Induction of hepatic and presystemic metabolism of antipyrine in the mice: Rifampicin versus rifabutin

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 26, Issue 4, 2001, Pages 209-213

  Liu, Xiao G ^a   Narang, Prem K ^b   Li, Ronald C ^c  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b PFIZER INC   (United States)

^c Prince of Wales Hospital   (Hong Kong)

Author keywords

Enzyme induction; GI tract; Liver; P450; Rifabutin; Rifampicin

Indexed keywords

CYTOCHROME P450; PHENAZONE; RIFABUTIN; RIFAMPICIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG EXPOSURE; DRUG METABOLISM; ENZYME INDUCTION; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; PROTEIN CONTENT;

ADMINISTRATION, ORAL; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIPYRINE; BIOLOGICAL AVAILABILITY; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; ENZYME INHIBITORS; INTESTINE, SMALL; MALE; MICE; MICE, INBRED ICR; MICROSOMES, LIVER; RIFABUTIN; RIFAMPIN;

EID: 0035686140     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03226373     Document Type: Article

References (19)

1. Clinical pharmacokinetics of rifabutin
2. Induction and autoinduction properties of rifamycin derivatives: A review of animal and human studies
3. Update on rifampin drug interactions, III
4. Inducing properties of rifabutin, and effects on the pharmacokinetics and metabolism of concomitant drugs
5. Pharmacokinetics of oral and intravenous rifampin during chronic administration
6. A model based assessment of redistribution dependent elimination and bioavailability of rifabutin
7. Assessment of presystemic factors on the oral bioavailability of rifampicin following multiple dosing
8. Assay of antipyrine and its primary metabolites in plasma, saliva and urine by high-performance liquid chromatography and some preliminary results in man
9. Noncompartmental analysis based on statistical moment theory
10. Microsomal enzymes involved in toxicology analysis and separation
11. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
12. Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery
13. P-glycoprotein: A defense mechanism limiting oral bioavailability and CNS accumulation of drugs
14. The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin
15. Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: A new type of drug/drug interaction
16. Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin
17. Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction
18. Effects of rifampin on tacrolimus pharmacokinetics in healthy volunteers
19. The nifedipine-rifampin interaction: Evidence for induction of gut wall metabolism