Enumeration of bone marrow ‘homing’ haemopoietic stem cells from G-CSF-mobilised normal donors and influence on engraftment following allogeneic transplantation

Bone Marrow Transplantation

Volumn 28, Issue 11, 2001, Pages 1019-1022

  Spencer, A ^a   Jackson, J ^a   Baulch Brown, C ^a  

^a ALFRED HOSPITAL   (Australia)

Author keywords

Allogeneic transplant; CXCR4; Engraftment

Indexed keywords

CD34 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; GRANULOCYTE COLONY STIMULATING FACTOR; METHOTREXATE;

ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CELL ISOLATION; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; DONOR; FREQUENCY ANALYSIS; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL; HUMAN; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECIPIENT; STEM CELL; THROMBOCYTE;

ADULT; BONE MARROW; BONE MARROW CELLS; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKOCYTE COUNT; TISSUE DONORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 0035666193     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1703289     Document Type: Article

References (12)

1. The chemokine receptor CXCR-4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1
2. Chemotaxis of primitive hematopoietic cells in response to stromal cell-derived factor-1
3. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4
4. The ISHAGE guidelines for CD34+ cell determination by flow cytometry
5. Cord blood progenitor cells have greater transendothelial migratory activity and increased responses to SDF-1 and MIP-3beta compared with mobilized adult progenitor cells
6. The biology and clinical uses of blood stem cells
7. An analysis of engraftment kinetics as a function of the CD34 content of peripheral blood progenitor cell collections in 692 patients after the administration of myeloablative chemotherapy
8. Peripheral blood stem cell transplants for multiple myeloma: Identification of favourable variables for rapid engraftment in 225 patients
9. High CD34(+) cell counts decrease hematologic toxicity of autologous peripheral blood progenitor cell transplantation
10. Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice
11. The human hematopoietic stem cell compartment is heterogeneous for CXCR4 expression
12. The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood