Apolipoprotein E immunoreactivity in neurons and neurofibrillary degeneration of aged non-demented and Alzheimer's disease patients

Microscopy Research and Technique

Volumn 55, Issue 1, 2001, Pages 48-58

  Gómez Ramos, Pilar ^a   Mufson, Elliott J ^b   Morán, M Asunción ^a  

^a AUTONOMOUS UNIVERSITY OF MADRID   (Spain)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Phosphorylated tau; Pretangle neuron; Tangle

Indexed keywords

ELECTRON MICROSCOPES; ELECTRON MICROSCOPY; LIPOPROTEINS; NEURODEGENERATIVE DISEASES;

ALZHEIMERS DISEASE; APOLIPOPROTEIN E; CORTEXES; EXTRACELLULAR; IMMUNOLABELLING; IMMUNOREACTIVITIES; PHOSPHORYLATED TAU; PRETANGLE NEURON; RISK FACTORS; TANGLE;

NEURONS;

AMYLOID; ANTIBODY; APOLIPOPROTEIN E; APOLIPOPROTEIN E ANTIBODY; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY AT 8; TAU PROTEIN; UNCLASSIFIED DRUG;

AGED; ALZHEIMER DISEASE; ANTIBODY LABELING; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; DEMENTIA; ELECTRON MICROSCOPY; ENTORHINAL CORTEX; GENOTYPE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; INSULA; MICROSCOPY; NERVE CELL; NEURITE; NEUROFIBRILLARY TANGLE; NEUROPIL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RISK FACTOR; SENILE PLAQUE;

EID: 0035478026     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jemt.1155     Document Type: Article

References (42)

