Apoptosis induced by inhibitors of nucleotide synthesis in deoxyadenosine-resistant leukemia L1210 cells that lack p53 expression

Anticancer Research

Volumn 20, Issue 6 B, 2000, Pages 4171-4178

  Cory, A H ^a   Hickerson, D H M ^a   Cory, J G ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Apoptosis; Deoxyadenosine resistant leukemia L1210 cells; Nucleotide synthesis inhibitors; P53

Indexed keywords

ANISOMYCIN; CASPASE 3; DEOXYADENOSINE; DEOXYADENOSINE TRIPHOSPHATE; DEOXYCYTIDINE; DEOXYGUANOSINE; DOXORUBICIN; METHOTREXATE; PROTEIN P53; RIBONUCLEOTIDE REDUCTASE; ROSCOVITINE; SPARFOSIC ACID; TIAZOFURIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; GROWTH INHIBITION; LEUKEMIA; LEUKEMOGENESIS; MOUSE; NONHUMAN; NUCLEOTIDE METABOLISM; PHENOTYPE; PRIORITY JOURNAL; RADIATION; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; ASPARTIC ACID; DEOXYADENOSINES; DEOXYGUANOSINE; DRUG RESISTANCE; GENES, P53; LEUKEMIA L1210; METHOTREXATE; MICE; MYCOPHENOLIC ACID; NUCLEOTIDES; PHOSPHONOACETIC ACID; RIBAVIRIN; RIBONUCLEOTIDE REDUCTASES;

EID: 0034480639     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Selective resistance of L1210 cell lines to inhibitors of ribonucleotide reductase
2. Multifactorial mechanisms of drug resistance in tumor cell populations selected for resistance to specific chemotherapeutic agents
3. Altered steady-state levels of the messenger RNAs for c-myc and p53 in L1210 cell lines resistant to deoxyadenosine
4. Effect of ionizing radiation on wild-type and mutant mouse leukemia L1210 cells
5. Effect of doxorubicin on wild-type and deoxyadenosine-resistant mouse leukemia L1210 cells
6. p53-independent anisomycin-induced G 1 arrest and apoptosis in L1210 cell lines
7. Altered sensitivity of deoxyadenosine-resistant mouse leukemia L1210 cells to various kinase inhibitors
8. A reversible, p53-dependent G0/G 1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
9. Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage
10. A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides
11. Effects of perturbations of pools of deoxyribonucleoside triphosphates on expression of ribonucleotide reductase, a G1/S transition state enzyme, in p53-mutated cells
12. Mammalian S-phase checkpoint integrity is dependent on transformation status and purine deoxyribonucleosides
13. p53 sends nucleotides to repair DNA
14. A ribonucleotide reductase gene involved in a p53-dependent cell- cycle checkpoint for DNA damage
15. Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture
16. Rapid flow cytometric analysis of mammalian cell cycle by propidium iodide staining
17. Cellular response in mouse leukemia L 1210 cells made resistant to deoxyadenosine
18. Quiescence in S-phase and G1 arrest induced by irradiation and/or hyperthermia in six human tumor cell lines of different p53 status
19. Preclinical cellular pharmacology of Ly231514 (MTA): A comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells
20. Biochemical differences among four inosinate dehydrogenase inhibitors, mycophenolic acid, ribovirin, tiazofurin, and selenazofurin, studied in mouse lymphoma cells
21. Modulation of IMP dehydrogenase activity and guanylate metabolism by tiazofurin (2-β-Dribofuranosylthiazole-4-carboxamide)
22. Tiazofurin-induced selective depression of NAD content in hepatoma 3924A
23. Inhibition of human caspase by peptide-based and macromolecular inhibitors
24. A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro
25. Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53