The effects of iron deficiency on lymphocyte cytokine production and activation: Preservation of hepatic iron but not at all cost

Clinical and Experimental Immunology

Volumn 126, Issue 3, 2001, Pages 466-473

  Jason, J ^a,c   Archibald, L K ^b   Nwanyanwu, O C ^c   Bell, M ^b   Jensen, R J ^d   Gunter, E ^d   Buchanan, I ^a   Larned, J ^a   Kazembe, P N ^e,f   Dobbie, H ^e,f   Jarvis, W R ^b  

^a TB Laboratory Research (DASTLR)   (Malawi)

^b Investigation and Prevention Branch   (Malawi)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^d NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

^e Lilongwe Central Hospital   (Malawi)

^f MINISTRY OF HEALTH   (Malawi)

Author keywords

Cytokines; IL 4; IL 6; Iron deficiency; Lymphocyte activation; Transferrin receptor

Indexed keywords

CD38 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 6; IRON; TUMOR NECROSIS FACTOR ALPHA;

ACUTE DISEASE; ADOLESCENT; ANEMIA; ARTICLE; CHILD; CONTROLLED STUDY; COST; CYTOKINE PRODUCTION; DIAGNOSTIC TEST; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HOSPITAL ADMISSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IRON DEFICIENCY; IRON METABOLISM; IRON STORAGE; IRON TRANSPORT; LYMPHOCYTE ACTIVATION; MAJOR CLINICAL STUDY; MALE; NEWBORN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; REGRESSION ANALYSIS; STATISTICAL MODEL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRANSFERRIN BLOOD LEVEL;

ADOLESCENT; ANEMIA, IRON-DEFICIENCY; CHILD; CHILD, PRESCHOOL; CYTOKINES; FEMALE; HUMANS; IMMUNITY, CELLULAR; INFANT, NEWBORN; INTERFERON TYPE II; INTERLEUKIN-6; IRON; LIVER; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MALE; RECEPTORS, TRANSFERRIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035652018     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2001.01707.x     Document Type: Article

References (32)

1. The prevalence of anaemia in the world
2. The liabilities of iron deficiency
3. Trace element regulation of immunity and infection
4. Evaluation of neutrophil and lymphocyte function in subjects with iron deficiency
5. Iron status, immune capacity and resistance to infection
6. Iron deficiency, infections, and immune function: A reassessment
7. Iron and immunity
8. Limitations of ferritin as a marker of anemia in end stage renal disease
9. Structure, function and clinical significance of transferrin receptors
10. The immune response in iron-deficient young children: Effect of iron supplementation on cell-mediated immunity
11. Plasma transferrin receptor levels and indices of erythropoiesis and iron status in healthy term infants
12. Serum transferrin receptor and transferrin receptor-ferritin index identify healthy subjects with subclinical iron deficits
13. Diagnostic utility of serum transferrin receptors measurement in assessingiron status
14. Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia
15. Assessment of iron status in cystic fibrosis patients
16. Serum transferrin receptor
17. Higher concentrations of serum transferrin receptor in children than adults
18. Immune determinants of organism and outcome in febrile hospitalized Thai patients with bloodstream infections
19. Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations
20. Soluble transferrin receptor as an index of iron status in Zaïrian children with malaria
21. Analytical and clinical implications of soluble transferrin receptors in serum
22. Circulating transferrin receptor assay - Coming of age
23. Interleukin-8 levels in human lung epithelial cells are increased in response to coal fly ash and vary with the bioavailability of iron, as a function of particle size and source of coal
24. Interleukin-6 enhances hepatic transferrin uptake and ferritin expression in rats
25. Regulation of iron metabolism in HepG2 cells: A possible role for cytokines in the hepatic deposition of iron
26. Interleukin 6: A multifunctional cytokine regulating immune reactions and the acute phase protein response
27. In vivo effects of recombinant human interleukin-6 in primates: Stimulated production of platelets
28. Modulation of iron metabolism in monocyte cell line U937 by inflammatory cytokines: Changes in transferrin uptake, iron handling and ferritin mRNA
29. High-dose recombinant human erythropoietin stimulates reticulocyte production in patients with multiple organ dysfunction syndrome
30. Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13
31. Synergy of tumor necrosis factor and interleukin 2 in the activation of human cytotoxic lymphocytes: Effect of tumor necrosis factor-α and interleukin 2 in the generation of human lymphokine-activated killer cell cytotoxicity
32. Generation of activated killer (AK) cells by recombinant interleukin 2 in collaboration with interferon-γ