Ten years of preoperative chemoradiation for extraperitoneal T3 rectal cancer: Acute toxicity, tumor response, and sphincter preservation in three consecutive studies

International Journal of Radiation Oncology Biology Physics

Volumn 51, Issue 2, 2001, Pages 371-383

  Valentini, Vincenzo ^a   Coco, Claudio ^a   Cellini, Numa ^a   Picciocchi, Aurelio ^a   Fares, M Claudia ^a   Rosetto, Maria Elena ^a   Mantini, Giovanna ^a   Morganti, Alessio G ^a   Barbaro, Brunella ^b   Cogliandolo, Santa ^a   Nuzzo, Gennaro ^a   Tedesco, Manfredo ^c   Ambesi Impiombato, Fabrizio ^c   Cosimelli, Maurizio ^c   Rotman, Marvin ^d  

^a CATHOLIC UNIVERSITY   (Italy)

^b Istituto di Radiologia di Universita Cattolica del Sacro Cuore di Roma   (Italy)

^c REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^d SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

5 FU; Combined modality therapy; Infusional chemotherapy; Preoperative radiotherapy; Rectal neoplasms; Sphincter saving procedure

Indexed keywords

SPHINCTER PRESERVATION;

CHEMOTHERAPY; PATHOLOGY; PATIENT TREATMENT; SURGERY; TUMORS;

RADIOTHERAPY;

CISPLATIN; FLUOROURACIL; MITOMYCIN C;

ACUTE TOXICITY; ADULT; AGED; ANUS SPHINCTER; ARTICLE; CANCER RADIOTHERAPY; CLINICAL TRIAL; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIMODALITY CANCER THERAPY; PRIORITY JOURNAL; RADIATION DOSE; RECTUM CANCER; WORLD HEALTH ORGANIZATION;

ADULT; AGED; AGED, 80 AND OVER; ANAL CANAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COMBINED MODALITY THERAPY; DIARRHEA; FEMALE; FLUOROURACIL; HUMANS; LEUKOPENIA; MALE; MIDDLE AGED; MITOMYCIN; NEOPLASM STAGING; PATIENT SELECTION; PROSPECTIVE STUDIES; RADIOTHERAPY DOSAGE; RECTAL NEOPLASMS;

EID: 0035479071     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(01)01618-2     Document Type: Article

References (44)

1. Preoperative chemotherapy and radiation therapy for locally advanced primary and recurrent rectal carcinoma. A report of surgical morbidity
2. Preoperative infusional chemoradiation therapy for stage T3 rectal cancer
3. Preoperative radiation and chemotherapy in the treatment of adenocarcinoma of the rectum
4. Preliminary results of preoperative 5-Fluorouracil, low-dose Leucovorin and concurrent radiation therapy for clinically resectable T3 rectal cancer
5. Preoperative chemoradiation for extraperitoneal T3 rectal cancer; Acute toxicity, tumor response, sphincter preservation
6. Preoperative chemoradiation with cisplatin and 5-fluorouracil for extraperitoneal T3 rectal cancer; Acute toxicity, tumor response, sphincter preservation
7. Preoperative radiochemotherapy in rectal cancer; Long-term results of a phase II trial
8. Diagnostic and therapeutic integration in rectal cancer. Preliminary notes
9. Graphic representation of pain
10. Phase I/II trial of pre-operative radiation therapy, and coloanal anastomosis in distal invasive resectable rectal cancer
11. Control of small bowel motion and set up errors during box pelvic treatment, using the new 'up down table' device
12. Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathologic correlations
13. Overview
14. Reporting results of cancer treatment
15. Sampling behavior of tests for correlation in two-way contingency tables
16. 2 tests
17. Initial molecular characterization of human dihydropyrimidine dehydrogenase deficency; a pharmacogenetic syndrome predisposing to severe 5-fluorouracil toxicity
18. Combined effect of x-radiation and 5-FU on survival of transplanted leukemic cells
19. Theoretical basis and clinical applications of 5-fluorouracil as a radiosensitizer-an overview
20. Pharmacologic requirements for obtaining sensitization of human tumor cells in vitro to combined 5-fluorouracil or ftorafur and x rays
21. Phase I and pharmacologic study of 72-hour infused 5-fluorouracil and hyperfractionated cyclical radiation
22. The development of chemotherapy drugs as radiosensitizers; An overview
23. Time-dose relationship for 5-fluorouracil cytotoxicity against human epithelial cancer cells in vitro
24. Cisplatin as a radiosensitizer in clinical practice; A pilot study
25. Low-dose continuous infusion cisplatin combined with external beam irradiation for advanced colorectal adenocarcinoma and unresectable non-small-cell lung carcinoma
26. Radiosensitization of hypoxic tumor cells by cis- and trans-dichlorodiammineplatinum (II)
27. The interaction of cisplatinum and radiation on RIF-1 tumours cells in vitro
28. Combined treatment of radiation and cis-diamminochloroplatinum (II); A review of experimental and clinical data
29. Effect of cis-diamminochloroplatinum (II) and x-rays on mammalian cell survival
30. Der Effekt einer kombinierten Behandlung mit Cisplatin und Bestrahlung auf das Uberleben von Chinesischen Hamsterzellen
31. Studies on cis-diamminochloroplatinum (II) as a radiosensitizier
32. Cisplatin (P) as radiopotentiator. Dose and time intensity limitations of its administration by continuous intravenous infusion (CI)
33. Improved survival with neoadjuvant therapy and resection for adenocarcinoma of the esophagus
34. A comparison of multimodal therapy and surgery for esophageal adenocarcinoma
35. Lymphatic spread and its prognostic value in patients with rectal cancer
36. The accuracy of transrectal ultrasound in predicting the pathological stage of low-lying rectal cancer after preoperative chemoradiation therapy
37. Prognostic implications of response to preoperative infusional chemoradiation in locally advanced rectal cancer
38. Preoperative radiotherapy (RT) for rectal cancer: Predictive factors of tumor downstaging and residual tumor cell density (RTCD): Prognostic implications
39. Low rectal cancer; Impact of radiation and chemotherapy on surgical treatment
40. Prognostic implications of downstaging following preoperative radiation therapy for operable T3-T4 rectal cancer