Phage display of epitopes from HIV-1 elicits strong cytolytic responses in vitro and in vivo

Advances in Experimental Medicine and Biology

Volumn 495, Issue , 2001, Pages 291-298

  Guardiola, John ^a   De Berardinis, Piergiuseppe ^b   Sartorius, Rossella ^b   Fanutti, Cristina ^c   Perham, Richard N ^c   Del Pozzo, Giovanna ^a  

^a INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^b INSTITUTE OF PROTEIN BIOCHEMISTRY   (Italy)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOPHAGE DNA; EPITOPE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; RNA DIRECTED DNA POLYMERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG EFFICACY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTOTOXICITY; MOUSE; NONHUMAN; NORMAL HUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

AIDS VACCINES; ANIMALS; BACTERIOPHAGES; CYTOTOXICITY, IMMUNOLOGIC; EPITOPES; HIV ANTIGENS; HIV-1; HLA-A2 ANTIGEN; HUMANS; MICE; MICE, TRANSGENIC; PEPTIDE LIBRARY; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, HELPER-INDUCER;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0035699658     PISSN: 00652598     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-1-4615-0685-0_40     Document Type: Article

References (20)

1. Towards development of T-cell vaccines
2. The minimal number of class II MHC-antigen complexes needed for T cell activation
3. Kinetics of generation and persistence on membrane class II molecules of a viral peptide expressed on foreign and self proteins
4. Multiple display of foreign peptides on a filamentous bacteriophage. Peptides from Plasmodium falciparum circumsporozoite protein as antigens
5. Design of specific immunogens using filamentous phage as the carrier
6. New vectors for peptide display on the surface of filamentous bacteriophage
7. Simultaneous display of different peptides on the surface of filamentous bacteriophage
8. Structural mimicry and enhanced immunogenicity of peptide epitopes displayed onfilamentous bacteriophage. The V3 loop of HIV-1 gp120
9. NMR structure of the principal neutralizing determinant of HIV-1 displayed in filamentous bacteriophage coat protein
10. Recognition of HIV-derived B and T cell epitopes displayed on filamentous phages
11. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
12. Antigen organization regulates cluster formation and induction of cytotoxic T lymphocytes by helper T cell subsets
13. Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors
14. Helper activity is required for the in vivo generation of cytotoxic T lymphocytes
15. Antigenicity of HIV-derived T helper determinants in the context of carrier recombinant proteins: Effect on T helper cell repertoire selection
16. Cytotoxic T-lymphocyte responses to HIV-1 reverse transcriptase
17. HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice
18. Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class 1 major histocompatibility complex
19. High resolution structures of HIV-1 RT from four RT-inhibitor complexes
20. Immunodominant epitope regions of HIV-1 reverse transcriptase: Correlations with HIV-1+ serum IgG inhibitory to polymerase activity and with disease progression