Possible involvement of increased susceptibility of LDL to oxidation in age-related platelet activation

Clinical Hemorheology and Microcirculation

Volumn 25, Issue 1, 2001, Pages 13-20

  Di Massimo, C ^a   Penco, M ^a   Serri, F ^a   Tozzi Ciancarelli, M G ^b  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Elderly; Nitric oxide; Ox LDL; Platelet sensitivity

Indexed keywords

CALCIUM; COLLAGEN; LOW DENSITY LIPOPROTEIN; NITRATE; NITRITE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ADULT; AGE; AGED; AGING; ANTIOXIDANT ACTIVITY; ARTICLE; BIOAVAILABILITY; BLOOD LEVEL; CALCIUM CELL LEVEL; CELL MEMBRANE FLUIDITY; CONTROLLED STUDY; CYTOSOL; HUMAN; LIPID PEROXIDATION; MALE; NORMAL HUMAN; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE MEMBRANE;

ADULT; AGED; AGING; BLOOD PLATELETS; CALCIUM; FREE RADICAL SCAVENGERS; HUMANS; LIPID PEROXIDATION; LIPOPROTEINS, LDL; MALE; MEMBRANE FLUIDITY; MIDDLE AGED; NITRIC OXIDE; OXIDATION-REDUCTION; PLATELET ACTIVATION; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0035666133     PISSN: 13860291     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. N.G. Ardlie, M.L. Selley and L.A. Simons, Platelet activation by oxidatively modified low density lipoproteins, Atherosclerosis 76 (1989), 117-124.
2. R. Busse, A. Luckhoff and E. Bassenge, Endothelium-derived relaxing factor inhibits in vitro platelet aggregation, Naunyn-Schmiderberg's Arch. Pharmacol. 336 (1987), 566-571.
3. M. Challah, S. Nadaud, M. Philippe, T. Battle, F. Soubrier, B. Corman and J.B. Michel, Circulating and cellular markers of endothelial dysfunction with aging in rats, Am. J. Physiol. 273 (1997), H1941-HI948.
4. A. Chauhan, R.S. More, P.A. Mullins, G. Taylor, C. Fetch and P.M. Schofield, Aging-associated endothelial dysfunction in humans is reversed by L-arginine, J. Am. Coll. Cardiol. 28 (1996), 1796-1804.
5. L.Y. Chen, P. Metha and J.L. Metha, Oxidized LDL decreases L-arginine uptake and nitric oxide synthase protein expression in human platelets, Circulation 93 (1996), 1740-1746.
6. F. Congy, D. Bonnefont-Rousselot, S. Dever, J. Delattre and J. Emerit, Study of oxidative stress in the elderly, Presse Med. 24(1995), 1115-1118.
7. C. Di Massimo, G. Taglieri, M. Penco and M.G. Tozzi-Ciancarelli, Influence of aging and exercise-induced stress on human platelet function, Clin. Hemorheol. Microcirc. 20 (1999), 105-110.
8. G. Gleerup and K. Winther, The effect of ageing on platelet function and fibrinolytic activity, Angiologv 46 (1995), 715-718.
9. M.B. Grisham, G.G. Johnson and J.R. Lancaster, Quantitation of nitrate and nitrite in extracellular fluids, Methods Enzymol. 268(1996), 237-246.
10. D. Harman, The aging process: major risk factor for disease and death, Proc. Natl. Acad. Sei. USA 88 (1991), 5360-5363.
11. J.K. Liao, W.S. Shin, W.Y. Lee and S.L. Clark, Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase, J. Biol. Chem. 270 (1995), 319-324.
12. M. Liu, R. Bergholm, S. Makimattila, S. Lahdenpeira, M. Valkonen, H. Hilden, H. Yki-Jarvinen and M. Taskinen, A marathon run increases the susceptibility of LDL to oxidation in vitro and modifies plasma antioxidants, Am. J. Physiol. 276(1999), E1083-E1091.
13. T.F. Luscher and F.C. Tanner, Endothelial regulation of vascular tone and growth, Am. J. Hypertens. 6 ( 1993), 283S-293S.
14. J.L. Mehta and L.Y. Chen, Reversal by high-density lipoprotein of the effect of oxidized low-density lipoprotein on nitric oxide synthase protein expression in human platelets, J. Lab. Clin. Med. 127 (1996), 287-295.
15. N.J. Miller, C. Rice-Evans, M.J. Davies, V. Gopinathan and A. Milner, A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates, Clin. Sei. 84 (1993), 407-12.
16. T.P. Misko, R.J. Schilling, D. Salvemini, W.M. Moore and M.G. Currie, A fluorometric assay for the measurement of nitrite in biological samples, Anal. Biochem. 214 (1993), 11-16.
17. A. Mugge, U. Forestermann and P.R. Lichtlen, Platelet endothelium-dependent responses and atherosclerosis, Ann. Med. 23(I991),545-550.
18. B.L. Nguyen, M. Saitohand J.A.Ware, Interaction of nitric oxide and cGMP with signal transduction in activated platelets, Am. J. Physiol. 261 (1991), H1043-H1052.
19. M.W. Radomski, R.M. Palmer and S. Moncada, An L-arginine/nitric oxide pathway present in human platelets regulates aggregation, Proc. Natl. Acad. Sei. USA 87 (1990), 5193-5197.
20. I. Sato, K. Kaji, I. Morita, M. Nagao and S. Murota, Augmentation of endothelin-1, prostaclyclin and thromboxane A2 secretion associated with in vitro ageing in cultured human umbilical vein endothelial cells, Mech. Ageing Dev. 71 (1993), 73-84.
21. C.K. Sen, T. Rankinen, S. Vaisanen and R. Rauramaa, Oxidative stress after human exercise: effect of N-acetylcysteine supplementation, J. Appl. Physiol. 76 (1994), 2570-2577.
22. M. Toprakci, D. Ozmen, I. Mutaf, N. Turgan, Z. Parildar, S. Habif, I. Guner and O. Bayindir, Age-associated changes in nitric oxide metabolites nitrite and nitrate, Int. J. Clin. Lab. Res. 30 (2000), 83-85.
23. M.G. Tozzi-Ciancarelli, C. Di Massimo, E. Tozzi, A. Mascioli, G. De Matteis and A. Carolei, Influence of a selective 5HTi-receptor agonist GR43175 on platelet responsiveness, Cephalalgia 15 (1995), 472-76.
24. M.G. Tozzi-Ciancarelli, G. De Matteis, C. Di Massimo, C. Marini, I. Ciancarelli and A. Carolei, Oxidative stress and platelet responsiveness in migraine, Cephalalgia 17(1997), 580-584.
25. E. Vericel, M. Croset, P. Sedivy, P. Courpron, M. Dechavanne and M. Lagarde, Platelets and aging. I - Aggregation, arachidonate metabolism and antioxidant status, Thromb. Res. 49 (1988), 331-342.