DNA repair studies: Experimental evidence in support of chicken DT40 cell line as a unique model

Journal of Environmental Pathology, Toxicology and Oncology

Volumn 20, Issue 4, 2001, Pages 273-283

  Dhar, Pawan Kumar ^a   Sonoda, Eiichiro ^a   Fujimori, Akira ^a   Yamashita, Yukiko M ^a   Takeda, Shunichi ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

DNA metabolism; DNA repair; DT40 cell line; Homologous DNA recombination (HR); Nonhomologous end joining (NHEJ)

Indexed keywords

BETA ACTIN; DNA; GENOTOXIC AGENT; HISTONE H3; MUTAGENIC AGENT; OVALBUMIN; TOXIC SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL CELL; CELL LINE; CELL TRANSFORMATION; CHICKEN; CONFERENCE PAPER; DNA DAMAGE; DNA DETERMINATION; DNA METABOLISM; DNA RECOMBINATION; DNA REPAIR; DNA TRANSFECTION; DT 40 CELL LINE; GENE DISRUPTION; MOUSE; MUTATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TEMPERATURE SENSITIVITY; VERTEBRATE;

ANIMALIA; GALLUS GALLUS; MURINAE; VERTEBRATA;

EID: 0035681284     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: 10.1615/jenvironpatholtoxicoloncol.v20.i4.30     Document Type: Conference Paper

References (40)

1. Cell lines derived from avian lymphomas exhibit two distinct phenotypes
2. Rearrangement of chicken immunoglobulin genes is not an ongoing process in the embryonic bursa of Fabricius
3. Selection for B cells with productive IgL gene rearrangements occurs in the bursa of Fabricius during chicken embryonic development
4. A hyperconversion mechanism generates the chicken light chain preimmune repertoire
5. Light chain gene conversion continues at high rate in an ALV-induced cell line
6. Ongoing diversification of the rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line
7. Molecular mechanisms of DNA double strand break repair
8. DNA recombination: The replication connection
9. Radiation-induced mitotic gene conversion frequency in yeast is modulated by the conditions allowing DNA double-strand break repair
10. Topoisomerase I involvement in illegitimate recombination in Saccharomyces cerevisiae
11. Increased ratio of targeted to random integration after transfection of chicken B cell lines
12. RAG-2 expression is not essential for chicken immunoglobulin gene conversion
13. Targeted disruption of an H3-IV/H3-V gene pair causes increased expression of the remaining H3 genes in the chicken cell line
14. Reduced X-ray resistance and homologous recombination frequencies in a RAD54 -/- mutant of the chicken DT40 cell line
15. Homologous recombination, but not DNA repair, is reduced in vertebrate cells deficient in RAD52
16. The essential functions of human Rad51 are independent of ATP hydrolysis
17. Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation
18. The Rad51 paralog Rad51B promotes homologous recombinational repair
19. Possible association of BLM in decreasing DNA double strand breaks during DNA replication
20. Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus
21. Analysis of biological selections for high-efficiency gene targeting
22. Rad51 deficient vertebrate cells accumulate chromosomal breaks prior to cell death
23. Application of FISH technique in normal, transformed and malignant cell lines using alpha pan centromeric DNA probes
24. Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation
25. CENP-C is necessary but not sufficient to induce formation of a functional centromere
26. Targeted disruption of the Rad51 gene leads to lethality in embryonic mice
27. Efficient conditional mutation of the vertebrate CENP-C gene
28. The method for isolation of temperature sensitive mutants in the DT40 cell line
29. The chicken HPRT gene: A counter selectable marker for the DT40 cell line
30. Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice
31. Links between replication, recombination and genome instability in eukaryotes
32. DNA recombination: The replication connection
33. 3-Methyladenine DNA glycosylases: Structure, function, and biological importance
34. Stable DNA replication: Interplay between DNA replication, homologous recombination, and transcription
35. A replication model for sister-chromatid exchange
36. Efficient modification of human chromosomal alleles using recombination-proficient chicken/human microcell hybrids
37. Manipulation of human minichromosomes to carry greater than megabasesized chromosome inserts
38. Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes
39. Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage