Expression of CD44 splice variants in squamous epithelia and squamous cell carcinomas of the head and neck

Journal of Pathology

Volumn 179, Issue 1, 1996, Pages 66-73

  Herold Mende, Christel ^a   Seiter, Simone ^a,b   Born, Antonio I ^a   Patzelt, Erik ^c   Schupp, Michael ^a   Zöller, Joachim ^a   Bosch, Franz X ^a   Zöller, Margot ^a,b,d  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c Research Unit Benderl/Boehringer   (Austria)

^d UNIVERSITY OF KARLSRUHE   (Germany)

Author keywords

CD44 variant isoforms; Metastasis; Squamous cell carcinoma; Squamous epithelium

Indexed keywords

CD44V ANTIGEN; CELL ADHESION MOLECULE; HERMES ANTIGEN;

ADULT; AGED; ARTICLE; CANCER GROWTH; CONTROLLED STUDY; FEMALE; HEAD AND NECK CANCER; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; ALTERNATIVE SPLICING; ANTIBODIES, MONOCLONAL; ANTIGENS, CD44; ANTIGENS, NEOPLASM; CARCINOMA, SQUAMOUS CELL; EPITHELIUM; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; MOUTH; PHARYNX; PRECANCEROUS CONDITIONS;

EID: 0029899820     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199605)179:1<66::AID-PATH544>3.0.CO;2-5     Document Type: Article

References (54)

