메뉴 건너뛰기




Volumn 161, Issue 6, 1999, Pages 2002-2008

α1-Adrenoceptor antagonists terazosin and doxazosin induce prostate apoptosis without affecting cell proliferation in patients with benign prostatic hyperplasia

Author keywords

Apoptosis; Cell proliferation; Doxazosin; Prostate; Terazosin; adrenoceptor antagonists

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; DOXAZOSIN; TERAZOSIN;

EID: 0032861498     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(05)68873-8     Document Type: Article
Times cited : (136)

References (36)
  • 1
    • 0032426688 scopus 로고    scopus 로고
    • Induction of prostate apoptosis by doxazosin in benign prostatic hyperplasia
    • Kyprianou, N., Litvak, J. P., Borkowski, A., Alexander R. and Jacobs, S. C.: Induction of prostate apoptosis by doxazosin in benign prostatic hyperplasia, J. Urol., 159: 1810, 1998.
    • (1998) J. Urol. , vol.159 , pp. 1810
    • Kyprianou, N.1    Litvak, J.P.2    Borkowski, A.3    Alexander, R.4    Jacobs, S.C.5
  • 2
    • 0031874019 scopus 로고    scopus 로고
    • The pathophysiology of lower urinary tract symptoms in the ageing male population
    • Lepor, H.: The pathophysiology of lower urinary tract symptoms in the ageing male population. Br. J. Urol., 81: 29, 1998.
    • (1998) Br. J. Urol. , vol.81 , pp. 29
    • Lepor, H.1
  • 3
    • 0029684668 scopus 로고    scopus 로고
    • Benign prostatic hyperplasia: A review of its histogenesis and natural history
    • Oesterling, J. E.: Benign prostatic hyperplasia: a review of its histogenesis and natural history. Prostate (Suppl.), 6: 67, 1996.
    • (1996) Prostate (Suppl.) , vol.6 , pp. 67
    • Oesterling, J.E.1
  • 4
    • 0018150495 scopus 로고
    • Origin and evolution of benign prostatic enlargement
    • McNeal, J. E.: Origin and evolution of benign prostatic enlargement. Invest. Urol., 15: 340, 1978.
    • (1978) Invest. Urol. , vol.15 , pp. 340
    • McNeal, J.E.1
  • 5
    • 0024214094 scopus 로고
    • Alpha-adrenergic mechanisms in dynamics of benign prostatic hypertrophy
    • Caine, M.: Alpha-adrenergic mechanisms in dynamics of benign prostatic hypertrophy. Urology, 32: 16, 1988.
    • (1988) Urology , vol.32 , pp. 16
    • Caine, M.1
  • 6
    • 0025028657 scopus 로고
    • Medical management of benign prostatic hyperplasia with androgen suppression
    • McConnell, J. D.: Medical management of benign prostatic hyperplasia with androgen suppression, Prostate (Suppl.), 3: 49, 1990.
    • (1990) Prostate (Suppl.) , vol.3 , pp. 49
    • McConnell, J.D.1
  • 7
    • 0024832529 scopus 로고
    • Etiology and disease process of benign prostatic hyperplasia
    • Isaacs, J. T. and Coffey, D. S.: Etiology and disease process of benign prostatic hyperplasia. Prostate (Suppl.), 2: 33, 1989.
    • (1989) Prostate (Suppl.) , vol.2 , pp. 33
    • Isaacs, J.T.1    Coffey, D.S.2
  • 8
    • 0023227737 scopus 로고
    • The effect of nafarelin acetate, a luteinizing-hormone-releasing hormone agonist, on benign prostatic hyperplasia
    • published erratum appears in N. Engl. J. Med. 3, 318: 580
    • Peters, C. A. and Walsh, P. C.: The effect of nafarelin acetate, a luteinizing-hormone-releasing hormone agonist, on benign prostatic hyperplasia [published erratum appears in N. Engl. J. Med. 3, 318: 580], N. Engl. J. Med., 317: 599, 1987.
    • (1987) N. Engl. J. Med. , vol.317 , pp. 599
    • Peters, C.A.1    Walsh, P.C.2
  • 9
    • 0027222669 scopus 로고
    • The alpha-adrenoceptor subtype mediating the tension of human prostatic smooth muscle
    • Lepor, H., Tang, R. and Shapiro, E.: The alpha-adrenoceptor subtype mediating the tension of human prostatic smooth muscle. Prostate, 22: 301, 1993.
    • (1993) Prostate , vol.22 , pp. 301
    • Lepor, H.1    Tang, R.2    Shapiro, E.3
  • 10
    • 0017076325 scopus 로고
    • The use of alpha-adrenergic blockers in benign prostatic obstruction
    • 1976
