Glucose-dependent and glucose-sensitizing insulinotropic effect of nateglinide: Comparison to sulfonylureas and repaglinide

International Journal of Experimental Diabetes Research

Volumn 2, Issue 1, 2001, Pages 63-72

  Hu, Shiling ^a   Wang, Shuya ^a   Dunning, Beth E ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Glucose sensitivity; Glucose stimulated insulin secretion; Nateglinide; Rat pancreatic islets; Static incubation

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIDIABETIC AGENT; GLIBENCLAMIDE; GLUCOSE; INSULIN; NATEGLINIDE; PHENYLALANINE DERIVATIVE; POTASSIUM CHANNEL; REPAGLINIDE; SULFONYLUREA DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; HYPOGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN LIKE ACTIVITY; INSULIN RELEASE; ISOLATED PANCREAS ISLET; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

EID: 0035695566     PISSN: 15604284     EISSN: None     Source Type: Journal    
DOI: 10.1155/EDR.2001.63     Document Type: Article

References (35)

1. + channels in pancreatic β-cells
2. The insulin factory: A tour of the plant surroundings and a visit to the assembly line
3. The sulphonylurea receptor may be an ATP-sensitive potassium channel
4. + channels in an insulin-secreting cell line
5. + channels and stimulation of insulin secretion by the sulfonylurea, glimepiride, in relation to its membrane binding in pancreatic islets
6. Effects of the hypoglycemic drugs repaglinide and glibenclamide on ATP-sensitive potassium-channels and cytosolic calcium levels in β TC3 cells and rat pancreatic beta cells
7. Stimulation of insulin release by non-sulfonylurea hypoglycemic agents: The meglitiide family
8. Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes
9. A new hypoglycemic agent, A-4166, inhibits ATP-sensitive potassium channels in rat pancreatic β-cells
10. Insulin secretion from isolated rat islets induced by the novel hypoglycemic agent A-4 166, a derivative of D-phenylalanine
11. Hypoglycemic effects of the novel antidiabetic agent repaglinide in rat and dogs
12. The metabolic advantages of a rapid onset/short acting insulin secretagogue on prandial glucose excursions
13. Stimulating activity of A-4166 on insulin release in in situ hamster pancreatic perfusion
14. Hypoglycemic and insulinotropic effects of a novel oral antidiabetic agent, (-)-N-(trans-4-isopropylcyclohexane-carbonyl)-D-Phenylalanine (A-4 166)
15. ATP channel in β-cells:comparison to glyburide and repaglinide
16. Method for the isolation of intact islets of Langerhans from the rat pancreas
17. Scintillation proximity assay: A versatile high-throughout screening technology
18. The effect of mannoheptulose on the phosphorylation of glucose and the secretion of insulin by islets of Langerhans
19. Effects of iodoacetate, mannoheptulose and 3-O-methyl glucose on the secretory function and metabolism of isolated pancreatic islets
20. Effect of low temperatures on glucose-induced insulin secretion and glucose metabolism in isolated pancreatic islets of the rat
21. Insulin biosynthesis and secretion in vitro. Chapter II
22. Ay-4166 increases the sensitivity of insulin secretion to glucose in isolated perfused rat pancreas
23. The stimulus-secretion coupling of glucose-induced insulin release-XVII. Effects of sulfonylureas and diazoxide on insular biosynthetic activity
24. Repaglinide preserves nutrient-stimulated biosynthetic activity in rat pancreatic islets
25. Glibenclamide-associated hypoglycemia: A report on 57 cases
26. SUs and hypoglycemia
27. Drug-induced hypoglycemia
28. Stimulation of insulin release by D-glucose in depolarized pancreatic islets
29. Somatostatin and insulin secretion due to common mechanisms by a new hypoglycemic agent, A-4166, in perfused rat pancreas
30. Effect of sulphonylurea on glucose-stimulated insulin secretion in healthy and non-insulin dependent diabetic subjects: A dose-response study
31. Effect of glibenclamide on insulin release at moderate and high blood glucose levels in normal man
32. Effect of acute administration of gliclazide on the glucose sensitivity of pancreatic B-cells in healthy subjects
33. Studies on the N-[(trans-4-isopropylcyclohexyl)-carbonyl]-D-phenylalanine (A-4166) receptor in HIT T-15 cells
34. Internalization of glimepiride in the pancreatic B-cell
35. Fate of 3H- and 14C-labelled A-4166 in pancreatic islets