1. Jalkanen S, Bargatze RF, de los Toyos J, Butcher EC. A lymphoid cell surface protein involved in endothelial eel! recognition and lymphocyte homing in man. Eur J Immunol 1986, 16: 1195-1202.
2. Picker LJ, Nakache M, Butcher EC Monoclonal antibodies to human lymphocyte homing receptors define a novel class of adhesion molecules on diverse cell types. J Cell Biol 1989; 109: 927-937.
3. Lokeshwar VB, Bourguignon LYW Post-translational protein modification and expression of ankyrin-binding site(s) in GP85 (Pgp-1/CD44) and its biosynthetic precursors during T-lymphoma membrane biosynthesis J Biol Chem 1991, 266: 17983-17989
4. Camp RL, Kraus TA, Pure E Variations in the cytoskeletal interaction and posttranslational modification of the CD44 homing receptor in macrophages. J Cell Biol 1991, 115: 1283-1292
5. Omary MB, Trowbridge IS, Letarte M, Kagnoff MF, Isacke CM. Structural heterogeneity of human Pgp-1 and its relationship with p85 Immunogenetics 1988; 27: 460-464.
6. Dougherty GJ, Lansdorp PM, Cooper DL, Humphries RK. Molecular cloning of CD44R1 and CD44R2, two novel isoforms of the human CD44 lymphocyte 'homing' receptor expressed by hemopoietic cells J Exp Med 1991, 174: 1-5
7. Screaton GR, Bell MV, Jackson DO, Cornelis, FB, Gerth U, Bell JI Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc Natl Acad Sci USA 1992; 89: 12160-12164
8. Tölg C, Hofmann M, Herrlich P, Ponta H Splicing choice from ten variant exons establishes CD44 variability. Nucleic Acids Res 1993; 21: 1225-1229
9. Günthet U, Hofmann M, Rudy W, et al. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 1991, 65: 13-24.
10. Jackson DG, Buckley J, Bell JI. Multiple variants of the human lymphocyte homing receptor CD44 generated by insertions at a single site in the extracellular domain. J Biol Chem 1992, 267: 4732-4739.
11. Screaton GR, Bell MV, Bill JI, Jackson DG. The identification of a new alternative exon with highly restricted tissue expression in transcripts encoding the mouse Pgp-1 (CD44) homing receptor. Comparison of all 10 variable exons between mouse, human, and rat. J Biol Chem 1993, 268: 12235-12238
12. Hofmann M, Rudy W, Zöller M, et al. CD44 splice variants confer metastatic behaviour in rats: homologous sequences are expressed in human tumour cell lines. Cancer Res 1991; 51: 5292-5297.
13. Haggerty JG, Bretton RH, Milstone LM. Identification and characterization of a cell surface proteoglycan on keratinocytes. J Invest Dermatol 1992, 99: 374-380.
14. Brown TA, Bouchard T, St John T, Wayner E, Carter WG, Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons J Cell Biol 1991, 113: 207-221
15. Stamenkovic L, Aruffo A, Amiot M, Seed B. The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells. EMBO J 1991, 10: 343-348
16. Cooper DL, Dougherty G, Harn HJ, et al The complex CD44 transcriptional unit: alternative splicing of three internal exons generates the epithelial form of CD44. Biochem Biophys Res Commun 1992, 182: 569-578
17. Kugelman LC, Ganguly S, Haggerty JG, Weissman SM. Milstone LM The core protein of epican, a heparan sulfate proteoglycan on keratinocytes, is an alternative form of CD44 J Invest Dermatol 1992; 99: 381-385.
18. van Weering DH, Baas PD, Bos JL A PCR-based method for the analysis of human CD44 splice products. PCR Methods Applications 1993; 3: 100-106.
19. Günthert U. CD44: a multitude of isoforms with diverse functions Curr Top Microbiol Immunol 1993, 184: 47-63.
20. Haynes BF, Liao HX, Patton KL. The transmembrane hyaluronate recep-tor (CD44): multiple functions, multiple forms Cancer Cells 1991; 3: 347-350.
21. Zöller M. Function of variant isoforms of CD44 in lymphocyte actuation and lymphatic spread of tumor cells. In. Adhesion Molecules and Cell Signalling: Biology and Clinical Applications. Vol. 1 New York: Raven Press, 1995; 201-218
22. Bosworth BT, St John T, Gallatin WM, Harp JA Sequence of the bovine CD44 cDNA: comparison with human and mouse sequences Mol Immunol 1991, 28: 1131-1135
23. Zöller M, Kaufmann M CD44 and metastasis. Onkologie 1994, 17: 114-122
24. Gunthert U, Stauder R, Mayer B, Terpe HJ, Finke L, Friedrichs K Are CD44 variant isoforms involved in human tumour progression? Cancer Surv (in press).
25. Matsumura Y, Tarin D Significance of CD44 gene products for cancer diagnosis and disease evaluation Lancet 1993; 340: 1053-1058.
26. Fox SB, Gatter KC, Jackson DG, et al. CD44 and cancer screening Lancet 1993, 342: 548-549
27. Herrlich P, Zöller M, Pals ST, Ponta H. CD44 splice variants; metastases meet lymphocytes. Immunol Today 1993; 14: 395-399