    • Caine, M., Pfau, A. and Perlberg, S.: The use of alpha-adrenergic blockers in benign prostatic obstruction. Br. J. Urol., 48: 255, 1976, 1976.
    • (1976) Br. J. Urol. , vol.48 , pp. 255
    • Caine, M.1    Pfau, A.2    Perlberg, S.3
  • 11
    • 0030969734 scopus 로고    scopus 로고
    • Prostatic alpha 1-adrenoceptors and uroselectivity
    • Andersson, K-E., Lepor, H. and Wyllie, M. G.: Prostatic alpha 1-adrenoceptors and uroselectivity. Prostate, 30: 202, 1997.
    • (1997) Prostate , vol.30 , pp. 202
    • Andersson, K.-E.1    Lepor, H.2    Wyllie, M.G.3
  • 13
    • 0027530990 scopus 로고
    • Alpha 1 adrenoceptor subtypes in the human prostate
    • Lepor, H., Tang, R., Meretyk, S. and Shapiro, E.: Alpha 1 adrenoceptor subtypes in the human prostate, J. Urol., 149: 640, 1993.
    • (1993) J. Urol. , vol.149 , pp. 640
    • Lepor, H.1    Tang, R.2    Meretyk, S.3    Shapiro, E.4
  • 15
    • 0031853559 scopus 로고    scopus 로고
    • 1-antagonists
    • 1-antagonists, Br. J. Urol., 81: 48, 1998.
    • (1998) Br. J. Urol. , vol.81 , pp. 48
    • Kawabe, K.1
  • 16
    • 0029002126 scopus 로고
    • Doxazosin in the treatment of benign prostatic hyperplasia in normotensive patients: A multicenter study
    • Fawzy, A., Braun, K., Lewis, G. P., Gaffney, M., Ice, K. and Dias, N.: Doxazosin in the treatment of benign prostatic hyperplasia in normotensive patients: a multicenter study [see comments]. J. Urol., 154: 105, 1995.
    • (1995) J. Urol. , vol.154 , pp. 105
    • Fawzy, A.1    Braun, K.2    Lewis, G.P.3    Gaffney, M.4    Ice, K.5    Dias, N.6
  • 17
    • 0029024313 scopus 로고
    • Doxazosin for the treatment of benign prostatic hyperplasia in patients with mild to moderate essential hypertension: A double-blind, placebo-controlled, dose-response multicenter study
    • Gillenwater, J. Y., Conn, R. L., Chrysant, S. G., Roy, J., Gaffney, M., Ice, K. and Dias, N.: Doxazosin for the treatment of benign prostatic hyperplasia in patients with mild to moderate essential hypertension: a double-blind, placebo-controlled, dose-response multicenter study [see comments]. J. Urol., 154: 110, 1995.
    • (1995) J. Urol. , vol.154 , pp. 110
    • Gillenwater, J.Y.1    Conn, R.L.2    Chrysant, S.G.3    Roy, J.4    Gaffney, M.5    Ice, K.6    Dias, N.7
  • 18
    • 0031021415 scopus 로고    scopus 로고
    • Doxazosin for benign prostatic hyperplasia: Long-term efficacy and safety in hypertensive and normotensive patients. the Multicenter Study Group
    • Lepor, H., Kaplan, S. A., Klimberg, I., Mobley, D. F., Fawzy, A., Gaffney, M., Ice, K. and Dias, N.: Doxazosin for benign prostatic hyperplasia: long-term efficacy and safety in hypertensive and normotensive patients. The Multicenter Study Group. J. Urol., 157: 525, 1997.
    • (1997) J. Urol. , vol.157 , pp. 525
    • Lepor, H.1    Kaplan, S.A.2    Klimberg, I.3    Mobley, D.F.4    Fawzy, A.5    Gaffney, M.6    Ice, K.7    Dias, N.8
  • 19
    • 0029045402 scopus 로고
    • Implication of cell cycle kinetic changes during the progresssion of human prostate cancer
    • Berges, R. R., Vucanovic, J., Epstein, J. I., Walsh, P. C. and Isaacs, J. T.: Implication of cell cycle kinetic changes during the progresssion of human prostate cancer., Clin. Cancer Res., 1: 473, 1995.
    • (1995) Clin. Cancer Res. , vol.1 , pp. 473
    • Berges, R.R.1    Vucanovic, J.2    Epstein, J.I.3    Walsh, P.C.4    Isaacs, J.T.5
  • 20
    • 0029899625 scopus 로고    scopus 로고
    • Apoptotic versus proliferative activities in human benign prostatic hyperplasia
    • Kyprianou, N., Tu, H. and Jacobs, S. C.: Apoptotic versus proliferative activities in human benign prostatic hyperplasia. Hum. Pathol., 27: 668,1996.
    • (1996) Hum. Pathol. , vol.27 , pp. 668
    • Kyprianou, N.1    Tu, H.2    Jacobs, S.C.3
  • 22
    • 0025835716 scopus 로고
    • BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death
    • Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M. and Korsmeyer, S. J.: BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. Nat. Acad. Sci. USA, 88: 6961, 1992.
