Evaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome p450 enzymes

Xenobiotica

Volumn 31, Issue 12, 2001, Pages 861-878

  Renwick, A B ^a   Lavignette, G ^a   Worboys, P D ^a   Williams, B ^a   Surry, D ^a   Lewis, D F V ^a   Price, R J ^a   Lake, B G ^a   Evans, D C ^a  

^a TNO BIBRA International Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA CYANOPREGNENOLONE; 7 BENZYLOXY 4 TRIFLUOROMETHYLCOUMARIN; BETA NAPHTHOFLAVONE; COUMARIN DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 3A; DEXAMETHASONE; ISONIAZID; METHYLCLOFENAPATE; PHENOBARBITAL; QUINOLINOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; LIVER; LIVER MICROSOME; MALE; METABOLISM; NONHUMAN; RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; COUMARINS; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; FLUORESCENT DYES; ISOENZYMES; MALE; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; PHENOBARBITAL; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; SUBSTRATE SPECIFICITY;

ANIMALIA; INSECTA; STAPHYLOCOCCUS PHAGE 3A; UNIDENTIFIED BACULOVIRUS;

EID: 0035692202     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/00498250110074063     Document Type: Article

References (41)

1. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochromes P-450
2. Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human liver microsomes
3. A highly sensitive tool for the assay of cytochrome P450 enzyme activity in rat, dog and man. Direct fluorescence monitoring of the deethylation of 7-ethoxy-4-trifluoromethylcoumarin
4. Description of a 96-well plate assay to measure cytochrome P4503A inhibition in human liver microsomes using a selective fluorescent probe
5. In vitro assessment of human cytochrome P450
6. Induction of microsomal cytochrome P-450 enzymes: The first Bernard B Brodie lecture at Pennsylvania State University
7. Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450
8. High throughput screening for inhibition of cytochrome P450 metabolism
9. A direct, highly sensitive assay for cytochrome P-450 catalyzed O-deethylation using a novel coumarin analog
10. A microassay for measuring cytochrome P450IA1 and P450IIB1 activities in intact human and rat hepatocytes cultured on 96-well plates
11. Isolation, culture and use of human hepatocytes in drug research
12. Evidence for and possible mechanisms of non-genotoxic carcinogenesis in rodent liver
13. Peroxisome proliferation in primary cultures of rat hepatocytes
14. Effect of treatment with pyrazine and some derivatives on cytochrome P450 and some enzyme activities in rat liver
15. Preparation and characterisation of microsomal fractions for studies of xenobiotic metabolism
16. Mechanisms of hepatocarcinogenicity of peroxisome-proliferating drugs and chemicals
17. In vitro methods
18. The CYP4 family
19. Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver
20. Inhibition and induction of cytochrome P450 and the clinical implications
21. Protein measurement with the Folin phenol reagent
22. Induction of hepatic cytochrome P-450 mediated alkoxyresorufin O-dealkylase activities in different species by prototype P-450 inducers
23. The CYP3 family
24. 7-Alkoxyquinolines: New fluorescent substrates for cytochrome P450 monooxygenases
25. P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
26. Methoxyresorufin and benzyloxyresorufin: Substrates preferentially metabolised by cytochromes P4501A2 and 2B, respectively, in the rat and mouse
27. The CYP2B subfamily
28. Induction of alkoxyresorufin O-dealkylases, epoxide hydrolase, and liver weight gain: Correlation with tumor-promoting potential in a series of barbiturates
29. Enzyme induction in the cytochrome P-450 system
30. Biotransformation of xenobiotics
31. Inhibition and induction of human cytochrome P450 (CYP) enzymes
32. CYP isoform induction screening in 96-well plates: Use of 7-benzyloxy-4-trifluoromethylcoumarin as a substrate for studies with rat hepatocytes
33. Comparison of ethanol and imidazole pretreatments on hepatic monooxygenase activities in the rat
34. Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethylcoumarin by human hepatic CYP isoforms: Evidence for selectivity towards CYP3A4
35. Metabolism of 7-benzyloxy-4-trifluoromethylcoumarin by human hepatic cytochrome P450 isoforms
36. Integrated cytochrome P450 reaction phenotyping. Attempting to bridge the gap between cDNA-expressed cytochromes P450 and native human liver microsomes
37. Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P450
38. Clinically important drug-drug interactions: Role of cytochrome P450 enzymes
39. A continuous fluorimetric assay for P-450-dependent mixed function oxidases using 3-cyano-7-ethoxycoumarin
40. Phenobarbital mechanistic data and risk assessment: Enzyme induction, enhanced cell proliferation, and tumor promotion
41. In vitro methods for assessing human hepatic drug metabolism: Their use in drug development