Effect of multidrug resistance modulators on the activity of ivermectin and moxidectin against selected strains of Haemonchus contortus infective larvae

Pesquisa Veterinaria Brasileira

Volumn 21, Issue 3, 2001, Pages 117-121

  Molento, Marcelo B ^a   Prichard, Roger K ^a,b  

^a UNIVERSIDADE PARANAENSE   (Brazil)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

CL 347.099; Cyclosporin A; Ivermectin; Modulators; Moxidectin; Multidrug resistance (MDR); Nematode; Verapamil

Indexed keywords

EID: 0035597358     PISSN: 0100736X     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0100-736X2001000300004     Document Type: Article

References (22)

1. Armson A., Cunninghan G.A., Grubb W.B. & Mendis A.H. 1995. Murine strongyloldiasls: The effects of cyclosporin A and thiabendazole administered singly and in combination. Int. J. Parasitol. 25:533-535.
2. Blackhall W., Liu H.Y., Xu M., Prichard R. & Beech R. 1998. Selection at a P-glycoprotein gene in ivermectin and moxidectin-selected strains of Haemonchus contortus. Mol. Biochem. Parasitol. 95:193-201.
3. Broeks A., Janssen H.W., Calafat J. & Plasterk R.H. 1995. A P-glycoprotein protects Caenorhabditis elegans against natural toxins. EMBO 14:1858-1866.
4. Carmichael I.H., Visser R., Schneider D. & Soll M.D. 1987. Haemonchus contortus resistance to ivermectin. J. South Afr. Vet. Assoc. 58:93.
5. D'Assonville J. A., Janovsky E. & Versley A. 1996. In vitro screening of Haemonchus contortus third stage larvae for ivermectin resistance. Vet. Parasitol. 61:73-80.
6. Didier A. & Loor F. 1996. The abamectin derivative ivermectin is a potent P-glycoprotein inhibitor. Anti-Cancer Drugs 7:745-751.
7. Greenberger L.M., Collins K.I., Annable T., Boni J.P., May M.K., Lai F.M., Kramer R., Citeralla R.V., Hallett W.A. & Powell D. 1996. a-(3,4-dimethyoxyphenyl)-3, 4-dihydro-6, 7-dimethoxy-a-[(4-methylphenyl) thio]-2(1H)-isoquinolineheptanenitrile (CL 329,753): A novel chemosensitizing agent for P-glycoprotein-mediated resistance with improved biological properties compared with verapamil and cyclosporin A. Oncol. Res. 8:207-218.
8. Holm P.S., Dietel M. & Scallon K. 1994. Reversion of multidrug resistance in the P-glycoprotein-positive human pancreatic cell line (EPP85-181RDB) by introduction of a hammerhead ribozyme. Brit. J. Cancer. 70:239-243.
9. Leathwick D.M. 1995. A case of moxidectin failing to control ivermectin resistant Ostertagia species in goats. Vet. Rec. 136:443-444.
10. 2+ channel density in rat cardiac tissue. Pharmacol. 49:23-3.
11. Lum B.L., Fisher G.A., Brophy N.A., Yahanda A.M., Adler K.M., Kaubisch S., Halsey J. & Sikic B.I. 1993. Clinical trials of modulation of multidrug resistance. Cancer 72:3502-3514.
12. Molento M.B. & Prichard R.K. 1999. Effects of the multidrug-resistance-reversing agent, verapamil and CL 347,099, on the efficacy of ivermectin or moxidectin against unselected and drug-selected strains of Haemonchus contortus in jirds (Meriones unguiculatus). Parasitol. Res. 85:1007-1011.
13. Molento M.B., Lifschitz A., Sallovitz J., Lanusse C. & Prichard R. 1999. Verapamil modifies the pharmacokinetics of ivermectin in sheep, p. d.1.01. In: Proceedings of the XVII International Conference of the World Association for the Advancement of Veterinary Parasitology, Copenhagen, Denmark.
14. Pouliot J.F., L'Heureux F., Liu Z., Prichard R.K. & Georges E. 1997. Reversal of P-glycoprotein-associated multidrug resistance by ivermectin. Biochem. Pharmacol. 53:17-25.
15. Sangster N., Bannan S., Weiss A., Nulf S., Klein R. & Geary T. 1999. Haemonchus contortus: sequence heterogeneity of nucleotide binding domains from P-glycoproteins and an association with avermectin/milbemycin resistance. Exp. Parasitol. 91:250-257.
16. Shustik C., Dalton W. & Gros P. 1995. P-glycoprotein-mediated multidrug resistance in tumor cells. Biochemistry, clinical relevance and modulation. Mol. Aspects Med. 16:1-78.
17. Wadkins R.M. & Roepe P.D. 1997. Biophysical aspects of P-glycoprotein-mediated multidrug resistance. Int. Rev. Cytol. 171:121-165.
18. Wang G.T., Berger H., Simkins K. & Rock D. 1995. The rate of resistance development by H. contortus to endectocides, p.104. In: Proceedings of the XV International Conference of the World Association for the Advancement of Veterinary Parasitology, Yokohama, Japan.
19. Waruiru R.M. 1997. Efficacy of closantel, albendazole and levamisole on an ivermectin resistant strain of Haemonchus contortus in sheep. Vet. Parasitol. 73:65-71.
20. Watanabe T., Tsuge H., Oh-Hara T., Naito M. & Tsuruo T. 1995. Comparative study on reversal efficacy of SDZ PSC 833, cyclosporin A and verapamil on multidrug resistance in vitro and in vivo. Acta Oncol. 34:235-241.
21. Xu M., Molento M., Blackhall W., Ribeiro P., Beech R. & Prichard R. 1998. Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog. Mol. Biochem. Parasitol. 91:327-335.
22. Yusa K. & Tsuro T. 1989. Reversal mechanism of multidrug resistance by verapamil: Direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ ADM cells. Cancer Res. 49:5002-5006.