1. Artiga MJ, Bullido MJ, Frank A, Sastre I, Recuero M, Garcia MA, Lendon CL, Han SW, Morris JC, Vázquez J, Goate A, Valdivieso F. 1998. Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene. Hum Mol Genet 7:1887-1892.
2. Bancher C, Brunner C, Lassmann H, Budka H, Jellinger K, Wiche G, Seitelberger F, Grundke-Iqbal I, Iqbal K, Wisniewski HM. 1989. Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease. Brain Res 477:90-99.
3. Bancher C, Egensperger R, Kösel S, Jellinger K, Graeber MB. 1997. Low prevalence of apolipoprotein E e4 allele in the neurofibrillary tangle predominant form of senile dementia. Acta Neuropathol 94:403-309.
4. Barger SW, Mattson MP. 1997. Isoform-specific modulation by apolipoprotein E of the activities of secreted β-amyloid precursor protein. J Neurochem 69:60-67.
5. Benzing WC, Mufson EJ. 1995. Apolipoprotein E immunoreactivity within neurofibrillary tangles: relationship to tau and PHF in Alzheimer's disease. Exp Neurol 132:162-171.
6. Biernat J, Mandelkow EM, Schröter C, Lichtenberg-Kraag B, Steiner B, Berling B, Meyer H, Mercken, M, Vandermeeren A, Goedert M, Mandelkow E. 1992. The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region. EMBO J 11:1593-1597.
7. Braak H, Braak E. 1991. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 82:239-259.
8. Braak H, Braak E. 1995. Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol Aging 16:271-284.
9. Braak E, Braak H, Mandelkow EM. 1994. A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropathol 87:554-567.
10. Bullido MJ, Artiga MJ, Recuero M, Sastre I, Garcia MA, Aldudo J, Lendon C, Han SW, Morris JC, Frank A, Vazquez J, Goate A, Valdivieso F. 1998. A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia. Nature Genet 18:69-71.
11. Cebrian JL, Morán MA, Gomez-Ramos P. 1997. Association of cholinesterases with amyloid in extracellular neurofibrillary tangles. Brain Res 769:173-177.
12. Corder EH, Saunders AM, Strittmatter WJ, Schmechhhel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA. 1993. Gene dose of Apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261:921-923.
13. Danik M, Poirier J. 1998. Apolipoprotein E and neuronal plasticity following experimental de-afferentation and Alzheimer's disease Biochem Soc Trans 26:262-266.
14. Dickson TC, Saunders HL, Vickers JC. 1997. Relationship between Apoliprotein E and the amyloid deposits and dystrophic neurites of Alzheimer's disease. Neuropathol Appl Neurobiol 23:483-491.
15. Einstein G, Patel V, Bautista P, Kenna M, Melone L, Fader R, Karson K, Mann S, Saunders MI, Hulette C, Mash D, Roses AD, Schmechel DE. 1998. Intraneuronal ApoE in human visual cortical areas reflects the staging of Alzheimer disease pathology. J Neuropathol Exp Neurol 57:1190-1201.
16. Gómez-Ramos P, Morán MA. 1998. Ultrastructural aspects of neurofibrillary tangle formation in aging and Alzheimer's disease. Microsc Res Tech 43:49-58.
17. Hall ED, Oostveen JA, Dunn E, Carter DB. 1995. Increased amyloid protein precursor and apolipoprotein E immunoreactivity in the selectively vulnerable hippocampus following transient forebrain ischemia in gerbils. Exp Neurol 135:17-27.
18. Han SH, Hulette C, Saunders AM, Einstein G, Pericak-Vance M, Strittmatter WJ, Roses AD, Schmechel DE. 1994a. Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls. Exp Neurol 128:13-26.
19. Han SH, Einstein G, Weisgraber KH, Strittmatter WJ, Saunders AM, Pericak-Vance M, Roses AD, Schmechel DE. 1994b. Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study. J Neuropathol Exp Neurol 53:535-544.
20. Horsburgh K, Graham DI, Stewart J, Nicoll JAR. 1999. Influence of Apolipoprotein E genotype on neuronal damage and apoE immunoreactivity in human hippocampus following global ischemia. J Neuropathol Exp Neurol 58:227-234.
21. Kosik KS, Joachim CL, Selkoe DJ. 1986. Microtubule-associated protein tau is a major antigenic component of paired helical filaments in Alzheimer disease. Proc Natl Acad. Sci. USA 83:4044-4048.
22. Laws SM, Taddei K, Martins G, Paton A, Fiser C, Clarnette R, Hallmayer J, Brooks WS, Gandy SE, Martins RN. 1999. The -491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease. NeuroReport 10:879-882
23. Mercken L, Brion JP. 1995. Phosphorylation of tau protein is not affected in mice lacking apoliprotein E. NeuroReport 6:2381-2384.
24. Mercken M, Vandermeeren M, Lübke U, Six J, Boons J, Van de Voorde A, Martin JJ, Gheuens J. 1992. Monoclonal antibodies with selective specificity for Alzheimer tau are directed against phosphatase-sensitive epitopes. Acta Neuropathol (Berl) 84:265-272
25. Metzger RE, LaDu ML, Pan JB, Getz GS, Frail DE, Falduto MT. 1996. Neurons of the human frontal cortex display apolipoprotein E immunoreactivity: Implications for Alzheimer's disease. J Neuropathol Exp Neurol 55:372-380.
26. Mirra SS, Hyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L, participating CERAD neuropathologists. 1991. The consortium to establish a registry for Alzheimer's disease (CERAD). Part II Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41:479-486.
27. Mukaetova-Ladinska EB, Harrington CR, Roth M, Wischik CM. 1997. Presence of the apolipoprotein E type e4 allele is not associated with neurofibrillary pathology or biochemical changes to tau protein. Dement Geriatr Cogn Disord 8:288-295.
28. Nagy ZS, Esiri MM, Jobst KA, Johnston C, Litchfield S, Sim E, Smith AD. 1995. Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease. Neuroscience 69:757-761.
29. Namba Y, Tomonaga M, Kawasaki H, Otomo E, Ikeda K. 1991. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jacob disease. Brain Res 541:163-166.
30. Ohm TG, Kirca M, Bohl J, Scharnagl J, Grob W. März W. 1995. Apolipoprotein E polymorphism influences not only cerebral senile plaque load but also Alzheimer-type neurofibrillary tangle formation. Neuroscience 66:583-587.
31. Perry G, Cras P, Kawai M, Mulvihill P, Tabaton M. 1991. Transformation of neurofibrillary tangles in the extracellular space. Bull Clin Neurosci 56:107-119.
32. Poirier J. 1994. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neurosci 17:525-530.
33. Poirier J, Hess M, May PC, Finch CE. 1991. Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after enthorinal cortex lesioning. Mol Brain Res 11:97-106.
34. Richey L, Siedlak SL, Smith MA, Perry G. 1995. Apolipoprotein E interaction with the neurofibrillary tangles and senile plaques in Alzheimer disease: implications for disease pathogenesis. Biochem Biophys Res Commun 208:657-663.
35. Saunders AM, Strittmatter WJ, Schmechel D, St George-Hyslop PH, Pericak-Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Alberts MJ, Hulette C, Crain B, Goldgaber D, Roses AD. 1993. Association of apolipoprotein E allele e4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43: 1467-1472.
36. Snow AD, Mar H, Nochlin D, Sekiguchi RT, Kimata K, Koike Y, Wight TN. 1990. Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein-containing lesions of Alzheimer's disease and Down's syndrome. Am J Pathol 137:1253-1270.
37. Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvensen GS, Roses AD. 1993. Apolipoprotein E high-avidity binding to β amyloid and increase frequency of type 4 allele in late-onset familial Alzheimer's disease. Proc Natl Acad Sci 90: 1977-1981.
38. Strittmatter WJ, Weisgraber KH, Goedert RI, Saunders AM, Huang D, Corder EH, Dong L-M, Jakes R, Alberts MJ, Gilbert JR, Han S-H, Hulette C, Einstein G, Schmechel DE, Pericak-Vance MA, Roses AD. 1994. Hypothesis: microtubules inestability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. Exp Neurol 125:163-171.
39. Wang XS, Luebbe P, Gruenstein E, Zemlan F. 1998. Apolipoprotein E (ApoE) peptide regulates tau phosphorylation via two different signaling pathways. J Neurosci Res 51:658-665.
40. Xu PT, Gilbert JR, Qiu HL, Rothrock-Christian T, Settles DL, Roses AD, Schhmechel DE. 1998. Regionally specific neuronal expression of human APOE gene in transgenic mice. Neurosci Lett 246:65-68.
41. Xu PT, Gilbert JR, Qiu HL, Ervin J, Rothrock-Christian TR, Hulette C, Schmechel DE. 1999. Specific regional transcription of Apolipoprotein E in human brain neurons. Am J Pathol 154:601-611.
42. Yamaguchi H, Ishiguro K, Sugihara S, Nakazato Y, Kawarabayashi T, Sun X, Hirai S. 1994. Presence of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the Alzheimer β amyloid deposition. Acta Neuropathol 88: 413-419.