No evidence of deregulated patched-hedgehog signaling pathway in trichoblastomas and other tumors arising within nevus sebaceous

Journal of Investigative Dermatology

Volumn 117, Issue 6, 2001, Pages 1666-1670

  Takata, Minoru ^a   Tojo, Michiko ^b   Hatta, Naohito ^a   Ohara, Kuniakis ^c   Yamada, Mizuki ^c   Takehara, Kazuhiko ^b  

^a KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

^b FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^c TORANOMON HOSPITAL   (Japan)

Author keywords

Adnexal and skin appendage; Basal cell, carcinoma; In situ hybridization; Loss of heterozygosity; Microsatellite repeats, neoplasms

Indexed keywords

MESSENGER RNA;

ADOLESCENT; ADULT; AGED; ARTICLE; BASAL CELL CARCINOMA; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MALE; MORPHOLOGY; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEBACEOUS NEVUS; SIGNAL TRANSDUCTION; TRICHOBLASTOMAS; TUMOR;

EID: 0035671651     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-202x.2001.01581.x     Document Type: Article

References (30)

1. Trichoblastoma
2. Ultraviolet and ionizing radiation enhance the growth of BCC and trichoblastomas in patched heterozygous knockout mice
3. The pilosebaceous tumors
4. Tumors arising in nevus sebaceus: A study of 596 cases
5. Linear nevus sebaceous with convulsions and mental retardation
6. The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas
7. Basal cell carcinoma development is associated with induction of the expression of the transcription factor Gli-1
8. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
9. How many epidermal nevus syndromes exist? A clinicogenetic classification
10. Lethal genes surviving by mosaicism: A possible explanation for sporadic birth defects involving the skin
11. Differentiating neoplasms of hair germ
12. Trichoblastoma is the most common neoplasm developed in nevus sebaceus of Jadassohn: A clinicopathologic study of a series of 155 cases
13. Human homolog of patched, a candidate gene for the basal cell nevus syndrome
14. Frequent clones of p53-mutated keratinocytes in normal human skin
15. Basaloid neoplasms in nevus sebaceus
16. Life history of organoid nevus
17. The natural history of nevus sebaceus
18. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1
19. Fibroblast-dependent induction of a murine skin lesion similar to human nevus sebaceus of Jadassohn
20. Merkel cells are absent in basal cell carcinomas but frequently found in trichoblastomas. An immunohistochemical study
21. PCR artifacts in LOH and MSI analysis of microdissected tumor cells
22. Nevus sebaceous
23. Low frequency of loss of heterozygosity at the nevoid basal cell carcinoma locus and other selected loci in appendageal tumors
24. Low frequency of genetic change in p53 immunopositive clones in human epidermis
25. Genetic changes in sweat gland carcinomas
26. Expression of sonic hedgehog signal transducers, patched and smoothened, in human basal cell carcinoma
27. Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma
28. The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched
29. Naevus sebaceus. A report of 140 cases with special regard to the development of secondary malignant tumours
30. The sebaceous nevus: A nevus with deletions of the PTCH gene