28. Tanabe KK, Saya H. The CD44 adhesion molecule and metastasis Crit Rev Oncogenesis 1994; 5: 2-3.
29. Sleeman J, Moll J, Sherman L, et al The role of CD44 splice variants in human metastatic cancer Cell Adhesion and Human Disease Ciba Foundation Symposium, No. 189. Chichester. John Wiley. pp 142-156
30. Koopman G, Heider KH, Horst E, et al. Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44. J Exp Med 1993; 177: 897-904.
31. Wielenga VJM, Heider KH, Offerhaus JA, et al Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression Cancer Res 1993; 53: 4754-4756
32. Kaufmann M, Heider KH, Sinn HP, von Minckwitz G, Ponta H, Herrlich P. CD44 variant exon epitopes in primary breast cancer and length of survival Lancet 1995, 345: 615-619.
33. Matsumara Y, Hanbury D, Smith J, Tarin D. Non-invasive detection of malignancy by identification of unusual CD44 gene activity in exfoliated cancer cells Br Med J 1994; 308: 619-624.
34. Tanabe KK, Ellis LM, Saya H Expression of CD44R1 adhesion molecule in colon carcinomas and metastases. Lancet 1993; 341: 725-726.
35. Mayer B, Jauch KW, Günthert U, et al. De novo expression of CD44 and survival in gastric cancer Lancet 1993, 342: 1019-1022
36. Heider KH, Dammrich J, Skroch-Angel P, et al Different expression of CD44 splice variants in intestinal and diffuse type human gastric carcinomas and normal gastric muzcosa. Cancer Res 1993; 53: 4197-4203.
37. Salmi M, Gron-Virta K, Sointu P, Grenman R, Kalimo H, Jalkanen S Regulated expression of exon v6 containing isoforms of CD44 in man: downregulation during malignant transformation of tumors of squamocellular origin. J Cell Biol 1993; 122: 431-442.
38. Penneys NS, Kaiser M. Cylindroma expresses immunohistochemical markers linking it to eccrine coil J Cutan Pathol 1993; 20: 40-43.
39. Kee BL, Dadi HK, Tran-Paterson R, Quackenbush EJ, Andrulis IL, Letarte M. CD10 and CD44 genes of leukemic cells and malignant cell lines show no evidence of transformation-related alterations J Cell Physiol 1991; 148: 414-420.
40. Shtivelman E, Bishop JM. Expression of CD44 is repressed in neuroblastoma cells. Mol Cell Biol 1991, 11: 5446-5453.
41. Cattoretti G, Berti E, Schiró R, D'Amato L, Valeggio C, Rilke F. Improved avidin-biotin-peroxidase complex (ABC) staining. Histochem J 1988; 20: 75-80.
42. Parkin DM, Laara E, Muir CS Estimates of the worldwide frequency of sixteen major cancers in 1980 Int J Cancer 1988; 41: 184-197
43. DeVries N, Gluckmann L. Multiple Primary Tumors in the Head and Neck. Stuttgart Thieme Verlag, 1991.
44. Jakobs C, Makusch R. Efficiency of adjuvant chemotherapy for patients with resectable head and neck cancer: a subset analysis of the head and neck contracts program. J Clin Oncol 1990; 8: 838-847.
45. Rudy W, Hofmann M, Schwartz-Albiez R, et al The two major CD44 proteins expressed on a metastatic rat tumor cell line are derived from different splice variants: each one individually suffices to confer metastatic behavior. Cancer Res 1993; 53: 1262-1268
46. Wirth K, Arch R, Somasundaram C, et al. Expression of CD44 isoforms carrying metastasis-associated sequences in newborn and adult rats. Eur J Cancer 1993, 291:. 1172-1177
47. Fox SB, Fawcett J, Jackson DG, et al. Normal human tissues, in addition to tumours, express multiple different CD44 isoforms. Cancer Res 1994; 54: 4539-4546.
48. Mackay CR, Terpe HJ, Stauder R, Marston WL, Stark H, Günthert U. Expression and modulation of CD44 variant isoforms in humans. J Cell Biol 1994, 124: 71-82.
49. Terpe HJ, Stark H, Prehm P, Günthert U. CD44 variant isoforms are expressed preferentially in basal epithelia of non-malignant human fetal and adult tissues, Histochemistry 1994; 101: 79-89
50. Terpe A, Franke F, Stark H, Gustmann C, Mackay W, Günthert U. Occurrence of CD44 and its isoforms under orthological and pathological conditions. Verh Dtsch Ges Pathol 1993; 77: 276-281
51. Arch R, Wirth K, Hofmann M, et al. Participation in normal immune responses of a metastasis-inducing splice variant of CD44. Science 1992; 257: 682-685.
52. Moll J, Schmidt A, van der Putten H, Plug R, Ponta H, Herrlich P, Zöller M. Accelerated T cell responsiveness in variant CD44 expressing transgenic mice J Immunol in press.
53. Seiter S, Schadendorf D, Herrmann K, Schneider M, Rölsel M, Arch R, Tilgen W, Zöller M Expression of splice variants of CO44 during melanoma progression Clin Cancer Res in press
54. Seiter S, Herrmann K, Möller P, Patzelt, Tilgen W, Zöller M Expression of splice variant of CD44 on human skin and epidermal tumours. Virchow's Archiv Pathol, in press.