Dual effects of sulfated D-galactans from the red algae Botryocladia occidentalis preventing thrombosis and inducing platelet aggregation

Thrombosis and Haemostasis

Volumn 86, Issue 6, 2001, Pages 1540-1546

  Farias, W R L ^a   Nazareth, R A ^a   Mourao P A S ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Algal polysaccharide; Anticoagulant activity; Antithrombotic action; Platelet aggugation; Sulfated galactan

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A; DEXTRO GALACTAN; GALACTAN; HEPARIN; HEPARIN COFACTOR II; POLYSACCHARIDE SULFATE; THROMBIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; BLEEDING; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; DRUG STRUCTURE; DRUG SULFATION; EXPERIMENTAL MODEL; FEMALE; HEMOSTASIS; HYPERCOAGULABILITY; INHIBITION KINETICS; MALE; NONHUMAN; PLOTS AND CURVES; PRIORITY JOURNAL; RAT; RED ALGA; THROMBOCYTE AGGREGATION; THROMBOGENESIS; THROMBOSIS;

EID: 0035657212     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1616760     Document Type: Article

References (46)

1. Isolation, fractionation, and preliminary characterization of a novel class of sulfated glycans from the tunic of Styela plicata (Chordata, Tunicata)
2. Structural features of sulfated glycans from the tunic of Styela plicata (Chordata-Tunicata): A unique occurrence of L-galactose in sulfated polysaccharides
3. Highly acidic glycans from sea cucumbers: Isolation and fractionation of fucose-rich sulfated polysaccharides from the body wall of Ludwigothurea grisea
4. Occurrence of a unique fucose-branched chondroitin sulfate in the body wall of a sea cucumber
5. Structural heterogeneity among unique sulfated L-galactans from different species of ascidians (Tunicates)
6. Structural of a fucose-branched chondroitin sulfate from sea cucumber: Evidence for the presence of 3-O-sulfo-β-D-glucuronosyl residues
7. Structural diversity among sulfated α-L-galactans from ascidians (tunicates): Studies on the species Ciona intensinalis and Herdmania monus
8. Sulfated fucans from echinoderms have a regular tetrasaccharide repeating unit defined by specific patterns of sulfation at the O-2 and O-4 positions
9. A unique dermatan sulfate-like glycosaminoglycan from ascidian: Its structure and the effect of its unusual sulfation pattern on coagulation activity
10. Sulfated polysaccharides from the egg jelly layer are species-specific inducers of acrosomal reaction in sperms of sea urchins
11. Females of the sea urchin Strongylocentrotus purpuratus differ in the structure of their egg jelly sulfated fucans
12. Structure of the sulfated α-L-fucan from the egg jelly coat of the sea urchin Strongylocentrotus franciscanus: Patterns of preferential 2-O- and 4-O-sulfation determine sperm cell recognition
13. Structure and anticoagulant activity of a fucosylated chondroitin sulfate from echinoderm: Sulfated fucose branches on the polysaccharide account for its high anticoagulant action
14. Highly sulfated dermatan sulfate from ascidians: Structure versus anticoagulant activity of these glycosaminoglycans
15. Antithrombotic activity of a fucosylated chondroitin sulfate from echinoderm: Sulphated fucose branches on the polysaccharide account for its antithrombotic action
16. Different antithrombotic mechanisms among glycosaminoglycans revealed with a new fucosylated chondroitin sulfate from echinoderm
17. Structure and anticoagulant activity of sulfated fucans: Comparison between the regular, repetitive, and linear fucans from echinoderms with the more heterogeneous and branched polymers from brown algae
18. Structure and anticoagulant activity of sulfated galactans. Isolation of a unique sulfated galactan from the red algae Botryocladia occidentalis and comparison of its anticoagulant action with that of sulfated galactans from invertebrates
19. Improved quantitation and discrimination of sulfated glycosaminoglycans by use of dimethylmethylene blue
20. Colorimetric method for determination of sugars and related substance
21. Anticoagulant properties of heparin fractionated by affinity chromatography on matrix-bound antithrombin-3 and by gel-filtration
22. Anticoagulant effect of heparan sulfate and dermatan sulfate
23. Assay of dermatan sulfate cofactor (Heparin-cofactor II) activity in human-plasma
24. Comparison of two experimental thrombosis models in rats: Effect of four glycosaminoglycans
25. Biochemical and pharmacological properties of SANORG 32701. Comparison with the "synthetic pentasaccharide (SR 90107/org 31540)" and standard heparin
26. Enzymatic methods for the determination of small quantities of isometric chondroitin sulfates
27. Heparinoide-active sulphated polysaccharides from Monostroma nitidum and their distribution in the chlorophyta
28. Anticoagulant activity of a proteoglycan in extracts of Codium fragile ssp. atlanticum
29. Chemical characterization of cell-wall polysaccharides from tank-cultivated and wild plants of Delesseria sanguinea (Hudson) Lamouroux (Ceramiales-Delesseriaceae): Culture patterns and potent anticoagulant activity
30. A new sulfated polysaccharide with potent blood anticoagulant activity from the red seaweed Grateloupia indica
31. The system of sulfated α-(1→3) linked D-mannans from the red seaweed Nothogenia fastigiate: Structures, antiherpetic and anticoagulant properties
32. New natural polysaccharides with potent antithrombotic activity: Fucans from brown algae
33. Antithrombin activity of a fucan sulfate from the brown seaweed Acklonia kurome
34. Antithrombin activity of fucoidan. The interaction of fucoidan with heparin cofactor II, antithrombin III, and thrombin
35. Anticoagulant properties of a fucoidan fraction
36. A low molecular weight fucoidan from the brown seaweed Pelvetia canaliculata
37. Importance of platelets in experimental venous thrombosis in the rat
38. The coagulation cascade: Initiation, maintenance and regulation
39. Heparin-induced thrombocytopenia: A clinicopathologic syndrome
40. Heparin-induced thrombocytopenia: Molecular pathogenesis
41. Heparin induced bleeding
42. The heparin induced thrombosis-thrombocitopenia syndrome (HITTS): A review
43. New class of heparin derivatives with a potent antithrombotic effect and a very limited hemorrhagic activity
44. Does low molecular weight heparin cause less bleeding?
45. Heparin: Mechanism of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety
46. Oral anticoagulants. Mechanism of action, clinical effectiveness, and optimal therapeutic range