Studies on the N-[(trans-4-isopropylcyclohexyl)-carbonyl]-D-phenylalanine (A-4166) receptor in HIT T-15 cells. Displacement of [3H]glibenclamide

Biochemical Pharmacology

Volumn 52, Issue 3, 1996, Pages 407-411

  Fujita, Tomonobu ^a   Seto, Yoshiko ^a   Kondo, Nobuo ^b   Kato, Ryuichi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AJINOMOTO CO INC   (Japan)

Author keywords

A 4166; HIT; insulin secretion; receptor; sulfonylurea

Indexed keywords

DRUG RECEPTOR; GLIBENCLAMIDE; INSULIN; NATEGLINIDE; ORAL ANTIDIABETIC AGENT; POTASSIUM CHANNEL; RADIOLIGAND; RUBIDIUM 86; SULFONYLUREA DERIVATIVE; TOLBUTAMIDE;

ANIMAL CELL; ARTICLE; BINDING COMPETITION; BINDING SITE; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; INSULIN RELEASE; ION TRANSPORT; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RECEPTOR BINDING;

EID: 0030576668     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00242-0     Document Type: Article

References (22)

1. 1. Seto Y, Dan K and Fukuma Y, New hypoglycemic agents, N-(p-alkylbenzoyl)-D-phenylalanines. In: Best Approach to the Ideal Therapy of Diabetic Melutus (Eds. Y. Shigeta, H. Lebovitz, J. Gerich and W. Malaisse), pp. 371-374. Elsevier Science Publishers BV, Amsterdam, 1987.
2. 2. Shinkai H, Toi K, Kumashiro I, Seto Y, Fukuma M, Dan K and Toyoshima S, N-Acylphenylalanines and related compounds. A new class of oral hypoglycemic agents. J Med Chem 31: 2092-2097, 1988.
3. 3. Shinkai H, Nishikawa M, Sato Y, Toi K, Kumashiro I, Seto Y, Fukuma M, Dan K and Toyoshima S, N-(Cyclohexyl-carbonyl)-D-phenylalanines and related compounds. A new class of oral hypoglycemic agents. 2. J Med Chem 32: 1436-1441, 1989.
4. 4. Hirose H, Maruyama H, Ito K, Seto Y, Kido K, Koyama K, Dan K, Saruta T and Kato R, Effects of N-[trans-4-isopropylcyclohexyl)-carbonyl]-D-phenylalanine (A-4166) on insulin and glucagon secretion in isolated perfused rat pancreas. Pharmacology 48: 205-210, 1994.
5. 5. Hirose H, Maruyama H, Seto Y, Ito K, Fujita T, Dan K, Kanda N, Saruta T and Kato R, Effects of D-phenylalanine-derivative hypoglycemic agent A-4166 on pancreatic α- and β-cells: Comparative study with glibenclamide. Pharmacology 50: 175-181, 1995.
6. 6. Sato Y, Nishikawa M, Shinkai H and Sukegawa E, Possibility of ideal blood glucose control by a new oral hypoglycemic agent, N-[(trans-4-isopropylcyclohexyl)-carbonyl]-D-phenylalanine (A-4166), and its stimulatory effect on insulin secretion in animals. Diabetes Res Clin Pract 12: 53-59, 1991.
7. 2+ influx. Endocrinology 134: 1395-1400, 1994.
8. 8. Ashcroft SJH and Ashcroft FM, The sulfonylurea receptor. Biochim Biophys Acta 1175: 45-59, 1992.
9. 9. Boyd AE III, Aguilar-Bryan L, Bryan J, Kunze DL, Moss L, Nelson DA, Rajan AS, Raef H, Xiang HD and Yaney GC, Sulfonylurea signal transduction. Recent Prog Horm Res 47: 299-316, 1991.
10. 10. Seto Y, Fujita H, Dan K, Fujita T and Kato R, Stimulating activity of A-4166 on insulin release in in situ hamster pancreatic perfusion. Pharmacology 51: 245-253, 1995.
11. 11. Gaines KL, Hamilton S and Boyd AE III, Characterization of the sulfonylurea receptor on beta cell membranes. J Biol Chem 263: 2589-2592, 1988.
12. + channel in insulin-secreting cells. J Biol Chem 262: 15840-15844, 1987.
13. 13. Akiyoshi M, Kakei M, Nakazaki M and Tanaka H, A new hypoglycemic agent, A-4166, inhibits ATP-sensitive potassium channels in rat pancreatic β-cells. Am J Physiol 268: E185-E193, 1995.
14. 14. Niki I, Kelly RP, Ashcroft SJH and Ashcroft FM, ATP-sensitive K-channels in HIT T15 β-cells studied by patch-clamp methods, 86Rb efflux and glibenclamide binding. Pflügers Arch 415: 47-55, 1989.
15. 15. Panten U, Burgfeld J, Goerke F, Rennicke M, Schwanstecher M, Wallasch A, Zünkler BJ and Lenzen S, Control of insulin secretion by sulfonylureas, meglitinide and diazoxide in relation to their binding to the sulfonylurea receptor in pancreatic islets. Biochem Pharmacol 38: 1217-1229, 1989.
16. 16. Ashcroft FM, Kerr AJ, Gibson JS and Williams BA, Amantadine and sparteine inhibit ATP-regulated K-currents in the insulin-secreting beta-cell line, HIT-T15. Br J Pharmacol 104: 579-584, 1991.
17. 17. Garrino MG, Schmeer W, Nenquin M, Meissner HP and Henquin JC, Mechanism of the stimulation of insulin release in vitro by HB 699, a benzoic acid derivative similar to the non-sulphonylurea moiety of glibenclamide. Diabetologia 28: 697-703, 1985.
18. 18. Garrino MG and Henquin JC, Highly potent and stereoselective effects of the benzoic acid derivative AZ-DF 265 on pancreatic β-cells. Br J Pharmacol 93: 61-68, 1988.
19. + channels in pancreatic β-cells by nonsulfonylurea drug linogliride. Diabetes 40: 885-892, 1991.
20. 20. Ronner P, Hang TL, Kraebber MJ and Higgins TJ, Effect of the hypoglycaemic drug (-)-AZ-DF-265 on ATP-sensitive potassium channels in rat pancreatic β-cells. Br J Pharmacol 106: 250-255, 1992.
21. + channel. Eur J Pharmacol 198: 101-104, 1991.
22. 22. Sturgess NC, Kozlowski RZ, Carrington CA, Hales CN and Ashford MLJ, Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line. Br J Pharmacol 95: 83-94, 1988.