Introduction of exogenous class II Trans-activator in MHC class II-deficient ABI fibroblasts results in incomplete rescue of MHC class II antigen expression

Journal of Immunology

Volumn 159, Issue 6, 1997, Pages 2720-2727

  Peijnenburg, Ad ^a   Gobin, Sam J P ^a   Van Eggermond, Marja C J A ^a   Godthelp, Barbara C ^a   Van Graafeiland, Niels ^a   Van Den Elsen, Peter J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 2; MHC CLASS II TRANSACTIVATOR PROTEIN; NUCLEAR PROTEIN; TRANSACTIVATOR PROTEIN;

ARTICLE; BIOSYNTHESIS; CELL LINE; FIBROBLAST; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE TRANSFER; GENETICS; HUMAN; IMMUNOLOGY;

CELL LINE, TRANSFORMED; FIBROBLASTS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; NUCLEAR PROTEINS; TRANS-ACTIVATORS;

EID: 0031571884     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Benoist, C., and D. Mathis. 1990. Regulation of major histocompatibility complex class-II genes: X, Y, and other letters of the alphabet. Annu. Rev. Immunol. 8:681.
2. Glimcher, L. H., and C. J. Kara. 1992. Sequences and factors: a guide to MHC class II transcription. Annu. Rev. Immunol. 10:13.
3. Ting, J. P. -Y., and A. S. Baldwin. 1993. Regulation of MHC gene expression. Curr. Opin. Immunol. 5:8.
4. Mach, B., V. Steimle, and W. Reith. 1994. MHC class II-deficient combined immunodeficiency: a disease of gene regulation. Immunol. Rev. 138:207.
5. Reith, W., V. Steimle, and B. Mach. 1995. Molecular defects in the bare lymphocyte syndrome and regulation of MHC class II genes. Immunol. Today 16:539.
6. Mach, B., V. Steimle, E. Martinez-Soria, and W. Reith. 1996. Regulation of MHC class II genes: lessons from a disease. Annu. Rev. Immunol. 14:301.
7. Bénichou, B., and J. L. Strominger. 1991. Class II-antigen-negative patient and mutant B-cell lines represent at least three, and probably four, distinct genetic defects defined by complementation analysis. Proc. Natl. Acad. Sci. USA 88:4285.
8. Hume, C. R., L. A. Shookster, N. Collins, R. O'Reilly, and J. Lee. 1989. Bare lymphocyte syndrome: altered HLA class II expression in B-cell lines derived from two patients. Hum. Immunol. 25:1.
9. Yang, Z., R. S. Accolla, D. Pious, B. J. M. Zegers, and J. L. Strominger. 1988. Two distinct genetic loci regulating class II gene expression are defective in human mutant and patient cell lines. EMBO J. 7:1965.
10. Peijnenburg, A., B. Godthelp, A. van Boxel-Dezaire, and P. J. van den Elsen. 1995. Definition of a novel complementation group in MHC class II deficiency. Immunogenetics 41:287.
11. Steimle, V., L. A. Otten, M. Zufferey, and B. Mach. 1993. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). Cell 75:135.
12. Steimle, V., B. Durand, E. Barras, M. Zufferey, M. R. Hadam, B. Mach, and W. Reith. 1995. A novel DNA binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome). Genes Dev. 9:1021.
13. Durand, B., M. Kobr, W. Reith, and B. Mach. 1994. Functional complementation of MHC class II regulatory mutants by the purified X box binding protein RFX. Mol. Cell. Biol. 14:6839.
14. Steimle, V., C.-A. Siegrist, A. Mottet, B. Lisowska-Grospierre, and B. Mach. 1994. Regulation of MHC class II expression by interferon-γ mediated by the transactivator gene CIITA. Science 265:106.