Hepatic hydroxylation of bile acids and chronic liver diseases: Do transporters play a mechanistic role?

Journal of Gastroenterology and Hepatology (Australia)

Volumn 16, Issue 12, 2001, Pages 1313-1315

  Tazuma, Susumu ^a   Chayama, Kazuaki ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CARRIER PROTEIN; CHENODEOXYCHOLIC ACID; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; TAUROCHOLIC ACID; URSODEOXYCHOLIC ACID;

BILE ACID BLOOD LEVEL; BILE ACID METABOLISM; BILE ACID SYNTHESIS; CHOLESTASIS; CHRONIC LIVER DISEASE; DETOXIFICATION; DRUG EFFICACY; DRUG METABOLISM; DRUG TRANSFORMATION; DRUG URINE LEVEL; EDITORIAL; GENE MUTATION; HUMAN; HYDROXYLATION; LIPID TRANSPORT; LIVER INJURY; LIVER METABOLISM; PREDICTION; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; URINARY EXCRETION;

EID: 0035702445     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1746.2001.02637.x     Document Type: Editorial

References (11)

1. Differences in the efficacy of ursodeoxycholic acid and bile acid metabolism between viral liver diseases and primary biliary cirrhosis
2. A paucity of unusual trihydroxy bile acids in the urine of patients with severe liver diseases
3. Formation of unusual trihydroxy bile acids in humans: Mechanism for decreasing hydrophobicity and toxic potential of bile acids?
4. Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport
5. Molecular aspects of hepatobiliary transport
6. Molecular pathogenesis of cholestasis
7. Molecular regulation of hepatocellular transport systems in cholestasis
8. Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases
9. Hepatic transport of bile salts
10. Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats
11. Increased expression of multidrug resistance-associated protein 1 (mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats