Tyrosine phosphorylation of picot and its translocation to the nucleus in response of human t cells to oxidative stress

Advances in Experimental Medicine and Biology

Volumn 495, Issue , 2001, Pages 41-45

  Babichev, Yael ^a   Isakov, Noah ^a  

^a Cancer Research Center   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; GENE PRODUCT; HYDROGEN PEROXIDE; PROTEIN KINASE C; PROTEIN PICOT; REACTIVE OXYGEN METABOLITE; T LYMPHOCYTE RECEPTOR; TYROSINE; UNCLASSIFIED DRUG;

CELL STIMULATION; CELLULAR DISTRIBUTION; CONFERENCE PAPER; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0035701961     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-0685-0_6     Document Type: Conference Paper

References (12)

1. Molecular cloning and characterization of PKC θ, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells
2. Protein kinase C-θ (PKCθ) distribution analysis in hematopoietic cells. Proliferating T cells exhibit high proportions of PKCθ in the particulate fraction
3. Protein kinase C-θ: A new essential superstar on the T cell stage
4. Tree-dimensional segragation of supramolecular activation clusters in T cells
5. PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes
6. Anchoring proteins for protein kinase C: A means for isozyme selectivity
7. Direct interaction between protein kinase C θ (PKCθ) and 14-3-3τ in T cells: 14-3-3 Overexpression results in inhibition of PKC θ translocation and function
8. The HIV Nef protein associates with protein kinase C θ
9. Direct interaction in T-cells between θPKC and the tyrosine kinase p59fyn
10. Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-κB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin-homology domain
11. PICOT-HD, a highly conserved protein domain that is often associated with thioredoxin and glutaredoxin modules
12. Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-alpha