The HIV-1 envelope protein, gp120, causes neuronal apoptosis in the neocortex of the adult rat: A useful experimental model to study neuroaids

Functional Neurology

Volumn 16, Issue 4 SUPPL., 2001, Pages 31-38

  Corasaniti, M Tiziana ^a   Nisticò, Robert ^a   Costa, Alfredo ^a   Rotiroti, Domenicantonio ^a   Bagetta, Giacinto ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

Author keywords

AIDS dementia complex; Apoptosis; Excitotoxicity; IL 1 ; NGF; Nitric oxide

Indexed keywords

21 [4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]PREGNA 1,4,9(11) TRIENE 3,20 DIONE; ALPHA CHEMOKINE; AMINO ACID RECEPTOR AFFECTING AGENT; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; COAT PROTEIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DIZOCILPINE; GLUTAMATE RECEPTOR; GLYCOPROTEIN GP 120; INDOMETACIN; INTERLEUKIN 1BETA; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NERVE GROWTH FACTOR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN E2; VIRUS PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; BEHAVIOR DISORDER; BRAIN; BRAIN CORTEX; BRAIN TISSUE; CELL ACTIVATION; CELL LOSS; CELL NUCLEUS MEMBRANE; CHROMATIN; COGNITIVE DEFECT; CONFERENCE PAPER; DOSE RESPONSE; DRUG MECHANISM; DRUG POTENTIATION; DRUG RECEPTOR BINDING; ENDOPLASMIC RETICULUM; EXPERIMENTAL MODEL; HIPPOCAMPUS; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VIVO STUDY; INJECTION SITE; MICROGLIA; MITOCHONDRION; NEOCORTEX; NERVOUS SYSTEM INJURY; NICK END LABELING; NONHUMAN; PYRAMIDAL NERVE CELL; RAT; T LYMPHOCYTE; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE ANALYSIS AND ELECTRON MICROSCOPY; ANIMAL; DISEASE MODEL; HUMAN; NERVE CELL; PHYSIOLOGY; REVIEW;

AIDS DEMENTIA COMPLEX; ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; HIV ENVELOPE PROTEIN GP120; HUMANS; NEOCORTEX; NEURONS; RATS;

EID: 0035544916     PISSN: 03935264     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (46)

1. Neuronal loss in the frontal cortex in HIV infection
2. Transgenic models to assess the neuropathogenic potential of HIV-1 proteins and cytokines
3. Dementia associated with the acquired immunodeficiency syndrome
4. Neurotoxicity of HIV coat protein gp120, NMDA receptors, and protein kinase C: A study of with rat cerebellar granule cell cultures
5. Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice
6. The envelope glycoprotein of human immunodeficiency virus type one stimulates release of neurotoxins from monocytes
7. Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120
8. Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120
9. Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cylooxygenase
10. Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures
11. Nitric oxide synthases in mammals
12. Learning impairment following intracerebral administation of the HIV envelope protein gp120 or VIP antagonist
13. HIV envelope protein-induced neuronal damage and retardation of behavioural development in rat neonates
14. gp120, human immunodeficiency virus-1 coat protein, augments excitotoxic hippocampal injury in perinatal rats
15. Does HIV-1 glycoprotein GP120 produce neurodegeneration?
16. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
17. HIV-1 gp120 produces DNA fragmentation in the cerebral cortex of rat
18. Intracerebral injection of human immunodeficiency virus type 1 coat protein gp120 differentially affects the expression of nerve growth factor and nitric oxide synthase in the hippocampus of rat
19. The HIV-1 gp120 causes ultrastructural changes typical of apoptosis in the rat cerebral cortex
20. AIDS and the brain: Is there a chemokine connection?
21. Evidence that the HIV-1 coat protein gp120 causes neuronal apoptosis in the neocortex of rat via a mechanism involving CXCR4 chemokine receptor
22. Involvement of interleukin-1β in the mechanism of human immunodeficiency virus type 1 (HIV-1) recombinant protein gp120-induced apoptosis in the neocortex of rat
23. Interleukin-1 beta attenuates excitatory amino acid induced neurodegeneration in vitro: Involvement of nerve growth factor
24. Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions
25. Toward an understanding of the molecular mechanisms of physiological cell death
26. Kainate-induced apoptotic cell death in hippocampal neurons
27. Programmed cell death and the control of cell survival: Lessons from the nervous system
28. Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve
29. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide
30. Apoptosis induced by gp120 in the neocortex of rat involves enhanced expression of cylooxygenase type 2 (COX-2) and is prevented by NMDA receptor antagonists and by the 21-aminosteroid U-74389G
31. HIV-1 coat glycoprotein gp120 induces apoptosis in rat brain neocortex by deranging the arachidonate cascade in favour of prostanoids
32. Increased prostaglandin formation in rat brain following systemic application of kainic acid
33. Anticonvulsive effects of endogenous prostaglandins formed in brain of spontaneously convulsing gerbils
34. Accumulation of cyclooxygenase products of arachidonic acid metabolism in gerbil brain during reperfusion after bilateral common carotid artery occlusion
35. Cyclooxygenase-2 gene expression in neurons contributes to ischemic brain damage
36. Induction of cyclooxygenase-2 mRNA and protein following transient focal ischemia in the rat brain
37. Are cerebral prostanoids of astroglial origin?
38. HIV-1 gp120-induced apoptosis in the rat neocortex involves enhanced expression of cyclo-oxygenase type 2 (COX-2)
39. Expression of a mitogen-inducible cyclooxygenase in brain neurones: Regulation by synaptic activity and glucocorticoids
40. Glutamate neurotoxicity and diseases of the nervous system
41. Prostaglandins stimulate calcium-dependent glutamate release in astrocytes
42. Immunolocalization of HIV envelope gp120 in HIV encephalitis with dementia
43. Evidence of apoptotic cell death in HIV encephalitis
44. Evidence that increases of mitochondrial immunoreactive IL-1beta by HIV-1 gp120 implicate in situ cleavage of pro-IL-1beta in the neocortex of rat