Radical approaches to probe protein structure, folding, and interactions by mass spectrometry

Mass Spectrometry Reviews

Volumn 20, Issue 6, 2001, Pages 388-401

  Maleknia, Simin D ^a,c   Downard, Kevin M ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF SYDNEY   (Australia)

^c Sciformatics   (Australia)

Author keywords

Protein folding; Protein structure; Radical

Indexed keywords

AMINO ACIDS; MASS SPECTROMETRY; MOLECULAR DYNAMICS; OXIDATION; REACTION KINETICS; STRUCTURE (COMPOSITION); SYNCHROTRON RADIATION; UREA;

ACTIN; APOMYOGLOBIN; DISCHARGE SOURCES; GELSOLIN; PROTEIN FOLDING;

PROTEINS;

DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; FREE RADICAL; PROTEIN;

ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; MASS SPECTROMETRY; METHODOLOGY; PROTEIN CONFORMATION; PROTEIN FOLDING; REVIEW;

ANIMALS; FREE RADICALS; HUMANS; INDICATORS AND REAGENTS; MASS SPECTROMETRY; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEINS;

EID: 0035497782     PISSN: 02777037     EISSN: None     Source Type: Journal    
DOI: 10.1002/mas.10013     Document Type: Article

References (73)

1. Pulse and gamma-radiolysis of aqueous solutions of tryptophan
2. Glow discharge mass spectrometry
3. Elemental and organometallic analyses of soil using glow discharge mass spectrometry and gas chromatography/mass spectrometry
4. The action of hydrogen peroxide on keratin
5. Structure and function of gelsolin
6. Radiation chemistry of the liquid state: (I) water and homogeneous aqueous solutions
7. Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals in aqueous solution
8. Hydrogen peroxide mediates the oxidative inactivation of enzymes following the switch from anaerobic to aerobic metabolism in klebsiella pneumoniae
9. UV resonance raman determination of protein acid denaturation: Selective unfolding of helical segments of horse myoglobin
10. The oxidation of amido-acids with the production of substances of biological importance
11. The oxidation of leucine, α-amino-isovaleric acid and α-amino-valeric acid with hydrogen peroxide
12. Note on the oxidation of glutamic acid by means of hydrogen peroxide
13. The fate of inactive tyrosine in the animal body together with observations upon the detection of tyrosine and its derivatives in the urine
14. Behaviour of hypochlorites on IV injection and their action on blood serum
15. Oxidations and reductions in the animal body
16. Radical-mediated protein oxidation: From chemistry to medicine
17. Histidine and proline are important sites of free-radical damage to proteins
18. Radiation induced conversion of phenylalanine to tyrosine
19. Advances in protein analysis and sequencing by mass spectrometry
20. Fast kinetics and mechanisms in protein folding
21. Oxidative and reductive cleavage of proteins
22. Determination of protein-protein interactions by matrix-assisted laser desorption/ionization mass spectrometry
23. 2O system
24. Oxidation of tartaric acid in the presence of iron
25. The oxidation of polyhydric alcohols in the presence of iron
26. Action of penetrating radium rays upon inorganic colloids and bio-colloids
27. Reaction mechanisms in the radiolysis of peptides
28. Synchrotron X-ray footprinting of gelsolin-actin complex
29. n
30. Observations on the velocity of the photo-oxidation of proteins and amino acids
31. Mapping protein domains involved in macromolecular interactions: A novel protein footprinting approach
32. Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing
33. Hydroperoxide-mediated fragmentation of proteins
34. The effect of radioactive radiations and X-rays on enzymes. I. The effect of radiation from radium emanation on solutions of trypsin
35. The effect of radioactive radiations and X-rays on enzymes. II. The effect of radiation from radium emanation on pepsin in solution
36. Formation of ions in glow discharge mass spectrometry ion sources
37. A stable solid that generates hydroxyl radical upon dissociation in aqueous solutions: Reactions with proteins and nucleic acids
38. Antigenic surveillance of the influenza virus by mass spectrometry
39. Preservation and detection of specific antibody-peptide complexes by matrix-assisted laser desorption ionization mass spectrometry
40. Primary products in radiation chemistry
41. Radiation chemical reactions in aqueous solutions of methionine and its peptides
42. Structure and stability of a second molten globule intermediate in the apomyoglobin folding pathway
43. Studying noncovalent protein complexes by electrospray ionization mass spectrometry
44. Millisecond radiolytic modification of peptides by synchrotron X-rays identified by mass spectrometry
45. Electrospray-assisted modification of proteins. A radical probe of protein structure
46. Synchrotron x-ray footprinting of protein antigens and their complexes
47. Electrospray generated oxygenated radicals to probe protein structure
48. Unfolding of apomyoglobin helices by synchrotron radiolysis and mass spectrometry
49. Determination of macromolecular folding and structure by synchrotron x-ray radiolysis techniques
50. Identifying hydrophobic core proteins by synchrotron x-ray radiolysis and mass spectrometry
51. Hydroxyl radical probe of the surface of lysozyme by synchrotron radiolysis and mass spectrometry
52. Rate constants for the reactions of OH radicals with the enzyme proteins as determined by the p-nitrosodimethylaniline method
53. Structure of gelsolin segment 1-actin complex and the mechanism of filament severing
54. Matrix-assisted laser desorption-ionization time-of-flight mass spectrometry in the subunit stoichiometry study of high-mass non-covalent complexes
55. Oxidative inactivation of glutamine synthetase subunits
56. Using hydroxyl radical to probe DNA structure
57. The interpretation of protein structures: Total volume, group volume distributions and packing density
58. Solvent accessible surface area and excluded volume in proteins. Analytical equations for overlapping spheres and implications for the hydrophobic effect
59. Isotopic ratio measurements using glow discharge mass spectrometry
60. Unfolding free energy changes determined by the linear extrapolation method: 1-unfolding of phenylmethanesulfonyl alpha-chymotrypsin using different denaturants
61. The role of protein-solvent interactions in protein unfolding
62. A refined solution structure of hen lysozyme determined using residual dipolar coupling data
63. Time-resolved synchrotron x-ray footprinting, a new approach to the study of nucleic acid structure and function: Application to protein-DNA interactions and RNA folding
64. Following the folding of RNA with time-resolved synchrotron x-ray footprinting
65. Reaction of hydroxyl radicals with phenylalanine in neutral aqueous solution
66. Oxidative demethoxylation of methoxyated phenols and hydroxybenzoic acid by the HO• radical. An in situ electron spin resonance, conductometric, pulse radiolysis and product analysis study
67. Protein metal-binding sites
68. Rays of positive electricity and their application to chemical analysis
69. Selective oxidation of the imidazole ring in histidine residues by the ascorbic acid-copper ion system
70. 2-oxo-histidine as a novel biological marker for oxidatively modified proteins
71. Free-radical reactions involving thiols and disulphides
72. Fragmentation of proteins by free radicals and its effect on their susceptibility to enzymic hydrolysis