Fate of3H- And14C-labelled A-4166 in pancreatic islets

Acta Diabetologica

Volumn 33, Issue 4, 1996, Pages 298-300

  Malaisse Lagae, F ^a   Malaisse, W J ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Meglitinide analogue; Pancreatic islets

Indexed keywords

ANTIDIABETIC AGENT; CARBON; CYCLOHEXANE DERIVATIVE; DIAGNOSTIC AGENT; DRUG DERIVATIVE; NATEGLINIDE; PHENYLALANINE; TRITIUM; CARBON 14; GLUCOSE; SULFONYLUREA DERIVATIVE;

ANIMAL; ARTICLE; AUTORADIOGRAPHY; CELL CULTURE; CYTOLOGY; FEMALE; METABOLISM; PANCREAS ISLET; RAT; ULTRASTRUCTURE; WISTAR RAT; ANIMAL TISSUE; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG RECEPTOR BINDING; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; AUTORADIOGRAPHY; CARBON RADIOISOTOPES; CELLS, CULTURED; CYCLOHEXANES; FEMALE; HYPOGLYCEMIC AGENTS; ISLETS OF LANGERHANS; PHENYLALANINE; RATS; RATS, WISTAR; TRITIUM;

EID: 0030299892     PISSN: 09405429     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00571569     Document Type: Article

References (20)

1. Malaisse WJ, Stimulation of insulin release by non-sulfonylurea hypoglycemic agents: the meglitinide family. Horm Metab Res 27:263-266, 1995
2. Malaisse WJ, Sato F, Insulinotropic action of sodium (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate. I. Secretory and cationic aspects. Gen Pharmacol 26:1313-1318, 1995
3. Lins L, Brasseur R, Malaisse WJ, Conformational analysis of non-sulfonylurea hypoglycemic agents of the meglitinide family. Biochem Pharmacol 50:1879-1884, 1995
4. Bakkali Nadi A, Malaisse-Lagae F, Malaisse WJ, Insulinotropic action of meglitinide analogs: concentration-response relationship and nutrient dependency. Diabetes Res 27:81-87, 1994
5. 45Ca uptake by subcellular fractions prepared from rat pancreatic islets. Med Sci Res 23:843-844, 1995
6. Viñambres C, Garcia-Martinez JA, Villanueva-Peñacarrillo ML, Valverde I, Malaisse WJ, Preservation of nutrient-stimulated biosynthetic activity in pancreatic islets exposed to a meglitinide analogue. Med Sci Res 23:779-780, 1995
7. Bakkali Nadi A, Zhang T-M, Malaisse WJ, Effects of the methyl esters of pyruvate. succinate and glutamate on the secretory response to meglitinide analogues in rat pancreatic islets. Pharmacol Res 33:191-194, 1996
8. + concentrations. Pharmacol Res 32:111-114, 1995
9. Malaisse-Lagae F, Malaisse WJ, Insulin release by pancreatic islets. In: Larner R, Pohl SL (eds) Methods in diabetes research. Wiley, New York, pp 147-152, 1984
10. 45calcium by isolated islets of Langerhans. Endocrinology 88:72-89, 1971
11. Marynissen G, Smets G, Klöppel G, Gerlache L, Malaisse WJ, Internalization of glimepiride and glibenclamide in the pancreatic B-cell. Acta Diabetol 29:113-114, 1992
12. Sehlin J, Evidence for specific binding of tolbutamide to the plasma membrane of the pancreatic B-cells. Acta Diabetol Lat 10:1052-1060, 1973
13. 3H-glibenclamide in pancreatic islet cells. Diabetologia 29:259-261, 1986
14. Malaisse WJ, Lebrun P, Iterative stimulation of pancreatic islets by glipizide. Pharmacology 46:43-49, 1993
15. 2+ influx into the pancreatic B-cell. Diabetes 31:1010-1015, 1982
16. Lebrun P, Malaisse WJ, Cationic and secretory effects of glimepiride and glibenclamide in perifused rat islets. Pharmacol Toxicol 70:357-360, 1992
17. Malaisse WJ, Lebrun P, Sener A, Modulation of the insulinotropic action of glibenclamide and glimepiride by nutrient secretagogues in pancreatic islets from normoglycemic and hyperglycemic rats. Biochem Pharmacol 45:1845-1849, 1993
18. Täljedal I-B. Uptake of glibornuride by microdissected pancreatic islets. Horm Res 5:211-216, 1974
19. Deleers M, Ruysschaert J-M, Malaisse WJ, Glucose induces membrane changes detected by fluorescence polarization in endocrine pancreatic cells. Biochem Biophys Res Commun 98:255-260, 1981
20. Deleers M, Malaisse WJ, Binding of hypoglycaemic sulfonylureas to an artificial phospholipid bilayer. Diabetologia 26:55-59, 1984