Augmentation of apoptosis responses in p53-deficient L1210 cells by compounds directed at blocking NFkappaB activation

Anticancer Research

Volumn 21, Issue 6 A, 2001, Pages 3807-3811

  Cory, Ann H ^a   Cory, Joseph G ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Apoptosis; Leflunomide; NFkappaB; Parthenolide; Roscovitine

Indexed keywords

CASPASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEFLUNOMIDE; MESSENGER RNA; PARTHENOLIDE; PROTEIN P21; PROTEIN P53; ROSCOVITINE;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; IC 50; LEUKEMIA CELL; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASES; CELL CYCLE; GROWTH INHIBITORS; ISOXAZOLES; LEUKEMIA L1210; MICE; NF-KAPPA B; PURINES; SESQUITERPENES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035572018     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Effect of ionizing radiation on wild-type and mutant mouse leukemia L1210 cells
2. p53-independent anisomycin induced G1 arrest and apoptosis in L1210 cell lines
3. Altered sensitivity of deoxyadenosine-resistant mouse leukemia L1210 cells to various kinase inhibitors
4. Effect of doxorubicin on wild-type and deoxyadenosine-resistant mouse leukemia L1210 cells
5. Altered sensitivity of deoxyadenosine-resistant mouse leukemia L1210 cells to apoptosis by 7-hydroxystaurosporine
6. Enhanced roscovitine induced apoptosis is mediated by a caspase-3-like activity in deoxyadenosine-resistant mouse leukemia L 1210 cells
7. Apoptosis induced by inhibitors of nucleotide synthesis in deoxyadenosine-resistant leukemia L1210 cells that lack p53 expression
8. Increased sensitivity to sodium salicylate-induced apoptosis in drug-resistant leukemia L1210 cells
9. Anti-inflammatory effects of South American Tanacetum vulgare
10. The anti-inflammatory sesquiterpene lactone parthenolide inhibits NF-kappaB by targeting I kappaB kinase complex
11. Low concentrations of the fenefew component parthenolide inhibit in vitro growth of tumor lines in a cytostatic fashion
12. Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives
13. A 771726, the active metabolite of leflunomide directly inhibits the activity of cyclooxygenase-2 in vitro and in vivo in a substrate-sensitive manner
14. Immunosuppressive leflunomide metabolite (A 771726) blocks TNF-dependent nuclear factor-kappaB activation and gene expression
15. Selective resistance of L1210 cell lines to inhibitors directed at the subunits of ribonucleotide reductase
16. Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining
17. Altered steady-state levels of the messenger RNAs for c-myc and p53 in L1210 cell lines resistant to deoxyadenosine
18. Deoxyadenosine-resistant mouse leukemia L1210 cell lines with alterations in early response genes and p53