snRNP protein expression enhances the formation of Cajal bodies containing p80-coilin and SMN

Journal of Cell Science

Volumn 114, Issue 24, 2001, Pages 4407-4419

  Sleeman, Judith E ^a   Ajuh, Paul ^a   Lamond, Angus I ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Cajal bodies; Leptomycin B; p80 coilin; SMN; snRNPs

Indexed keywords

LEPTOMYCIN B; PROTEIN; SMALL NUCLEAR RIBONUCLEOPROTEIN;

ANALYSIS; ARTICLE; CELL LINE; CELL NUCLEUS; CELL NUCLEUS INCLUSION BODY; COILED BODY; CONTROLLED STUDY; FLUORESCENCE; GENE OVEREXPRESSION; HELA CELL; HETEROKARYON; HUMAN; HUMAN CELL; MOTONEURON; NUCLEAR IMPORT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLICEOSOME;

EID: 0035691790     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.114.24.4407     Document Type: Article

References (52)

1. Human autoantibody to a novel protein of the nuclear coiled body: Immunological characterization and cDNA cloning of p80-coilin
2. Molecular analysis of the coiled body
3. The movement of coiled bodies visualized in living plant cells by the green fluorescent protein
4. Histone genes are located at the sphere loci of Xenopus lampbrush chromosomes
5. Assembly Of snRNP-containing coiled bodies is regulated in interphase and mitosis - Evidence that the coiled body is a kinetic nuclear structure
6. The spinal muscular atrophy disease gene product, SMN: A link between snRNP biogenesis and the Cajal (coiled) body
7. Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems
8. Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli
9. Nucleo-cytoplasmic transport of U snRNPs: Definition of a nuclear location signal in the Sm core domain that binds a transport receptor independently of the m3G cap
10. The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis
11. CRM1 is an export receptor for leucine-rich nuclear export signals
12. Association of snRNA genes with coiled bodies is mediated by nascent snRNA transcripts
13. Cajal bodies: The first 100 years
14. Assembly of the nuclear transcription and processing machinery: Cajal bodies (coiled bodies) and transcriptosomes
15. Human genes encoding U3 snRNA associate with coiled bodies in interphase cells and are clustered on chromosome 17p11.2 in a complex inverted repeat structure
16. Mapping of B cell epitopes on small nuclear ribonucleoproteins that react with human autoantibodies as well as with experimentally-induced mouse monoclonal antibodies
17. The trimethylguanosine cap structure of U1 snRNA is a component of a bipartite nuclear targeting signal
18. snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions
19. Structure and assembly of the spliceosomal small nuclear ribonucleoprotein particles
20. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1
21. An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs
22. cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: Evidence for a direct D1-D2 interaction
23. Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythmatosus
24. A Novel Nuclear-Structure Containing the Survival Of Motor-Neurons Protein
25. The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins
26. Structure of spliceosomal snRNPs and their role in pre-mRNA splicing
27. Inhibition of protein dephosphorylation results in the accumulation of splicing snRNPs and coiled bodies within the nucleolus
28. Nuclear bodies: Multifaceted subdomains of the interchromatin space
29. Coiled bodies and gems: Janus or gemini?
30. Nucleoplasmic organization of small nuclear ribonucleoproteins in cultured human cells
31. Cap trimethylation of snRNA is cytoplasmic and dependent on U snRNP protein binding
32. RNA-protein interactions in the splicing snRNPs
33. Role of the box C/D motif in localization of small nucleolar RNAs to coiled bodies and nucleoli
34. A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing
35. SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins
36. The structure of mammalian small nuclear ribonucleoproteins. Identification of multiple protein components reactive with anti- (U1) ribonucleoprotein and anti-Sm autoantibodies
37. High mobility of proteins in the mammalian cell nucleus
38. In vivo analysis of Cajal body movement, separation, and joining in live human cells
39. The snRNP core assembly pathway: Identification of stable core protein heteromeric complexes and an snRNP subcore particle in vitro
40. Nuclear neighbours: The spatial and functional organization of genes and nuclear domains
41. Coiled bodies are predisposed to a spatial association with genes that contain snoRNA sequences in their introns
42. Nuclear domains enriched in RNA 3′-processing factors associate with coiled bodies and histone genes in a cell cycle-dependent manner
43. Dynamic interactions between splicing snRNPs, coiled bodies and nucleoli revealed using snRNP protein fusions to the green fluorescent protein
44. Newly assembled snRNPs associate with coiled bodies before speckles, suggesting a nuclear snRNP maturation pathway
45. U2 and U1 snRNA gene loci associate with coiled bodies
46. Mutational analysis of fibrillarin and its mobility in living human cells
47. Differences in snRNP localization between transformed and nontransformed cells
48. Fusion of somatic cells
49. Modification of U6 spliceosomal RNA is guided by other small RNAs
50. Nuclear export receptors: From importin to exportin
51. The relationship between SMN, the spinal muscular atrophy protein, and nuclear coiled bodies in differentiated tissues and cultured cells
52. Modifications of U2 snRNA are required for snRNP assembly and pre-mRNA splicing