αvβ6 integrin upregulates matrix metalloproteinase 9 and promotes migration of normal oral keratinocytes

Journal of Investigative Dermatology

Volumn 116, Issue 6, 2001, Pages 898-904

  Thomas, Gareth J ^a,b   Poomsawat, S ^a   Lewis, Mark P ^a   Hart, Ian R ^b   Speight, Paul M ^a   Marshall, John F ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Integrins; Keratinocytes; Metalloproteinases; Migration

Indexed keywords

FIBRONECTIN RECEPTOR; GELATINASE B; INTEGRIN; PLASMIN;

ARTICLE; CELL ADHESION; CELL MIGRATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WOUND HEALING;

EID: 0034984231     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2001.01352.x     Document Type: Article

References (45)

1. Expression of β1, β3, β4 and β5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes
2. Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer
3. The αvβ6 integrin promotes proliferation of colon carcinoma cells through a unique region of the β6 cytoplasmic domain
4. Expression of the β6 subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling
5. Restricted distribution of integrin beta 6 mRNA in primate epithelial tissues
6. Localization of matrix-metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin αvβ3
7. 51Cr-release assay as used for the quantitative measurement of cell-mediated cytolysis in vitro
8. Distinctive integrin expression in the newly forming epidermis during wound healing in humans
9. Cutaneous wound repair: Basic biological considerations
10. Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reepithelialisation
11. Reepithelialization of normal human excisional wounds is associated with a switch from αvβ5 to αvβ6 integrins
12. Signal transduction by integrin receptors for extracellular matrix: Cooperative processing of extracellular information
13. Disaggregation of the tissue and primary culture
14. Induction of cell migration by matrix metalloproteinase-2 cleavage of laminin-5
15. Activation of human keratinocyte migration on type I collagen and fibronectin
16. Keratinocytes in human wounds express αvβ6 integrin
17. Inactivation of the integrin β6 subunit reveals a role of epithelial integrins in regulating inflammation in the lungs and skin
18. The integrin αvβ6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin
19. Cooperative signaling by α5β5 and α4β1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin
20. Integrins: Versatility, modulation, and signaling in cell adhesion
21. Restoration of αvβ5 integrin in neoplastic keratinocytes results in increased capacity for terminal differentiation and suppression of anchorage independent growth
22. v integrins in oral squamous cell carcinoma
23. Role and regulation of expression of 92-kDa type-IV collagenase (MMP-9) in 2 invasive squamous cell carcinoma cell lines of the oral cavity
24. Mechanism of human keratinocyte migration on fibronectin: Unique roles of RGD site and integrins
25. Integrin receptors and RGD sequences in human keratinocyte migration: Unique anti-migratory function of alpha 3 beta 1 epiligrin receptor
26. Vitronectin-driven human keratinocyte locomotion is mediated by the alph v beta 5 integrin receptor
27. Secretion of different types of gelatinases from cultured human keratinocytes
28. Differential regulation of MMP-2 and MMP-9 gelatinases in cultured human keratinocytes
29. Anti-integrin antibodies induce type-IV collagenase expression in keratinocytes
30. Functional overlap between two classes of matrix-degrading proteases in wound healing
31. Matrix metalloproteinase-2 (gelatinase A) is related to migration of keratinocytes
32. Epidermal growth factor (EGF)- and scatter factor/hepatocyte growth factor (SF/HGF)-mediated keratinocyte migration is coincident with induction of matrix metalloproteinase (MMP)-9
33. Integrin mediated signalling of gelatinase B secretion in colon carcinoma cells
34. Demonstration of 72-kDa and 92-kDa fonns of type IV collagenase in human skin: Variable expression in various blistering diseases, induction during re-epithelialization, and decrease by topical glucocorticoids
35. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness
36. The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix
37. Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion
38. Matrix metalloproteinases in wound repair
39. Transforming growth factor-β1 upregulates type IV collagenase expression in cultured human keratinocytes
40. Expression of matrix metalloproteinase-2 and -9 during early human wound healing
41. The 72kDa type IV collagenase is modulated via differential expression of alpha v beta 3 and alpha 5 beta 1 integrins during human melanoma cell invasion
42. Urokinase receptor (uPAR/CD87) is a ligand for integrins and mediates cell-cell interaction
43. αvβ6 integrin promotes invasion by squamous carcinoma cells through upregulation of MMP-9
44. Fibronectin receptors of human keratinocytes and their expression during cell culture
45. Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor