Risk of gastrointestinal haemorrhage with calcium antagonists in hypertensive persons over 67 years old

Lancet

Volumn 347, Issue 9008, 1996, Pages 1061-1065

  Pahor, Marco ^a   Guralnik, Jack M ^b   Furberg, Curt D ^c   Carbonin, Pierugo ^a   Havlik, Richard J ^b  

^a CATHOLIC UNIVERSITY   (Italy)

^b Laboratory of Membrane Biochemistry and Biophysics   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; DILTIAZEM; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; NIFEDIPINE; VERAPAMIL;

AGED; ARTERIAL PRESSURE; ARTICLE; COHORT ANALYSIS; DEATH; GASTROINTESTINAL HEMORRHAGE; HIGH RISK PATIENT; HOSPITAL DISCHARGE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK; THROMBOCYTE AGGREGATION INHIBITION; TREATMENT OUTCOME;

EID: 0029873619     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(96)90276-7     Document Type: Article

References (30)

1. Zucker ML, Budd SE, Dollar LE, Chernoff SB, Altman R. Effect of diltiazem and low-dose aspirin on platelet aggregation and ATP release induced by paired agonists. Thromb Haemost 1993; 70: 332-35.
2. Pales J, Palacios-Araus L, Lopez A, Gaul A. Effects of dihydropyridines and inorganic calcium blockers on aggregation and on intracellular free calcium in platelets. Biochim Biophys Acta 1991; 1064: 169-74.
3. Wallen NH, Held C, Rehnqvist N, Hjemdahl P. Platelet aggregability in vivo is attenuated by verapamil but not by metoprolol in patients with stable angina pectoris. Am J Cardiol 1995; 75: 1-6.
4. Wagenknecht LE, Furberg CD, Hammon JW, Legault C, Troost BT. Surgical bleeding: unexpected effect of a calcium antagonist. BMJ 1995; 310: 776-77.
5. Gore JM, Sloan M, Price TR, et al. Intracerebral hemorrhage, cerebral infarction, and subdural hematoma after acute myocardial infarction and thrombolytic therapy in the Thrombolysis in Myocardial Infarction study. Thrombolysis in myocardial infarction, phase II, pilot and clinical trial. Circulation 1991; 83: 448-59.
6. Kario K, Imiya M, Ohat Y, Shimada K. Gastrointestinal bleeding induced by amlodipine. J Hum Hypertens 1995; 9: 206-07.
7. Pahor M, Guralnik JM, Corti C, Foley DJ, Carbonin PU, Havlik RJ. Long-term survival and use of antihypertensive medications in older persons. J Am Geriatr Soc 1995; 43: 1191-97.
8. Furberg CD, Psaty BM, Meyer JV. Nifedipine. Dose-related increase in mortality in patients with coronary heart disease. Circulation 1995; 92: 1326-31.
9. Gilbert DA. Epidemiology of upper gastrointestinal bleeding. Gastrointest Endosc 1990; 36: S8-13.
10. Pahor M, Guralnik JM, Salive ME, Chrischilles EA, Wallace RB. Disability and severe gastrointestinal hemorrhage. A prospective study of community dwelling older persons. J Am Geriatr Soc 1994; 42: 816-25.
11. Pahor M, Guralnik JM, Salive ME, Chrischilles EA, Brown SL, Wallace RB. Physical activity and risk of severe gastrointestinal hemorrhage in older persons. JAMA 1994; 272: 595-99.
12. Hudson N, Faulkner G, Smith SJ, Langman MJS, Hawkey CJ, Logan RFA. Late mortality in elderly patients surviving acute peptic ulcer bleeding. Gut 1995; 37: 177-81.
13. Cornoni-Huntley J, Ostfeld AM, Taylor JO, et al. Established populations for epidemiologic studies of the elderly: study design and methodology. Aging Clin Exp Res 1993; 5: 27-37.
14. Psaty BM, Lee M, Savage PJ, Rutan GH, German PS, Lyles M. Assessing the use of medications in the elderly: methods and initial experience in the Cardiovascular Health Study. The Cardiovascular Health Study Collaborative Research Group. J Clin Epidemiol 1992; 45: 683-92.
15. Landry JA, Smyer MA, Tubman JG, Lago DJ, Roberts J, Simonson W. Validation of two methods of data collection of self-reported medicine use among the elderly. Gerontologist 1988; 28: 672-76.
16. Pahor M, Chrischilles EA, Guralnik JM, Brown SL, Wallace RB, Carbonin PU. Drug data coding and analysis in epidemiologic studies. Eur J Epidemiol 1994; 10: 405-11.
17. Hypertension Detection and Follow-up Program Cooperative Group. Blood pressure studies in 14 communities: a two-stage screen for hypertension. JAMA 1977; 237 2385-91.
18. International Classification of Diseases, 9th revision, clinical modification. Washington: Public Health Service - Health Care Financing Administration, 1980.
19. Rose GA, Blackburn H, Gillum RF, Prineas RJ. Annex 6 - London School of Hygiene cardiovascular questionnaire. In: World Health Organization, ed. Cardiovascular survey methods, 2nd ed. Geneva: WHO, 1982: 162-65.
20. Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial function. JAMA 1963; 185: 94-99.
21. Rosow I, Breslau N. A Guttman health scale for the aged. J Gerontol 1966; 21: 556-59.
22. Cutler SJ, Ederer F. Maximum utilization of the life-table method in analyzing survival. J Chronic Dis 1958; 8: 699-713.
23. Cox DR. Regression models and life tables. J R Statist Soc 1972; 34B: 187-220.
24. SPSS advanced statistics reference guide. Release 6.0. Chicago: SPSS, 1993.
25. Blache D, Ojeda C. Comparative inhibitory effects of dihydropyridines on platelet aggregation, calcium uptake and cyclic AMP concentration. Pharmacology 1992; 45: 250-59.
26. Berkels R, Klaus W, Boller M, Rosen R. The calcium modulator nifedipine exerts its antiaggregatory property via a nitric oxide mediated process. Thromb Haemost 1994; 72: 309-12.
27. Konrad Dalhoff I, Baunack AR, Ramsch KD, et al. Effect of the calcium antagonists nifedipine, nitrendipine, nimodipine and nisoldipine on oesophageal motility in man. Eur J Clin Pharmacol 1991; 41: 313-16.
28. Conn HO, Grace ND, Bosch J, et al. Propranolol in the prevention of the first hemorrhage from esophagogastric varices: a multicenter, randomized clinical trial. The Boston-New Haven-Barcelona Portal Hypertension Study Group. Hepatology 1991; 13: 902-12.
29. Dahlof B, Hansson L, Lindholm LH, et al. STOP-Hypertension 2: a prospective intervention trial of "newer" versus "older" treatment alternatives in old patients with hypertension. Blood Presssure 1993; 2: 136-41.
30. Davis BR, Cutler JA, Gordon DJ, et al. Rationale and design for the Antihypertensive and Lipid Lowering treatment to prevent Heart Attack Trial (ALLHAT). Am J Hypertens (in press).