New therapeutic approaches for diabetes

Medicinal Chemistry Research

Volumn 10, Issue 7-8, 2001, Pages 480-492

  McCormack, James G ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

6 [[2 [[2 (2 CYANO 1 PYRROLIDINYL) 2 OXOETHYL]AMINO]ETHYL]AMINO]NICOTINONITRILE; GLUCAGON LIKE PEPTIDE 1; INSULIN ASPART; INSULIN DERIVATIVE; INSULIN DETEMIR; METFORMIN; REPAGLINIDE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD GLUCOSE MONITORING; DIABETES CONTROL; DIABETES MELLITUS; DRUG EFFECT; DYSLIPIDEMIA; GLUCONEOGENESIS; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; INSULIN TREATMENT; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PANCREAS ISLET BETA CELL; PANCREAS ISLET DISEASE; TREATMENT OUTCOME; TREATMENT PLANNING;

EID: 0035695501     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. The rising global burden of diabetes: Estimates and projections to the year 2010
2. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes
3. Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes
4. Insulin analogues and their potential in the management of diabetes mellitus
5. Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use
6. Insulin aspart: A novel rapid-acting human insulin analogue
7. Soluble, fatty acid acylated insulins bind to albumin and show protracted action in pigs
8. Islet transplantation in seven patients with type 1 diabates mellitus using a glucocorticoid-free immunosuppressive regimen
9. Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue
10. Glucose-dependent insulin release from genetically engineered K cells
11. Poor glycaemic control in type 2 diabetes: A conspiracy of disease, suboptimal therapy and attitude
12. Efficacy of inhaled insulin in type 1 diabetes mellitus: A randomised proof-of-concept study
13. Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes
14. PPAR-γ agonists: Therapeutic role in diabetes, inflammation and cancer
15. Metformin: A review of its metabolic effects
16. Protein tyrosine phosphatases (PTPs) as drug targets: Inhibitors of PTP-1B for the treatment of diabetes
17. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
18. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein tyrosine phosphatase 1B-deficient mice
19. The lipid phosphatase SHIP2 controls insulin sensitivity
20. The hormone resistin links obesity to diabetes
21. Pharmacological approaches to inhibit endogenous glucose production as a means of anti-diabetic therapy
22. Evidence for a major role for glucagon in regulation of plasma glucose in conscious, non-diabetic, and alloxan-induced diabetic rabbits
23. The human liver glycogen phosphorylase inhibitor CP-320626 shows sustained glucose lowering on multiple dosing in diabetic ob/ob mice
24. Evidence that metformin exerts its antidiabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
25. A review of clinical experience with the prandial glucose regaultor, repaglinide, in the treatment of type 2 diabetes
26. Diazoxide improves insulin sensitivity in Zucker obese rats
27. Glucagon-like peptide 1 (GLP-1): An intestinal hormone, signalling nutritional abundance, with unusual therapeutic potential
28. Potent derivates of glucagon-like peptide-1 with pharmacokinetic properties suitable for one daily administration
29. Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes
30. The human obesity gene map
31. Mitochondrial uncoupling proteins
32. What if Minkowski had been ageusic? An alternative angle on diabetes
33. Effects of prolonged acipimox treatment on glucose and lipid metabolismand on insulin sensitivity in patients with non-insulin dependent diabetes mellitus