    • (1992) Proc. Nat. Acad. Sci. USA , vol.88 , pp. 6961
    • Hockenbery, D.M.1    Zutter, M.2    Hickey, W.3    Nahm, M.4    Korsmeyer, S.J.5
  • 23
    • 0003427883 scopus 로고
    • Benign Prostatic Hyperplasia: Diagnosis and Treatment
    • Rockville, MD: Agency for Health Care Policy and Research, Public Health Service, US Department of Health and Human Services
    • McConnell, J. D., Barry, M. J. and Bruskewitz, R. C.: Benign Prostatic Hyperplasia: Diagnosis and Treatment. Clinical Practice Guideline. Rockville, MD: Agency for Health Care Policy and Research, Public Health Service, US Department of Health and Human Services, 1994.
    • (1994) Clinical Practice Guideline
    • McConnell, J.D.1    Barry, M.J.2    Bruskewitz, R.C.3
  • 24
    • 0026591918 scopus 로고
    • The American Urological Association symptom index for benign prostatic hyperplasia. the Measurement Committee of the American Urological Association
    • Barry, M. J., Fowler, F. J., Jr., Bruskewitz, R. C., Holtgrewe, H. L., Mebust, W. K. and Cockett, A. T.: The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association. J. Urol., 148: 1549, 1992.
    • (1992) J. Urol. , vol.148 , pp. 1549
    • Barry, M.J.1    Fowler F.J., Jr.2    Bruskewitz, R.C.3    Holtgrewe, H.L.4    Mebust, W.K.5    Cockett, A.T.6
  • 25
    • 0030891005 scopus 로고    scopus 로고
    • Effect of terazosin on prostatism in men with normal and abnormal peak urinary flow rates
    • Lepor, H., Nieder, A., Feser, J. and Dixon, C.: Effect of terazosin on prostatism in men with normal and abnormal peak urinary flow rates. Urology, 49: 476, 1997.
    • (1997) Urology , vol.49 , pp. 476
    • Lepor, H.1    Nieder, A.2    Feser, J.3    Dixon, C.4
  • 26
    • 9444268678 scopus 로고    scopus 로고
    • The efficacy of terazosin, finasteride, or both in benign prostatic hyperplasia. Veterans Affairs Cooperative Studies Benign Prostatic Hyperplasia Study Group
    • Lepor, H., Williford, W. O., Barry, M. J., Brawer, M. K., Dixon, C. M., Gormley, G., Haakenson, C., Machi, M., Narayan, P. and Padley, R. J.: The efficacy of terazosin, finasteride, or both in benign prostatic hyperplasia. Veterans Affairs Cooperative Studies Benign Prostatic Hyperplasia Study Group [see comments]. N. Engl. J. Med., 335: 533, 1996.
    • (1996) N. Engl. J. Med. , vol.335 , pp. 533
    • Lepor, H.1    Williford, W.O.2    Barry, M.J.3    Brawer, M.K.4    Dixon, C.M.5    Gormley, G.6    Haakenson, C.7    Machi, M.8    Narayan, P.9    Padley, R.J.10
  • 27
    • 0029939081 scopus 로고    scopus 로고
    • The Hytrin Community Assessment Trial study: A one-year study of terazosin versus placebo in the treatment of men with symptomatic benign prostatic hyperplasia. HYCAT Investigator Group
    • Roehrborn, C. G., Oesterling, J. E., Auerbach, S., Kaplan, S. A., Lloyd, L. K., Milam, D. E. and Padley, R. J.: The Hytrin Community Assessment Trial study: a one-year study of terazosin versus placebo in the treatment of men with symptomatic benign prostatic hyperplasia. HYCAT Investigator Group. Urology, 47: 159, 1996.
    • (1996) Urology , vol.47 , pp. 159
    • Roehrborn, C.G.1    Oesterling, J.E.2    Auerbach, S.3    Kaplan, S.A.4    Lloyd, L.K.5    Milam, D.E.6    Padley, R.J.7
  • 28
    • 0027489138 scopus 로고
    • Efficacy and safety of the alpha-1 blocker doxazosin in the treatment of benign prostatic hyperplasia. Analysis of 5 studies. Doxazosin Study Groups
    • Janknegt, R. A. and Chapple, C. R.: Efficacy and safety of the alpha-1 blocker doxazosin in the treatment of benign prostatic hyperplasia. Analysis of 5 studies. Doxazosin Study Groups. Eur. Urol., 24: 319, 1993.
    • (1993) Eur. Urol. , vol.24 , pp. 319
    • Janknegt, R.A.1    Chapple, C.R.2
  • 29
    • 0030690163 scopus 로고    scopus 로고
    • Transforming growth factor betal transduced mouse prostate reconstitutions: II. Induction of apoptosis by doxazosin
