The role of enhancer A in the locus-specific transactivation of classical and nonclassical HLA class I genes by nuclear factor κB

Journal of Immunology

Volumn 161, Issue 5, 1998, Pages 2276-2283

  Gobin, Sam J P ^a   Keijsers, Vivian ^a   Van Zutphen, Marlijn ^a   Van Den Elsen, Peter J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; BINDING SITE; ENHANCER REGION; GENE LOCUS; HLA SYSTEM; HUMAN; HUMAN CELL; IMMUNOGENETICS; PRIORITY JOURNAL; TRANSACTIVATION; TRANSCRIPTION REGULATION;

BINDING SITES; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; GENES, MHC CLASS I; HLA ANTIGENS; HLA-A ANTIGENS; HLA-B ANTIGENS; HUMANS; NF-KAPPA B; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-REL; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED;

EID: 0032168354     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Singer, D. S., and J. E. Maguire. 1990. Regulation of the expression of class I MHC genes. Crit. Rev. Immunol. 10:235.
2. Le Bouteiller, P. 1994. HLA class I chromosomal region, genes, and products: facts and questions. Crit. Rev. Imnmnol. 14:89.
3. Germain, R. N. 1994. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76:287.
4. Le Bouteiller, P., and F. Lenfant. 1996. Antigen-presenting function(s) of the non-classical HLA-E, -F. -G class I molecules: the beginning of a story. Res. Immunol. 147:301.
5. Wood, G. W. 1994. Is restricted antigen presentation the explanation for fetal allograft survival? Immunol. Today 15:15.
6. Carosella, E. D., J. Dausset, and M. Kirszenbaum. 1996. HLA-G revisited. Immunol. Today 17:407.
7. Girdlestone, J. 1996. Transcriptional regulation of MHC class 1 genes. Eur. J. Immunogen. 23:393.
8. Dey, A., A. M. Thornton, M. Lonergan, S. M. Weissman, J. W. Chamberlain, and K. Ozato. 1992. Occupancy of upstream regulatory sites in vivo coincides with major histocompatibility complex class I gene expression in mouse tissues. Mol. Cell. Biol. 12:3590.
9. Gobin, S. J. P., A. Peijnenburg, V. Keijsers, and P. J. van den Elsen. 1997. Site α is crucial for two routes of IFN-γ-induced MHC class I transactivation: the ISRE-mediated route and a novel pathway involving CIITA. Immunity 6:601.
10. Martin, B. K., K.-C. Chin, J. C. Olsen, C. A. Skinner, A. Dey, K. Ozato, and J. P.-Y. Ting. 1997. Induction of MHC class I expression by the MHC class II transactivator CIITA. Immunity 6:591.
11. Sen, R., and D. Baltimore. 1986. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46:705.
12. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141.
13. Miyamoto, S., and I. M. Verma. 1995. Rel/NF-κB/IκB story. Adv. Cancer Res. 66:255.
14. Urban, M. B., and P. A. Baeuerle. 1990. The 65-kD subunit of NF-κB is a receptor for IκB and a modulator of DNA-binding specificity. Genes Dev. 4:1975.
15. Urban, B. M., R. Schreck, and P. A. Baeuerle. 1991. NF-κB contacts DNA by a heterodimer of the p50 and p65 subunit. EMBO J. 10:1817.
16. Thanos, D., and T. Maniatis. 1995. NF-κB: a lesson in family values. Cell 80:539.
17. Finco, T. S., and A. S. Baldwin. 1995. Mechanistic aspects of NF-κB regulation: the emerging role of phosphorylation and proteolysis. Immunity 3:263.
18. Verma, I. M., J. K. Stevenson, E. M. Schwartz, D. Van Antwerp, and S. Miyamoto. 1995. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9:2723.
19. Fujita, T., G. P. Nolan, S. Ghosh, and D. Baltimore. 1992. Independent modes of transcriptional activation by the p50 and p65 subunits of NF-κB. Genes Dev. 6:775.
20. Cereb, N., and S. Y. Yang. 1994. The regulatory complex of HLA class I promoter exhibits locus-specific conservation with limited allelic variation. J. Immunol. 152:3873.
21. Mansky, P., W. M. Brown, J.-H. Park, J. W. Choi, and S. Y. Yang. 1994. The second κB element, κB2, of the HLA-A class I regulatory complex is an essential part of the promoter. J. Immunol. 153:5082.
22. Gorman, C., R. Padmanabhan, B. H. Howard. 1983. High efficiency DNA-mediated transformation of primate cells. Science 221:551.
23. Chen, C., and H. Okayama. 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7:2745.
24. Thanos, D., and T. Maniatis. 1992. The high mobility group protein HMG I(Y) is required for NF-κB-dependent induction of the human IFNβ gene. Cell 71:777.
25. Menon, S. D., S., Qin, G. R. Guy, and Y. H. Tan. 1995. Differential induction of nuclear NF-κB by protein phophatase inhibitors in primary and transformed human cells. J. Biol. Chem. 268:26805.
26. Wang, Y., J. J. Zhang, W. Dai, K. Y. Lei, and J. W. Pike (1997). Dexamethasone potently enhances phorbol ester-induced IL-1β gene expression and nuclear factor NF-κB activation. J. Immunol. 159:534.
27. Letovsky, J., and W. S. Dynan. 1989. Measurement of transcription factor Sp1 to a single GC box recognition sequence. Nucleic Acids Res. 17:2639.
28. Soong, T. W., and K. M. Hui. 1992. Locus-specific transcriptional control of HLA genes. J. Immunol. 149:2008.
