Suppression of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated CYP1A1 and CYP1B1 induction by 12-O-tetradecanoylphorbol-13-acetate: Role of transforming growth factor β and mitogen-activated protein kinases

Biochemical Pharmacology

Volumn 62, Issue 11, 2001, Pages 1449-1457

  Guo, Meng ^a   Joiakim, Aby ^a   Dudley, David T ^b   Reiners Jr, John J ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b PFIZER INC   (United States)

Author keywords

CYP1A1; MAP kinase; TCDD; TGF ; TPA

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; DIMETHYL SULFOXIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BREAST EPITHELIUM; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; EPITHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ARYL HYDROCARBON HYDROXYLASES; BENZAMIDES; CARCINOGENS; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITORS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE C; TETRACHLORODIBENZODIOXIN; TETRADECANOYLPHORBOL ACETATE; TRANS-ACTIVATION (GENETICS); TRANSFORMING GROWTH FACTOR BETA;

EID: 0035581272     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00801-2     Document Type: Article

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