Pharmacokinetics of E-6087, a new anti-inflammatory agent, in rats and dogs

Biopharmaceutics and Drug Disposition

Volumn 22, Issue 6, 2001, Pages 231-242

  Reinoso, Raquel F ^a   Farrán, Ramón ^a   Moragón, Trinidad ^a   García Soret, Antonio ^a   Martínez, Lluis ^a  

^a Laboratorios Dr Esteve SA   (Spain)

Author keywords

Anti inflammatory agents; Cyclooxygenase 2; Dog; Pharmacokinetics; Rat

Indexed keywords

4 [5 (2,4 DILFLUOROPHENYL) 4,5 DIHYDRO 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2 INHIBITOR; DRUG METABOLITE; E 6087; E 6132; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DISTRIBUTION VOLUME; DOG; DOSE RESPONSE; DRUG ABSORPTION; DRUG ACTIVITY; DRUG ADMINISTRATION ROUTE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXPOSURE; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG STRUCTURE; ENTEROHEPATIC CIRCULATION; FEMALE; FOOD DRUG INTERACTION; FOOD INTAKE; IN VIVO STUDY; MALE; NONHUMAN; PLASMA CLEARANCE; RAT; SEX DIFFERENCE; SPECIES DIFFERENCE;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; BIOTRANSFORMATION; DOGS; FEMALE; HALF-LIFE; INJECTIONS, INTRAVENOUS; MALE; PARTICLE SIZE; PYRAZOLES; RATS; RATS, WISTAR; SPECIES SPECIFICITY; SULFONAMIDES;

EID: 0035682360     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.258     Document Type: Article

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