29. Girdlestone, J., M. Isamat, D. Gewert, and C. Milstein. 1993. Transcriptional regulation of HLA-A and -B: differential binding of members of the Rel and IRF families of transcription factors. Proc. Natl. Acad. Sci. USA 90:11568.
30. Giuliani, C., M. Saji, G. Napolitano, L. A. Palmer, S.-I. Taniguchi, M. Shong, D. S. Singer, and L. D. Kohn. 1995. Hormonal modulation of major histocompatibility complex class I gene expression involves an enhancer A-binding complex consisting of Fra-2 and the p50 subunit of NF-κB. J. Biol. Chem. 270:11453.
31. Urban, M. B., and P. A. Baeuerle. 1991. The role of p50 and p65 subunits of NF-κB in the recognition of cognate sequences. New Biologist 3:278.
32. Zabel, J., R. Schreck, and P. A. Baeuerle. 1991. DNA binding of purified transcription factor NF-κB. J. Biol. Chem. 266:252.
33. Kunsch, C., S. M. Ruben, and C. A. Rosen. 1992. Selection of optimal κB/Rel DNA-binding motifs: interaction of both subunits of NF-κB with DNA is required for transcriptional activation. Mol. Cell. Biol. 12:4412.
34. Matthews, J. R., J. Nicholson, E. Jaffray, S. M. Kelly, N. C. Price, and R. T. Hay. 1994. Conformational changes induced by DNA binding of NF-κB. Nucleic Acids Res. 23:3393.
35. Park, J. H., H. W. Lee, K. L. Fleischhauer, C. G. Kim, M. Sheffery, and S. Y. Yang. 1993. DNA-binding proteins for transcription enhancing region of HLA class I gene. Tissue Antigens 42:78.
36. Johnson, D. R., and J. S. Pober. 1994. HLA class I heavy-chain gene promoter elements mediating synergy between tumor necrosis factor and interferons. Mol. Cell. Biol. 14:1322.
37. Yie, J., S. Liang, M. Merika, and D. Thanos. 1997. Intra- and intermolecular cooperative binding of high-mobility-group protein I(Y) to the β-interferon promoter. Mol. Cell. Biol. 17:3649.
38. Morris, J. F., R. Hromas, and F. J. Rauscher III. 1994. Characterization of the DNA-binding properties of the myeloid zinc finger protein MZF1: Two independent DNA-binding domains recognize two DNA consensus sequences with a common G-rich core. Mol. Cell. Biol. 14:1786.
39. Blanchet, O., C. Gazin, M. L'Haridon, Z. Tatari, L. Degos, F. Sigaux, and P. Paul. 1994. Multiple nuclear factors bind to novel positive and negative regulatory elements upstream of the human MHC class I gene HLA-A11. Int. Immunol. 6:1485.
40. L'Haridon, M., P. Paul, J.-G. Xerri, H. Dastot, C. Dolliger, M. Schmid, N. de Angelis, L. Grollet, F. Sigaux, L. Degos, and C. Gazin. 1996. Transcriptional regulation of the MHC class I HLA-A11 promoter by the zinc finger protein ZFX. Nucleic Acids Res. 24:1928.
41. Lernbecher, T., U. Müller, and T. Wirth. 1993. Distinct NF-κB/Rel transcription factors are responsible for tissue-specific and inducible gene activation. Nature 365:767.
42. Kieran, M., V. Blank, F. Logeat, J. Vanderkerckhove, F. Lottspeich, O. Le Bail, M. B. Urban, P. Kourilsky, P. A. Baeuerle, and A. Israel. 1990. The DNA binding subunit of NF-κB is identical to κBF1 and homologous to the Rel oncogene product. Cell 62:1007.
43. Segars, J. H., T. Nagata, V. Bours, J. A. Medin, G. Franzoso, J. C. G. Blanco, P. D. Drew, K. G. Becker, J. An, T. Tang, D. A. Stephany, B. Neel, U. Siebenlist, and K. Ozato. 1993. Retinoic acid induction of major histocompatibility complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-κB (p50-p65) and retinoic acid receptor β-retinoid X receptor β heterodimers. Mol. Cell. Biol. 13:6157.
44. Pettersson, M., and W. Schaffner. 1990. Synergistic activation of transcription by multiple binding sites for NF-κB even in absence of co-operative factor binding 7 to DNA. J. Mol. Biol. 214:373.
45. Israël, A., O. Le Bail, D. Hatat, J. Piette, M. Kieran, F. Logeat, D. Wallach, M. Fellous, and P. Kourilsky. 1989. TNF stimulates expression of mouse MHC class I genes by inducing an NF-κB-like enhancer binding activity which displaces constitutive factors. EMBO J. 8:3793.
46. Perkins, N. D., N. L. Edwards, C. S. Duckett, A. B. Agranoff, R. M. Schmid, and G. J. Nabel. 1993. A cooperative interaction between NF-κB and Sp1 is required for HIV-1 enhancer activation. EMBO J. 12:3551.
47. Pazin, M. J., P. L. Sheridan, K. Cannon, Z. Cao, J. G. Keck, J. T. Kadonaga, and K. A. Jones. 1996. NF-κB-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitro. Genes Dev. 10:37.
48. Kadonaga, J. T., K. A. Jones, and R. Tjian. 1986. Promoter-specific activation of RNA polymerase II transcription by Sp1. Trends Biochem. Sci. 11:20.
49. Wright, K. L., L. C. White, A. Kelly, S. Beck, J. Trowsdale and J.P.-Y. Ting. 1995. Coordinate regulation of the human TAP1 and LMP2 genes from a shared bidirectional promoter. J. Exp. Med. 181:1459.
50. Min, W., J. S. Pober, and D. R. Johnson. 1996. Kinetically coordinated induction of TAP1 and HLA class I by IFN-γ: the rapid induction of TAP by IFN-γ is mediated by stat1α. J. Immunol. 156:3174.