OUTCOMES RESEARCH; OXIDATION; PROSTATE HYPERTROPHY; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN SYNTHESIS; RANDOMIZED CONTROLLED TRIAL; STRESS; TRANSGENIC MOUSE;

EID: 0035702786     PISSN: 14686708     EISSN: None     Source Type: Journal    
DOI: 10.1186/CVM-2-6-251     Document Type: Note

References (21)

1. Major cardiovascular events in hypertensive patients randomized to doxazosin vs chorthalidone
2. Effect of vasodilator therapy on mortality in chronic congestive heart failure. Results of a Veterans Administration Cooperative Study
3. Effects of doxazosin and atenolol on atherothrombogenic risk profile in hypertensive middle-aged men
4. Stress (heat shock) proteins - Molecular chaperones in cardiovascular biology and disease
5. Cold-induced heat shock protein expression in rat aorta and brown adipose tissue
6. 1 adrenoreceptors
7. 1a-adrenoreceptors in rabbits
8. Right heart failure chronically stimulates heat shock protein 72 in heart and liver but not in other tissues
9. Protective effect of heat shock protein 72 on contractile function of perfused failing heart
10. Bimoclomol: A nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects
11. Effect of subchronic bimoclomol treatment on vascular responsiveness heat shock protein production in spontaneously hypertensive rats
12. Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction
13. Reduction in myocardial apoptosis associated with overexpression of heat shock protein 70
14. Heat shock proteins: New keys to the development of cytoprotective therapies
15. Alpha 1-adrenoceptor antagonists terazosin and doxazosin induce prostate apoptosis without affecting cell proliferation in patients with benign prostatic hyperplasia
16. Long-term, open-label, phase III multicenter study of tamsulosin in benign prostatic hyperplasia
17. Health outcomes associated with calcium antagonists compared with other first-line antihypertensive therapies: A meta-analysis of randomized controlled trials
18. Effects of calcium channel blockers on stress protein synthesis in cardiac myocytes
19. Risk of gastrointestinal haemorrhage with calcium antagonists in hypertensive persons over 67 years old
20. Role of heat shock proteins in gastric mucosal protection
21. Evaluating adverse cardiovascular effects of drug treatment for benign prostatic hyperplasia (BPH): Methodological considerations