Inhibition of carboxypeptidase a with β-lactone-bearing phenylalanine. Design, synthesis, and stereochemistry-dependent inhibition mode

Bulletin of the Korean Chemical Society

Volumn 22, Issue 11, 2001, Pages 1236-1242

  Lee, Mijoon ^a   Kim, Dong H ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

Lactone; Carboxypeptidase A; Inhibition stereochemistry; Inhibitor design strategy

Indexed keywords

3 (1' CARBOXY 2' PHENYL)ETHYLAMINO 2 OXETANONE; AMINO ACID; AROMATIC COMPOUND; CARBOXYPEPTIDASE A; LACTONE; OLIGOPEPTIDE; PHENYLALANINE; PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPETITIVE INHIBITION; DIASTEREOISOMER; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; INHIBITION KINETICS; STEREOCHEMISTRY; SYNTHESIS;

EID: 0035540625     PISSN: 02532964     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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