The spindle kinesin-like protein HsEg5 is an autoantigen in systemic lupus erythematosus

Arthritis and Rheumatism

Volumn 39, Issue 10, 1996, Pages 1635-1642

  Whitehead, Clark M ^a   Winkfein, Robert J ^a   Fritzler, Marvin J ^a   Rattner, J B ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; KINESIN;

ANTIBODY DETECTION; ARTICLE; AUTOIMMUNITY; BASE PAIRING; CELL DIVISION; DNA LIBRARY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOPRECIPITATION; MITOSIS SPINDLE; PRIORITY JOURNAL; PROPHASE; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0029770674     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780391005     Document Type: Article

References (27)

1. Rattner JB, Wang T, Mack G, Martin L, Fritzler MJ: MSA-35: a protein identified by human autoantibodies that colocalizes with microtubules. Biochem Cell Biol 70:1115-1122, 1992
2. Fritzler MJ, Tan EM: Antinuclear antibodies and the connective tissue diseases. In, Laboratory Diagnostic Procedures in the Rheumatic Diseases. Edited by AS Cohen, New York, Grune and Stratton, 1985
3. Webb J, Maule P, Wells JV: Antibody to mitotic spindle apparatus (letter). J Rheumatol 12:6231, 985
4. McCarty GA, Valencia DW, Fritzler MJ, Barada FA: A unique antinuclear antibody staining only the mitotic spindle apparatus (letter). New Engl J Med 305:703, 1981
5. Auer-Grumbach P, Achleitner B: Epidemiology and clinical associations of NuMA (nuclear mitotic apparatus protein) autoantibodies. J Rheumatol 21:1779-1781, 1994
6. Yeo JP, Forer A, Toh B: A homologue of the human regulator of mitotic spindle assembly protein (RMSA-1) is present in crane fly and is associated with meiotic chromosomes. J Cell Sci 107:1845-1851, 1994
7. Lyderson B, Pettijohn D: Human-specific nuclear protein that associates with the polar region of the mitotic apparatus: distribution in a human/hamster hybrid cell. Cell 22:489-499, 1980
8. Cleveland DW: NuMA involvement in nuclear structure, spindle assembly and nuclear reformation. Trends Cell Biol 5:60-64, 1995
9. Compton DA, Cleveland DW: NuMA, a nuclear protein involved in mitosis and nuclear reformation. Curr Opin Cell Biol 6:343-346, 1994
10. Chan EKL, Andrade LEC: Antinuclear antibodies in Sjögren's syndrome. Rheum Dis Clin North Am 18:551-570, 1992
11. cdc2 regulates spindle association of human Eg5, a kinesin-related motor protein essential for bipolar spindle formation in vivo. Cell 83:1159-1169, 1995
12. Fox RI, Robinson CA, Curd JG, Kozin F, Howell FV: Sjögren's syndrome: proposed criteria for classification. Arthritis Rheum 29:577-585, 1986
13. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ: The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25:1271-1277, 1982
14. Sanger F, Nicklen S, Coulson AR: DNA sequencing with chain terminating inhibitors. Proc Natl Acad Sci U S A 74:5463-5467, 1977
15. Devereux J, Haeberli P, Smithies O: A comprehensive set of sequence analysis for the VAX. Nucleic Acids Res 12:387-395, 1984
16. Altschul SF, Gish WM, Myers EW, Lipman DJ: Basic local alignment search tool. J Mol Biol 215:403-410, 1990
17. LeGueliec R, Paric J, Couturier A, Roghi C, Philippe M: Cloning by differential screening of a Xenopus cDNA that encodes a kinesin-related protein. Mol Cell Biol 11:3395-3398, 1991
18. Yang CH, Lalmbie EJ, Snyder M: NuMA: an unusually long coiled-coil related protein in the mammalian nucleus. J Cell Biol 116:1303-1317, 1992
19. Pollard KM, Chan EKL, Grant BJ, Sullivan KF, Tan EM, Glass CA: In vitro posttranslational modification of lamin B cloned from a human T-cell line. Mol Cell Biol 10:2164-2175, 1990
20. Cunningham MW, Antone SM, Gulizia JM, McManus BA, Gauntt CJ: Helical coiled-coil molecules: a role in autoimmunity against the heart. Clin Immunol Immunopathol 68:118-123, 1993
21. Chan EKL, Hamel JC, Buyon JP, Tan EM: Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen. J Clin Invest 87:68-76, 1991
22. Yaneva M, Wen J, Ayala A, Cook R: cDNA-derived amino acid sequence motifs of the 86-kDa subunit of the Ku antigen. J Biol Chem 270:13407-13411, 1989
23. Fritzler MJ, Lung C, Hamel JC, Griffith K, Chan EKL: Molecular characterization of golgin-245: a novel Golgi complex protein containing a granin signature. J Biol Chem 270:31262-31268, 1995
24. Earnshaw WC, Rothfield NF: Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma. Chromosoma 91:313-322, 1985
25. d/CENP-F in disorders associated with cell proliferation. J Autoimmun 8:575-586, 1995
26. Rattner JB, Rees J, Whitehead CM, Casiano CA, Tan EM, Humbel RL, Fritzler MJ: Patients with autoantibodies to a recombinant centromere protein CENP-F have a high frequency of malignancy. Submitted for publication
27. Andrade LEC, Chan EKL, Peebles CL, Tan EM: Two major autoantigen-antibody systems of the mitotic spindle apparatus. Arthritis Rheum 39:1643-1653, 1996