    • Yang, G., Timme, T. L., Park, S. H., Wu, X., Wyllie, M. G. and Thompson, T. C.: Transforming growth factor betal transduced mouse prostate reconstitutions: II. Induction of apoptosis by doxazosin [see comments]. Prostate, 33: 157, 1997.
    • (1997) Prostate , vol.33 , pp. 157
    • Yang, G.1    Timme, T.L.2    Park, S.H.3    Wu, X.4    Wyllie, M.G.5    Thompson, T.C.6
  • 30
    • 0026841280 scopus 로고
    • Quantifying the smooth muscle content of the prostate using double-immunoenzymatic staining and color assisted image analysis
    • Shapiro, E., Hartanto, V. and Lepor, H.: Quantifying the smooth muscle content of the prostate using double-immunoenzymatic staining and color assisted image analysis. J. Urol., 147: 1167, 1992.
    • (1992) J. Urol. , vol.147 , pp. 1167
    • Shapiro, E.1    Hartanto, V.2    Lepor, H.3
  • 31
    • 0028268417 scopus 로고
    • Mesenchymal-epithelial interactions and transforming growth factor-beta expression during mouse prostate morphogenesis
    • Timme, T. L., Truong, L. D., Merz, V. W., Krebs, T., Kadmon, D., Flanders, K. C., Park, S. H. and Thompson, T. C.: Mesenchymal-epithelial interactions and transforming growth factor-beta expression during mouse prostate morphogenesis. Endocrinol., 134: 1039, 1994.
    • (1994) Endocrinol. , vol.134 , pp. 1039
    • Timme, T.L.1    Truong, L.D.2    Merz, V.W.3    Krebs, T.4    Kadmon, D.5    Flanders, K.C.6    Park, S.H.7    Thompson, T.C.8
  • 32
    • 0030670650 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 transduced mouse prostate reconstitutions: I. Induction of neuronal phenotypes
    • Yang, G., Timme, T. L., Park, S. H. and Thompson, T. C.: Transforming growth factor beta 1 transduced mouse prostate reconstitutions: I. Induction of neuronal phenotypes [see comments]. Prostate, 33: 151, 1997.
    • (1997) Prostate , vol.33 , pp. 151
    • Yang, G.1    Timme, T.L.2    Park, S.H.3    Thompson, T.C.4
  • 34
    • 0026636723 scopus 로고
    • Transforming growth factor beta has neurotrophic actions on sensory neurons in vitro and is synergistic with nerve growth factor
    • Chalazonitis, A., Kalberg, J., Twardzik, D. R., Morrison, R. S. and Kessler, J. A.: Transforming growth factor beta has neurotrophic actions on sensory neurons in vitro and is synergistic with nerve growth factor. Dev. Biol., 152: 121, 1992.
    • (1992) Dev. Biol. , vol.152 , pp. 121
    • Chalazonitis, A.1    Kalberg, J.2    Twardzik, D.R.3    Morrison, R.S.4    Kessler, J.A.5
  • 35
    • 0025284127 scopus 로고
    • Evolving patterns of tissue composition in benign prostatic hyperplasia as a function of specimen size
    • Price, H., McNeal, J. E. and Stamey, T. A.: Evolving patterns of tissue composition in benign prostatic hyperplasia as a function of specimen size. Hum. Pathol., 21: 578, 1990.
    • (1990) Hum. Pathol. , vol.21 , pp. 578
    • Price, H.1    McNeal, J.E.2    Stamey, T.A.3
  • 36
    • 0006075228 scopus 로고    scopus 로고
    • The effect of finasteride on the risk of acute urinary retention and the need for surgical treatment among men with benign prostatic hyperplasia. Finasteride Long-Term Efficacy and Safety Study Group
    • McConnell, J. D., Bruskewitz, R., Walsh, P., Andriole, G., Lieber, M., Holtgrewe, H. L., Albertsen, P., Roehrborn, C. G., Nickel, J. C., Wang, D. Z., Taylor, A. M. and Waldstreicher, J.: The effect of finasteride on the risk of acute urinary retention and the need for surgical treatment among men with benign prostatic hyperplasia. Finasteride Long-Term Efficacy and Safety Study Group [see comments]. N. Engl. J. Med., 338: 557, 1998.
    • (1998) N. Engl. J. Med. , vol.338 , pp. 557
    • McConnell, J.D.1    Bruskewitz, R.2    Walsh, P.3    Andriole, G.4    Lieber, M.5    Holtgrewe, H.L.6    Albertsen, P.7    Roehrborn, C.G.8    Nickel, J.C.9    Wang, D.Z.10    Taylor, A.M.11    Waldstreicher, J.12


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.