Lipopolysaccharide modulation of dendritic cells is insufficient to mature dendritic cells to generate CTLs from naive polyclonal CD8+ T cells in vitro, whereas CD40 ligation is essential

Journal of Immunology

Volumn 167, Issue 11, 2001, Pages 6247-6255

  Kelleher, M ^a   Beverley, P C L ^a  

^a EDWARD JENNER INST FOR VACC RES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CD8 ANTIGEN; CHEMOKINE; CYTOKINE; ENDOTOXIN; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CELL INTERACTION; CELL MATURATION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DENDRITIC CELL; IMMUNOMODULATION; IN VITRO STUDY; MOUSE; NONHUMAN; POLYCLONAL ACTIVATION; PRIORITY JOURNAL;

EID: 0035575977     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.11.6247     Document Type: Article

References (52)

1. Immune responses in the absence of costimulation: Viruses know the trick
2. + CTL responses
3. CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection
4. + T cells cells mediate CD40-independent maturation of dendritic cells in vivo
5. + T-helper and a T-killer cell
6. Help for cytotoxic-T-cell responses is mediated by CD40 signaling
7. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
8. CD40 and CD154 in cell cell-mediated immunity
9. Cytotoxic T lymphocyte activation by cross-priming
10. The role of CD40/CD154 interactions in the priming differentiation, and effector function of helper and cytotoxic T cells
11. + T cell immunity
12. CD40-CD40Ligand interactions and their role in cytotoxic T lymphocyte priming and anti-tumor immunity
13. The role of CD40 in peripheral T cell tolerance and immunity
14. + cytotoxic T lymphocytes
15. + cytotoxic T lymphocyte priming capacity upon activation by T helper cell-independent or -dependent stimuli
16. CD40 ligand-dependent T cell activation: Requirement of B7-CD28 signaling through CD40
17. Activation of human dendritic cells through CD40 cross-linking
18. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
19. CD40L is important for induction of, but not response to, costimulatory activity: ICAM-1 as the second costimulatory molecule up-regulated by CD40L
20. High level of IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10
21. Localization, quantitation, and in situ detection of specific-peptide-MHC class I complexes using a monoclonal antibody
22. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macmphage colony-stimulating factor
23. Soluble antigen and CD40 triggering are sufficient to induce primary and memory cytotoxic T cells
24. A critical role for CD40-CD40 ligand interactions in amplification of the mucosal CD8 T cell response
25. TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor
26. + T cells in response to MIP-1α and MIP-1β
27. Interleukin-12: A cytokine at the interface of inflammation and immunity
28. Cellular and molecular mechanisms of the IL-12-induced increase in allospecific murine cytolytic T cell activity: Implications for the age-related decline in cytotoxic T lymphocyte
29. Interleukin 12 induces the differentiation of major histocompatibilty complex class I-primed cytotoxic T-lymphocyte precursors into allospecific cytotoxic effectors
30. Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo
31. Effects of IL-12 on the response and susceptibility to experimental viral infections
32. Uptake of microparticle-adsorbed protein antigen by bone marrow-derived dendritic cells results in up-regulation of interleukin-1α and interleukin-12 p40/p35 and triggers prolonged, efficient antigen presentation
33. Intedeukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-γ production by T helper 1 cells
34. Bacterial LPS stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells
35. + T cells
36. Regulation of T cell-dependent and -independent IL-12 production by the three Th2-type cytokines IL-10, IL-6, and IL-4
37. Preformed membrane-associated stores of interleukin (IL)-12 are a previously unrecognized source of bioactive IL-12 that is mobilized within minutes of contact with an intracellular parasite
38. IL-12-deficient mice are defective in IFN γ production and type 1 cytokine responses
39. Evidence for differential expression of CD45 isoforms by precursors for memory-dependent and independent cytotoxic responses: Human CD8 memory CTLp selectively express CD45RO (UCHLI)
40. + cytotoxic T lymphocytes by dendritic cells
41. Properties of purified T cell subsets. I. In vitro responses to class I vs. class II H-2 alloantigens
42. Immune fate decided by dendritic cell provocateurs
43. TRANCE, a tumor necrosis family member critical for CD40 ligand-independent T helper cell activation
44. TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells
45. TRANCE is a family member that regulates dendritic cell and osteoclast function
46. + T cells with homology to tumor necrosis factor
47. Ox-40 ligand: A potent costimulatory molecule for sustaining primary CD4 T cell responses
48. Potential role of 4-1BB in T cell activation: Comparison with the costimulatory molecule CD28
49. - T lymphocytes by 4-1BB ligand
50. + T cell proliferation and lead to amplification in vivo of cytotoxic T cell responses
51. Costimulation of antigen-specific CD4 T cells by 4-1BB ligands
52. Role of 4-1BB in immune response