Activation of a T cell hybridoma by an alloligand results in differential effects on IL-2 secretion and activation-induced cell death

European Journal of Immunology

Volumn 31, Issue 12, 2001, Pages 3825-3832

  Qadri, Ayub ^a,b   Ward, E Sally ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

Author keywords

Activation induced cell death; Alloreactivity; TCR peptide MHC complex

Indexed keywords

ALLOANTIGEN; AUTOANTIGEN; EPITOPE; FAS LIGAND; INTERLEUKIN 2; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELIN BASIC PROTEIN; T LYMPHOCYTE RECEPTOR;

ACETYLATION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIGEN RECOGNITION; APOPTOSIS; ARTICLE; BETA CHAIN; CELL DEATH; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE RELEASE; HYBRIDOMA; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOOTPRINTING; T LYMPHOCYTE ACTIVATION;

ANIMALS; APOPTOSIS; CELL LINE; HISTOCOMPATIBILITY ANTIGENS; HYBRIDOMAS; INTERLEUKIN-2; LIGANDS; LYMPHOCYTE ACTIVATION; MICE; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 0035664123     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200112)31:12<3825::AID-IMMU3825>3.0.CO;2-O     Document Type: Article

References (45)

1. Hypothesis: Why do so many lymphocytes respond to major histocompatibility antigens?
2. Positive selection of lymphocytes
3. Selective events in T cell development
4. Positive selection of thymocytes
5. The molecular basis of allorecognition
6. An αβ T cell receptor structure at 2.5 °A and its orientation on the TCR-MHC complex
7. Structure of the complex between human T cell receptor, viral peptide and HLA-A2
8. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids
9. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen
10. The crystal structure of a T cell receptor in complex with peptide and MHC class II
11. High determinant density may explain the phenomenon of alloreactivity
12. b by alloreactive cytotoxic T lymphocytes
13. Cytotoxic T lymphocytes recognise a reconstituted class I histocompatibility antigen (HLA-A2) as an allogeneic target molecule
14. Conformational differences in major histocompatibility complex-peptide complexes can result in alloreactivity
15. High affinity reactions between antigen specific T cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins
16. + T cell recognition of class I MHC molecules
17. Peptide independent recognition by alloreactive cytotoxic T lymphocytes (CTL)
18. Role of peptides in allorecognition
19. + T cell responses
20. + T cell response directed against a single MHC class II/peptide combination
21. Crystal structure of a T cell receptor bound to an allogeneic MHC molecule
22. d peptide complexes
23. Vaccination with a recombinant Vα domain of a TCR prevents the development of collagen-induced arthritis
24. Expression and characterisation of recombinant soluble peptide:I-A complexes associated with murine experimental autoimmune diseases
25. An autoantigenic T cell epitope forms unstable complexes with class II MHC: A novel route for escape from tolerance induction
26. Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: Possible role of T cell bound Ia antigens as targets of immunoregulatory T cells
27. Characterisation of the interaction of a TCR α chain variable domain with MHC class II I-A molecules
28. k form and dissociate rapidly at neutral pH
29. The role of peptides in T cell alloreactivity is determined by self-major histocompatibility molecules
30. Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
31. T cell receptor affinity and thymocyte positive selection
32. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists
33. Structure of a covalently stabilized complex of a human αβ T cell receptor, influenza HA peptide and MHC class II molecule. HLA-DR1
34. The bacterial and mouse mammary tumor virus superantigens: Two different families of proteins with the same functions
35. Inhibition of allorecognition by a human class II MHC derived peptide through the induction of apoptosis
36. An MHC interaction site maps to the amino-terminal half of the T cell receptor α chain variable domain
37. A basis for alloreactivity: MHC helical residues broaden peptide recognition by the TCR
38. Role of 2C T cell receptor residues in the binding of self- and allo-major histocompatibility complexes
39. MHC-binding peptides for immunotherapy of experimental autoimmune disease
40. u
41. Characterisation of murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor
42. Antigen recognition in autoimmune encephalomyelitis and the potential for peptide mediated immunotherapy
43. Measurement of human and mouse interleukin 2 and interleukin 4
44. A role for the region encompassing the c strand of a TCR V alpha domain in T cell activation events
45. Induction of apoptosis in mature T cells by tumor necrosis factor