Pulmonary CYP1A1 and CYP1A2 levels and activities in adult male and female offspring of rats exposed during gestation and lactation to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Biochemical Pharmacology

Volumn 62, Issue 5, 2001, Pages 617-626

  Iba, Michael M ^a   Fung, Jacqueline ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

2 Induction; CYP1A1; EROD activity; Gestational TCDD exposure; Lung microsomes; MeIQ bioactivation

Indexed keywords

2 AMINO 3,4 DIMETHYLIMIDAZO[4,5 F]QUINOLINE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; ETHOXYRESORUFIN DEETHYLASE;

AMES TEST; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EXPOSURE; ENZYME ACTIVITY; FEMALE; LUNG; MALE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROGENY; PROTEIN INDUCTION; RAT; SEX DIFFERENCE;

ANIMALS; BIOTRANSFORMATION; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; FEMALE; GESTATIONAL AGE; LACTATION; LUNG; MALE; MICROSOMES; PREGNANCY; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TERATOGENS; TETRACHLORODIBENZODIOXIN;

EID: 0035452137     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00721-3     Document Type: Article

References (62)

1. The Ah receptor: Mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds
2. 1-450 (CYP1A1) gene
3. The Ah locus: Genetic differences in toxicity, cancer, mutation, and birth defects
4. Proposed role of drug-metabolizing enzymes: Regulation of steady state levels of the ligands that affect growth homeostasis, differentiation and neuroendocrine functions
5. Endocrine effects of prenatal exposure to PCB, dioxins, and other xenobiotics: Implications for policy and future research
6. A critical review of the developmental toxicity and teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: Recent advances toward understanding the mechanism
7. Developmental and reproductive toxicity of dioxins and related compounds: Cross-species comparisons
8. Contribution of human cytochrome P450 to benzo[a]pyrene-7,8-dihydrodiol metabolism, as predicted from heterologous expression in yeast
9. The role of 12 cDNA-expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans-7,8-dihydrodiol
10. Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens
11. Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450
12. DNA adducts and chronic degenerative diseases. Pathogenetic relevance and implications in preventive medicine
13. Proliferative responses of quail aortic smooth muscle cells to benzo[a]pyrene: Implications in PAH-induced atherogenesis
14. The aryl hydrocarbon receptor complex
15. ISF/BNF-G
16. 3450 genes: Differential transcriptional activation and mRNA stability in liver and extrahepatic tissues
17. Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice
18. Phenobarbital induces cytochrome P4501A2 hnRNA, mRNA and protein in the liver of C57BL/6J wild type and aryl hydrocarbon receptor knock-out mice
19. Differential induction of two 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible forms of cytochrome P-450 in extrahepatic versus hepatic tissues
20. The molecular biology of cytochrome P450s
21. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin and phenobarbital on the occurrence and distribution of four cytochrome P-450 isozymes in rabbit kidney, lung, and liver
22. Differential induction of fetal mouse liver and lung cytochromes P-450 by β-naphthoflavone and 3-methylcholanthrene
23. Tissue- and cell type-specific expression of cytochrome P450 1A1 and cytochrome P450 1A2 mRNA in the mouse localized in situ hybridization
24. CYP1A1 and CYP1B1, two hydrocarbon-inducible cytochromes P450, are constitutively expressed in neonate and adult goat liver, lung and kidney
25. Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002
26. A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6
27. Effect of gestational and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on the level and catalytic activities of hepatic microsomal CYP1A in prepubertal and adult rats
28. Transplacental induction of carcinogen-hydroxylating systems with 2,3,7,8-tetrachlorodibenzo-p-dioxin
29. Postnatal stimulation of hepatic microsomal enzymes following administration of TCDD
30. Heme oxygenase-1 mRNA levels, metallothionein mRNA levels, lipid peroxidation, and microsomal CYP1A activities in rats treated with 3,3′-dichlorobenzidine and some other inducers of P450
31. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
32. Synergistic induction of CYP1A1 and CYP1A2 by acetone in combination with pyridine
33. Cytochrome P-450-dependent biotransformation of a series of phenoxazone ethers in the rat conceptus during early organogenesis: Evidence of multiple P-450 isoenzymes
34. Purification and characterization of liver microsomal cytochromes P-450: Electrophoretic, spectral, catalytic and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or β-naphthoflavone
35. A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal cellular fractions
36. Activation of 3,3′-dichlorobenzidine in rat liver microsomes to mutagens: Involvement of cytochrome P-450d
37. Revised methods for the Salmonella test
38. Coordinate up-regulation of CYP1A1 and heme oxygenase (HO-1) expression and modulation of δ-aminolevulinic acid synthase and tryptophan pyrrolase activities in pyridine-treated rats
39. Characterization of nine monoclonal antibodies against rat hepatic cytochrome P450c. Delineation of at least five spatially distinct epitopes
40. 3-Methylcholanthrene and pyridine effects on CYP1A1 and CYP1A2 expression in rat renal tissue
41. Detection of CYP1A1 mRNA levels and CYP1A1 Msp polymorphisms as possible biomarkers of exposure and susceptibility in smokers and non-smokers
42. Protein measurement with the folin phenol reagent
43. Toxicokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats including placental and lactational transfer to fetuses and neonates
44. Subcellular localization of TCDD differs between the liver, lungs, and kidneys after acute and subchronic exposure: Species/dose comparisons and possible mechanism
45. Lipid peroxidation and the degradation of cytochrome P-450 heme
46. NADPH- and linoleic acid hydroperoxide-induced lipid peroxidation and destruction of cytochrome P-450 in hepatic microsomes
47. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced lipid peroxidation in hepatic and extrahepatic tissues of male and female rats
48. Dioxin causes a sustained oxidative stress response in the mouse
49. Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver
50. Delayed ontogenesis of CYP1A2 in the human liver
51. Developmental regulation of cytochrome P450 genes in the rat
52. Identification and functional characterization of a conserved nuclear factor 1-like element in the proximal promoter region of CYP1A2 gene specifically expressed in the liver and olfactory mucosa
53. Constitutive and induced expression by pyridine and β-naphthoflavone of rat CYP1A is sexually dimorphic
54. Induction of pulmonary CYP1A1 by nicotine
55. Hepatocarcinogenic heterocyclic amines that induce P-448 isozymes, mainly cytochrome P-448H (P-450IA2), responsible for mutagenic activation of the carcinogens in the rat liver
56. Effects of the food mutagens MeIQx and PhIP on the expression of cytochrome P450IA proteins in various tissues of male and female rats
57. TCDD-induced changes in rat liver microsomal enzymes
58. Human cytochromes P450: Problems and prospects
59. Role of cytochrome P450 1A2 in chemical carcinogenesis: Implications for human variability in expression and enzyme activity
60. Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes
61. Characterization of xenobiotic-metabolizing enzyme expression in human bronchial mucosa and peripheral lung tissues
62. Characterization of cytochrome P450 expression in human esophageal mucosa